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A kind of traditional Chinese medicine extract for treating breast cancer and its preparation method and application

An extract and a breast cancer technology are applied in the field of traditional Chinese medicine extracts for the treatment of breast cancer and the preparation thereof, which can solve the problems of high cost and general inhibitory effect on breast cancer cell proliferation, and achieve low side effects, good proliferation inhibitory effect, and good synergy. effect of action

Active Publication Date: 2022-05-27
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, in the prior art, the effect of inhibiting the proliferation of breast cancer cells is general, and the effect of treating breast cancer needs to be improved urgently. In addition, due to the large number of traditional Chinese medicine components, the cost is high, and it has certain side effects.

Method used

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  • A kind of traditional Chinese medicine extract for treating breast cancer and its preparation method and application
  • A kind of traditional Chinese medicine extract for treating breast cancer and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A traditional Chinese medicine extract, according to the ratio of parts by weight, the raw materials include: 10 parts of Pulsatilla, 20 parts of Scutellaria baicalensis, 10 parts of Treats, 5 parts of Zelan, 5 parts of dandelion, 10 parts of Panax japonica and 12 parts of Viola.

[0038] The preparation method of the Chinese medicine extract comprises the following steps:

[0039] (1) get Pulsatilla scutellariae, Scutellaria baicalensis, Phellodendron phellodendri and pulverize to 70 meshes, add 5 times the mass of ethanol and mix at 50 ° C, add 3% mass of sorbic acid to extract; filter to obtain mixed extract 1 and residue 1;

[0040] (2) get dandelion, zelan, japonica and violacea and mix, add 4 times of 60% ethanol aqueous solution by volume, then add residue 1 to extract, filter to obtain mixed extract 2 and residue 2;

[0041] (3) Mix Residue 1 and Residue 2, add water, add 1.0% sodium citrate, and carry out a gradient of 30°C, 45°C, 60°C, 70°C, 80°C, and 100°C, w...

Embodiment 2

[0044] A traditional Chinese medicine extract, according to the ratio of parts by weight, the raw materials include: 5 parts of Pulsatilla, 10 parts of Scutellaria baicalensis, 5 parts of Cork Phellodendri, 1 part of Zelan, 1 part of Dandelion, 5 parts of Panax japonica and 5 parts of Radix Paeoniae Alba.

[0045] The preparation method of the Chinese medicine extract comprises the following steps:

[0046] (1) get Pulsatilla scutellariae, Scutellaria baicalensis, and Phellodendron phellodendri and pulverize to 60 meshes, add 6 times the mass of ethanol and mix at 40 ° C, add 5% mass of sorbic acid to extract; filter to obtain mixed extract 1 and residue 1;

[0047] (2) get dandelion, zelan, galanga japonica and violacea and mix, add 3 times the volume concentration of 50% ethanol aqueous solution, then add residue 1 to extract, filter to obtain mixed extract 2 and residue 2;

[0048] (3) Mix Residue 1 and Residue 2, add water, add 0.5% sodium citrate, and proceed according to...

Embodiment 3

[0051] A traditional Chinese medicine extract, according to the ratio of parts by weight, the raw materials include: 20 parts of Pulsatilla, 30 parts of Scutellaria baicalensis, 15 parts of Phellodendron chinensis, 10 parts of Zelan, 10 parts of dandelion, 15 parts of Panax japonica, and 20 parts of Viola.

[0052] The preparation method of the Chinese medicine extract comprises the following steps:

[0053](1) take Pulsatilla scutellariae, Scutellaria baicalensis, Phellodendron phellodendri and pulverize to 80 mesh, add 3 times the mass of ethanol and mix at 60 ° C, add 0.5% mass of sorbic acid to extract; filter to obtain mixed extract 1 and residue 1;

[0054] (2) get dandelion, zelan, japonica and violacea and mix, add 6 times the volume concentration of 75% ethanol aqueous solution, then add residue 1 to extract, filter to obtain mixed extract 2 and residue 2;

[0055] (3) Mix Residue 1 and Residue 2, add water, add 1.5% sodium citrate, and carry out a gradient of 30°C, 4...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine extract for treating breast cancer, a preparation method and application thereof. The traditional Chinese medicine extract, the preparation raw materials include: Pulsatilla, Scutellaria, Phellodendron, Eupatorium, Dandelion, Yangjinhua and Zihuadiding. The extracts of traditional Chinese medicine have a good inhibitory effect on the proliferation of breast cancer cells. The side effect is small, and the drug reaction of patients can be reduced while treating breast cancer.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine extract for treating breast cancer and a preparation method and application thereof. Background technique [0002] Breast cancer is a phenomenon in which mammary epithelial cells proliferate out of control under the action of various carcinogenic factors. In the early stage of the disease, symptoms such as breast lumps, nipple discharge, and axillary lymph node enlargement are often manifested. In the late stage, cancer cells may metastasize far away, resulting in multi-organ lesions, which directly threaten the patient's life. [0003] Chemotherapy drugs for breast cancer generally interfere with the reproduction of cancer cells by changing or inhibiting the biochemical metabolic process of cancer cells, mainly anthracyclines and paclitaxel. Anthracyclines: Common drugs include doxorubicin, epirubicin,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/86A61K47/12A61P35/00
CPCA61K36/71A61K36/539A61K36/756A61K36/53A61K36/288A61K36/81A61K36/86A61K47/12A61P35/00A61K2236/15A61K2236/33A61K2236/333A61K2236/331A61K2300/00
Inventor 肖军平陈梁李小锋毛金娣周朝忠夏淑英
Owner JIANGXI POZIN PHARMA
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