Adjustable conjoined symbiotic mouse tail intravenous injection double-cylinder fixing device and use method

Abstract

The invention relates to an adjustable conjoined symbiotic mouse tail intravenous injection double-cylinder fixing device and a use method. The device comprises the following components: a base; fixed double cylinders, which are arranged on the base and comprise a first fixed cylinder and a second fixed cylinder which are fixed together in parallel, and first through holes which extend in the axial direction of the first fixed cylinder and the second fixed cylinder and penetrate through the cylinder walls of the first fixed cylinder and the second fixed cylinder are formed in the first fixed cylinder and the second fixed cylinder, wherein a second through hole which extends in the axial direction of the first fixing cylinder and the second fixing cylinder and penetrates through the cylinder walls is formed in the fixed connecting part of the first fixing cylinder and the second fixing cylinder, a plurality of third through holes which are distributed at intervals in the axial direction of the first fixing cylinder and the second fixing cylinder and extend in the circumferential direction are formed in the first fixing cylinder and the second fixing cylinder; a head ventilation baffle, which is detachably mounted in the third through hole; and a tail baffle plate, which is arranged on the fixed double cylinder and is positioned at one end far away from the third through hole. The device is convenient, effective in fixation, accurate in injection and capable of relieving the pain of the conjoined symbiotic mouse.

Description

technical field [0001] The invention relates to an adjustable conjoined symbiotic rat tail vein injection double-barrel fixing device and a using method, and belongs to the field of animal medical experimental instruments. Background technique [0002] Conjoined symbiosis is a modeling method in medical experiments, which refers to the longitudinal incision of the lateral skin of two animals by experimental means, and the incisions are sutured to form a conjoined body. After conjoining, they share a set of blood circulatory system to form the interaction of body fluids and blood to achieve symbiosis. At present, parabiosis animal models have been applied in tumors, endocrinology, transplantation, neurology, and stomatology. For parabiosis animals, mice are often used as model animals. Among them, the United States, the United Kingdom, Switzerland and Japan have more researches on the application of parabiosis animal models, and my country has rarely applied this experimenta...

AI Technical Summary

Problems solved by technology

First of all, because the tail vein of the mouse is thin, it is extremely difficult to insert the needle, and it is not easy to distinguish with the naked eye. It is even more difficult to operate if the mice are conjoined; The injection operation is more difficult; finally, because the rat tail vein injection fixation devices currently on the market are all single-barreled, the research on the tail vein injection double-barrel fixation device for parabiotic mice is still blank

There are still many disadvantages in the existing mouse single-tube tail vein injection fixation device. First, it cannot adjust the size of the fixer according to the size of the mouse, and there are often cases of insufficient fixation or too tight fixation

If it is not fixed stably, the body of the mouse will turn over and the tail will swing during the injection process, resulting in the inability to complete the injection operation or causing multiple wounds on the tail of the mouse, and even stabbing the operator's fingers

Secondly, the traditional injection method is difficult for colored mice (black or brown-black) to identify the position of the tail vein blood vessel, and the injection is difficult, which affects the injection efficiency. In addition, when the tail vein of the mouse is not filled enough, the operator cannot accurately observe whether the needle enters the blood vessel. , injection accuracy is low

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