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Large-area-array liquid drop detection optical system

An optical system and large area array technology, applied in the field of digital PCR, to achieve the effect of reasonable design, convenient use, and smooth illumination

Pending Publication Date: 2021-07-23
SHENZHEN BIORAIN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the optical module is used to image the droplets in the chip. At present, the field of droplet digital PCR instrument is mainly divided into two categories: flow type and imaging type. The structure is ever-changing, which brings new challenges to the optical imaging module

Method used

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  • Large-area-array liquid drop detection optical system
  • Large-area-array liquid drop detection optical system
  • Large-area-array liquid drop detection optical system

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Embodiment Construction

[0049] The invention will be described in detail below with reference to the accompanying drawings and specific embodiments.

[0050] Refer Figure 1 to 8 As shown, the present invention provides a largermost array droplet detecting optical system, including a lighting mechanism 1 disposed at a chip 7 to be detected, a light source switching mechanism 2 disposed above the chip 7, and is located above the light source switching mechanism 2. Imaging mechanism 3; the light source switching mechanism 2 is also attached to the spectroscope module 4 and the excitation light module 5, and the light emitted by the lighting mechanism 1 is used to illuminate the imaging area 71 on the chip 7 and sequentially transmitted through the chip 7. The spectroscope module 4 enters the imaging mechanism 3 to imaging the microfluidic droplets on the chip 7; the light emitted by the excitation light module 5 is used to reflect the excitation area that is reflected on the chip 7 via the spectroscope modu...

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Abstract

The invention discloses a large-area-array liquid drop detection optical system which comprises an illumination mechanism arranged below a chip to be detected, a light source switching mechanism arranged above the chip to be detected and an imaging mechanism located above the light source switching mechanism. The light source switching mechanism is further provided with a spectroscope module and an exciting light module, and light emitted by the illumination mechanism is used for irradiating an imaging area on the chip and sequentially penetrates through the chip and the spectroscope module to enter the imaging mechanism so as to image micro-droplets on the chip. The system is reasonable in design, compact in structure and convenient to use, and can be used for imaging liquid drops which are amplified and irradiated by exciting light, so that relevant concentration data are obtained, and a guarantee is provided for accurate quantitative analysis of a sample.

Description

Technical field [0001] The present invention relates to the field of digital PCR, and in particular, to a large-scale array droplet detection optical system. Background technique [0002] The digital PCR instrument is an application to prevent medical research instruments in the field of medicine and public health, which is mainly to provide precision quantitative analysis of samples. The digital PCR instrument generally includes the following modules: chip delivery module, droplet generation module, amplification module, detection module, optical module, computer control module, etc. Among them, the optical module is imaged on the droplets in the chip. At present, the microphone digital PCR field is mainly divided into two categories of streaming and imaging, and due to different chip structures, the digital PCR instrument is actually actually The structure has become a new challenge to the optical imaging module. Inventive content [0003] It is an object of the present invent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64G01N21/01C12M1/34C12Q1/686
CPCC12Q1/686G01N21/01G01N21/6428G01N21/645G01N21/6456G01N2021/0112G01N2021/6471G01N2021/6478C12Q2563/159
Inventor 陈凤东阳巍董冰
Owner SHENZHEN BIORAIN BIOTECHNOLOGY CO LTD