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Biomarkers for a systemic lupus erythematosus (SLE) disease activity immune index that characterizes disease activity

A biomarker, lupus erythematosus technology, applied in the direction of biological testing, disease diagnosis, biomaterial analysis, etc.

Pending Publication Date: 2021-07-30
OKLAHOMA MEDICAL RES FOUND
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, to date, the paucity of disease management tests that inform immune mechanisms in SLE stems from the absence of a single immune pathway-informed biomarker that serves as a universal surrogate for concurrent or future clinical disease activity (38)

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  • Biomarkers for a systemic lupus erythematosus (SLE) disease activity immune index that characterizes disease activity
  • Biomarkers for a systemic lupus erythematosus (SLE) disease activity immune index that characterizes disease activity
  • Biomarkers for a systemic lupus erythematosus (SLE) disease activity immune index that characterizes disease activity

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Embodiment Construction

[0027] While the making and using of various embodiments of the invention are discussed in detail below, it should be recognized that the present invention provides many applicable inventive concepts that can be embodied in a wide variety of specific contexts. The specific embodiments discussed herein are merely illustrative of specific ways to make and use the invention, and do not delineate the boundaries of the scope of the invention.

[0028] In order to facilitate the understanding of the present invention, various terms are defined below. Terms defined herein have meanings commonly understood by those of ordinary skill in the fields relevant to the present invention. Terms such as "a", "an" and "the" are not intended to refer to only a single entity, but include general categories, specific instances of which may be used for illustration. The terminology herein is used to describe specific embodiments of the invention, but their usage does not delimit the invention, exc...

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Abstract

The present invention includes a method of characterizing disease activity in a systemic lupus erythematosus patient (SEE), comprising: obtaining a dataset associated with a blood, serum, plasma or urine sample from the patient, wherein the dataset comprises data representing the level of one or more biomarkers in the blood, serum, plasma or urine sample from each of (b) to (g); at least one innate serum or plasma mediator biomarker; at least one adaptive serum or plasma mediator; at least one chemokine / adhesion molecule biomarker; at least one soluble TNF superfamily biomarker; the inflammatory mediator biomarker SCF; at least one SLE-associated autoantibody specificity biomarker; and calculating a Lupus Disease Activity Immune Index (LDAII) score.

Description

technical field [0001] The present invention relates generally to the field of biomarkers for calculating a Lupus Disease Activity Immune Index characterizing disease activity in systemic lupus erythematosus (SLE). [0002] Statement of Federally Funded Research [0003] Not applicable. [0004] References to Sequence Listings [0005] Not applicable. Background technique [0006] Without limiting the scope of the invention, its background is described in relation to systemic lupus erythematosus (SLE). [0007] Systemic autoimmune diseases, including SLE, afflict a large portion of the U.S. population. Recent population-based studies reflect a prevalence of 73 / 100,000 (1, 2), while the Lupus Foundation of America estimates the likely number of SLE patients in routine clinical practice to be as high as 470 / 100,000. SLE presents with a spectrum of clinical symptoms; disease classification depends on the fulfillment of 4 of 11 American College of Rheumatology (ACR) criteri...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/564G01N33/68G01B5/00
CPCG01N33/564G01N2800/52G01N2800/56G01N2800/104G16H50/20G01N2333/52G16H50/30Y02A90/10G01N33/6803
Inventor 朱迪斯·安·詹姆斯梅利莎·伊丽莎白·芒罗
Owner OKLAHOMA MEDICAL RES FOUND
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