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Application of egcg in the preparation of preparations for preventing and/or treating prv infection, preparations for preventing and/or treating prv infection

A preparation and solvent technology, applied in the field of porcine pseudorabies virus infection treatment, can solve the problem of no effective treatment measures for mutant PRV, and achieve the effects of no toxic and side effects, easy availability of raw materials and wide drug sources

Active Publication Date: 2021-03-30
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no effective treatment for mutated PRV in my country, and the occurrence of the disease can only be controlled by early prevention and strengthening health management.

Method used

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  • Application of egcg in the preparation of preparations for preventing and/or treating prv infection, preparations for preventing and/or treating prv infection
  • Application of egcg in the preparation of preparations for preventing and/or treating prv infection, preparations for preventing and/or treating prv infection
  • Application of egcg in the preparation of preparations for preventing and/or treating prv infection, preparations for preventing and/or treating prv infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation for preventing and / or treating porcine pseudorabies virus infection, which is obtained by dissolving epigallocatechin gallate in 0.1mol / L PBS buffer solution, and the concentration of epigallocatechin gallate is 50mmol / L L.

Embodiment 2

[0033] A preparation for preventing and / or treating porcine pseudorabies virus infection, which is obtained by dissolving epigallocatechin gallate in 0.15mol / L PBS buffer solution, and the concentration of epigallocatechin gallate is 40mmol / L L.

Embodiment 3

[0035]A preparation for preventing and / or treating porcine pseudorabies virus infection, which is obtained by dissolving epigallocatechin gallate in 0.1mol / L PBS buffer solution, and the concentration of epigallocatechin gallate is 100mmol / L L.

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PUM

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Abstract

The invention provides the application of epigallocatechin gallate in the preparation of preparations for preventing and / or treating porcine pseudorabies virus infection and the preparation for preventing and / or treating porcine pseudorabies virus, belonging to the technical field of porcine pseudorabies virus infection treatment , the concentration of epigallocatechin gallate in the medicine is 10-100 μmol / L. In the present invention, the anti-porcine pseudorabies virus infection effect of the epigallocatechin gallate is very significant: the epigallocatechin gallate can reduce the cytopathy caused by the porcine pseudorabies virus and inhibit the porcine pseudorabies virus Adsorption, entry and replication of porcine pseudorabies virus, and can directly kill porcine pseudorabies virus, more importantly, epigallocatechin gallate can prevent and / or treat mice infected with porcine pseudorabies virus. Pseudorabies provides a scientific and reliable theoretical basis.

Description

technical field [0001] The invention belongs to the technical field of porcine pseudorabies virus infection treatment, in particular to the application of epigallocatechin gallate in the preparation of preparations for preventing and / or treating porcine pseudorabies virus infection and the preparation for preventing and / or treating porcine pseudorabies virus . Background technique [0002] Porcine pseudorabies virus is a linear double-stranded DNA molecule belonging to the family Herpesviridae and the genus Porcine Herpesvirus. Pseudorabies virus is pantropic and can proliferate in a variety of tissue culture cells, among which rabbit kidney and pig kidney cells (including the original first-generation cells and second-generation cell lines) are the most sensitive and cause obvious cytopathic changes. Pigs are the storage hosts of pseudorabies virus, and sick pigs, infected pigs and infected rodents are the main sources of infection for this disease. In pig herds, the viru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61P31/20
CPCA61K31/353A61P31/20
Inventor 郇长超徐伟音郭停停高崧
Owner YANGZHOU UNIV
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