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Traditional Chinese medicine extract for treating breast cancer as well as preparation method and application of traditional Chinese medicine extract

A technology of extracts and traditional Chinese medicines, which is applied in the field of traditional Chinese medicine extracts and their preparations for the treatment of breast cancer, can solve the problems of general inhibition of breast cancer cell proliferation and high cost, and achieve good proliferation inhibition, small side effects, and good synergy Effect

Active Publication Date: 2021-07-20
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in the prior art, the effect of inhibiting the proliferation of breast cancer cells is general, and the effect of treating breast cancer needs to be improved urgently. In addition, due to the large number of traditional Chinese medicine components, the cost is high, and it has certain side effects.

Method used

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  • Traditional Chinese medicine extract for treating breast cancer as well as preparation method and application of traditional Chinese medicine extract
  • Traditional Chinese medicine extract for treating breast cancer as well as preparation method and application of traditional Chinese medicine extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A traditional Chinese medicine extract. According to the ratio of parts by weight, the raw materials include: 10 parts of Pulsatilla chinensis, 20 parts of Scutellaria baicalensis, 10 parts of Cortex Phellodendri, 5 parts of Eupatorium, 5 parts of Dandelion, 10 parts of Yangjinhua and 12 parts of Viola chinensis.

[0038] The preparation method of described Chinese medicine extract comprises the following steps:

[0039] (1) Grind Pulsatilla radix, Scutellaria baicalensis and Cortex Phellodendri to 70 mesh, add 5 times the mass of ethanol to mix at 50°C, add 3% mass of sorbic acid for extraction; filter to obtain mixed extract 1 and residue 1;

[0040] (2) Take dandelion, eupatorium, datura and viola, add 4 times volume concentration to 60% ethanol aqueous solution, add residue 1 to extract, filter, and make mixed extract 2 and residue 2;

[0041] (3) Mix residue 1 and residue 2, add water, add 1.0% sodium citrate, follow the gradient of 30°C, 45°C, 60°C, 70°C, 80°C, 10...

Embodiment 2

[0044] A traditional Chinese medicine extract. According to the ratio of parts by weight, the raw materials include: 5 parts of Pulsatilla chinensis, 10 parts of Scutellaria baicalensis, 5 parts of Cortex Phellodendri, 1 part of Eupatorium chinensis, 1 part of Dandelion, 5 parts of Yangjinhua and 5 parts of Viola chinensis.

[0045] The preparation method of described Chinese medicine extract comprises the following steps:

[0046] (1) Take Pulsatilla radix, Scutellaria baicalensis and Cortex Phellodendri to crush to 60 mesh, add 6 times the mass of ethanol to mix at 40°C, add 5% mass of sorbic acid for extraction; filter to obtain mixed extract 1 and residue 1;

[0047] (2) Take dandelion, eupatorium, datura and viola, add 3 times volume concentration to 50% ethanol aqueous solution, add residue 1 to extract, filter, and make mixed extract 2 and residue 2;

[0048] (3) Mix residue 1 and residue 2, add water, add 0.5% sodium citrate, follow the gradient of 30°C, 45°C, 60°C, 70...

Embodiment 3

[0051] A traditional Chinese medicine extract. According to the ratio of parts by weight, the raw materials include: 20 parts of Pulsatilla chinensis, 30 parts of Scutellaria baicalensis, 15 parts of Cortex Phellodendri, 10 parts of Eupatorium chinensis, 10 parts of Dandelion, 15 parts of Yangjinhua and 20 parts of Viola chinensis.

[0052] The preparation method of described Chinese medicine extract comprises the following steps:

[0053](1) Take Pulsatilla radix, Scutellaria baicalensis and Cortex Phellodendri to crush to 80 mesh, add 3 times the mass of ethanol to mix at 60°C, add 0.5% mass of sorbic acid for extraction; filter to obtain mixed extract 1 and residue 1;

[0054] (2) Mix dandelion, eupatorium, datura and viola, add 6 times volume concentration to 75% ethanol aqueous solution, add residue 1 to extract, filter to obtain mixed extract 2 and residue 2;

[0055] (3) Mix residue 1 and residue 2, add water, add 1.5% sodium citrate, follow the gradient of 30°C, 45°C, ...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine extract for treating breast cancer and a preparation method and application of the traditional Chinese medicine extract. The traditional Chinese medicine extract is prepared from the following raw materials: Pulsatillae Radix, radix scutellariae, cortex phellodendri, herba lycopi, dandelion, flos daturae and herba violae. The traditional Chinese medicine extract has a good proliferation inhibition effect on breast cancer cells and small side effect. When the breast cancer is treated, the drug response of a patient can be reduced.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine extract for treating breast cancer, a preparation method and application thereof. Background technique [0002] Breast cancer is a phenomenon in which breast epithelial cells proliferate uncontrollably under the action of various carcinogenic factors. In the early stage of the disease, symptoms such as breast lumps, nipple discharge, and axillary lymph node enlargement are often manifested. In the late stage, cancer cells may metastasize to distant places and cause multiple organ lesions, which directly threaten the lives of patients. [0003] Chemotherapy drugs for the treatment of breast cancer generally interfere with the reproduction of cancer cells by changing or inhibiting the biochemical metabolic process of cancer cells, mainly anthracyclines and paclitaxel. Anthracyclines: Common drugs include ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61K47/12A61P35/00
CPCA61K36/71A61K36/539A61K36/756A61K36/53A61K36/288A61K36/81A61K36/86A61K47/12A61P35/00A61K2236/15A61K2236/33A61K2236/333A61K2236/331A61K2300/00
Inventor 肖军平陈梁李小锋毛金娣周朝忠夏淑英
Owner JIANGXI POZIN PHARMA
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