Application of hippophae rhamnoides polysaccharide in preparing of preparation for preventing and/or treating porcine pseudorabies virus infection

A technique for porcine pseudorabies and seabuckthorn polysaccharides, which is applied in the field of application of seabuckthorn polysaccharides in the preparation of preparations for preventing and/or treating porcine pseudorabies virus infection, can solve the problems that the virus inhibitory effect has not been reported, and achieve the preparation of small pollution and safety High, reduce the effect of cell disease

Active Publication Date: 2021-07-27
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inhibitory effect of Hippophae rhamnoides polysaccharide (HRP) on viruses has not been reported

Method used

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  • Application of hippophae rhamnoides polysaccharide in preparing of preparation for preventing and/or treating porcine pseudorabies virus infection
  • Application of hippophae rhamnoides polysaccharide in preparing of preparation for preventing and/or treating porcine pseudorabies virus infection
  • Application of hippophae rhamnoides polysaccharide in preparing of preparation for preventing and/or treating porcine pseudorabies virus infection

Examples

Experimental program
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Effect test

Embodiment 1

[0043] A preparation for preventing and / or treating porcine pseudorabies virus infection. Seabuckthorn polysaccharide (Ciyuan Biotechnology Co., Ltd.) is dissolved in PBS buffer solution, and the concentration of seabuckthorn polysaccharide is 250 μg / mL.

Embodiment 2

[0045] A preparation for preventing and / or treating porcine pseudorabies virus infection. The seabuckthorn polysaccharide is dissolved in PBS buffer solution, and the concentration of the seabuckthorn polysaccharide is 500 μg / mL.

Embodiment 3

[0047] A preparation for preventing and / or treating porcine pseudorabies virus infection, comprising dissolving seabuckthorn polysaccharide in PBS buffer, and the concentration of seabuckthorn polysaccharide is 750 μg / mL.

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Abstract

The invention discloses application of hippophae rhamnoides polysaccharide in preparing of a preparation for preventing and / or treating porcine pseudorabies virus infection. In-vitro cell experiments prove that the hippophae rhamnoides polysaccharide can effectively inhibit porcine pseudorabies virus infection and can significantly reduce cytopathy caused by porcine pseudorabies virus. The hippophae rhamnoides polysaccharide is added in different stages of virus infection, and the hippophae rhamnoides polysaccharide is found to mainly inhibit adsorption, endocytosis and replication of viruses to cells. The invention provides a safe and effective preparation with low toxic and side effects for clinically preventing and / or treating porcine pseudorabies virus infection.

Description

technical field [0001] The invention belongs to the field of antiviral applications, and in particular relates to the application of seabuckthorn polysaccharides in the preparation of preparations for preventing and / or treating porcine pseudorabies virus infection. Background technique [0002] Pseudorabies (PR), also known as Aujeszky's disease (AD), is an acute and severe infectious disease caused by pseudorabies virus (PRV), mainly causing a variety of livestock and wild animals Symptoms such as fever, itching, and encephalomyelitis. PRV is a double-stranded DNA virus belonging to the subfamily A and Herpesviridae. Although PRV can infect a variety of mammals, such as dogs, cats, cattle, sheep, and rabbits, pigs are the only natural host. Porcine pseudorabies is one of the important diseases that endanger the pig industry. Pigs of all ages and sexes are susceptible to porcine pseudorabies virus. The infection of newborn piglets can lead to 100% mortality, which has caus...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K36/185A61P31/22
CPCA61K31/715A61K36/185A61P31/22
Inventor 郇长超张伟刘金彪尼博高崧
Owner YANGZHOU UNIV
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