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Application of 5-pyridoxolactone in the preparation of medicines for inhibiting silkworm nuclear polyhedrosis virus

A nuclear polyhedron and silkworm technology, applied in the field of biomedicine, to achieve good safety results

Active Publication Date: 2022-06-03
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

At present, there is no effective drug report for the silkworm disease caused by the virus infection. Therefore, there is an urgent need for a method that can quickly and efficiently inhibit the infection of the silkworm baculovirus (BmNPV), so as to provide information on the silkworm karyotype for the research on the mechanism of silkworm resistance to BmNPV virus and the silkworm production. Laying the foundation for the prevention and treatment of polyhedrosis virus disease

Method used

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  • Application of 5-pyridoxolactone in the preparation of medicines for inhibiting silkworm nuclear polyhedrosis virus
  • Application of 5-pyridoxolactone in the preparation of medicines for inhibiting silkworm nuclear polyhedrosis virus
  • Application of 5-pyridoxolactone in the preparation of medicines for inhibiting silkworm nuclear polyhedrosis virus

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Embodiment 1

[0034] The present embodiment obtains the same detection results as in Example 1.

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Abstract

The invention discloses the application of 5-Pyridoxolactone in the preparation of medicines for inhibiting the nuclear polyhedrosis virus of silkworm, by rationally utilizing the small molecule 5-Pyridoxolactone in the host cell of the anti-BmNPV virus to inhibit its replication in the cell, that is, when the cell is infected After BmNPV virus infection, adding 5‑Pyridoxolactone first inhibits the replication of BmNPV virus, which provides a new idea for the treatment of BmNPV infection in cells, and also lays a foundation for the prevention and treatment of virus infection in sericulture production.

Description

5‑Pyridoxolactone for preparing medicine for inhibiting silkworm nuclear polyhedrosis virus applications in technical field The present invention relates to the field of biomedicine, be specifically related to 5-Pyridoxolactone is used to prepare suppress silkworm karyotype Drug application of polyhedrosis virus. Background technique Bombyx mori nuclear polyhedrosis virus (BmNPV) belongs to the baculovirus that mainly infects invertebrates, especially insects division. Bombyx mori disease caused by BmNPV infection is one of the most harmful, difficult to control, and there is no effective control measures. Silkworm disease. BmNPV virus baculovirus is mainly divided into nuclear polyhedrosis virus and particle virus by inclusion body type. BmNPV disease The virulent genome is 128 kb in size and contains 136 genes. BmNPV virus produces two different types of viruses in two developmental stages, one is inclusion body derived disease virus (ODV) and budding viru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4355A61P31/20
CPCA61K31/4355A61P31/20Y02A50/30
Inventor 夏庆友化晓婷
Owner SOUTHWEST UNIV
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