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Application of miRNA-214 as biomarker in parkinson's disease prodriving period

A miRNA-214, 1. mirna-214 technology is applied in the application field of miRNA-214 as a biomarker of the prodromal stage of Parkinson's disease, to achieve the effects of assisting the prodromal stage of PD, ensuring life safety, and assisting diagnosis

Active Publication Date: 2021-06-25
NANJING BRAIN HOSPITAL
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Problems solved by technology

Then this period is a very critical period for diagnosis; the common non-motor symptoms of patients include depression, constipation, olfactory disturbance, etc., but it is impossible to accurately judge whether they will develop into PD patients only through these non-motor symptoms. Markers are a very effective means. In the prior art, there are no relevant biomarkers for PD prodromal diagnosis

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  • Application of miRNA-214 as biomarker in parkinson's disease prodriving period
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  • Application of miRNA-214 as biomarker in parkinson's disease prodriving period

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Embodiment Construction

[0010] In order to express the present invention more clearly, the present invention will be further described below in conjunction with the accompanying drawings.

[0011] In the following description, general example details are given in order to provide a deeper understanding of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. It should be understood that the specific examples are only used to explain the present invention, not to limit the present invention.

[0012] It should be understood that when the terms "comprises" and / or "comprises" are used in this specification, they indicate the presence of said features, integers, steps, operations, elements or components, but do not exclude the presence or addition of one or more other features, integers, steps, operations, elements, assemblies or combinations thereof.

[0013] With the upsurge of microRNA (microRNA, miRNA) research, this...

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Abstract

The invention provides an application of miRNA-214 as a biomarker of a Parkinson's disease in a prophase period. By rapidly measuring the content of miRNA-214 in venous blood of middle-aged and elderly people, the kit is used for screening and predicting the risk of the PD proactive period, supervising and urging a patient to see a doctor in time, delaying disease progression and guaranteeing life safety of the patient. Researches find that the expression quantity of the miRNA-214 provided by the invention in venous blood of a patient in the PD proactive period is obviously higher than that of a normal person, and the aim of auxiliary diagnosis of the PD proactive period can be achieved by specifically monitoring the miRNA-214.

Description

technical field [0001] The invention relates to the technical field of biological detection, in particular to the application of miRNA-214 as a biomarker in the prodromal stage of Parkinson's disease. Background technique [0002] Parkinson's disease (PD) is a common neurodegenerative disease, clinically manifested as bradykinesia, resting tremor, muscle rigidity, abnormal gait and posture, hyposmia, depression and other symptoms, its etiology and mechanism So far unknown. About 1% of people over the age of 65 have PD. The main pathological features are the selective and progressive degeneration of dopamine (DA) neurons in the substantia nigra compacta of the midbrain, a significant decrease in the content of DA in the striatum, and eosinophilic inclusion bodies in the residual neurons - Lewy bodies, mainly composed of Alpha-synuclein (α-syn) composition. After decades of research, the diagnosis and treatment of PD are still not ideal; at present, the clinical diagnosis o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/178C12Q2600/158
Inventor 刘卫国于翠玉闫磊李蓝婷
Owner NANJING BRAIN HOSPITAL
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