Freeze-dried excipient protection device and preparation method thereof

Abstract

The invention relates to a freeze-dried excipient protection device and a preparation method thereof. The freeze-dried excipient protection device is characterized by comprising three cavities with two open ends, an outer shell, a freeze-dried excipient, a rotating shaft, a connecting cylinder and a connecting sleeve; the rotating shaft is horizontally and rotatably connected to the center in the outer shell; the connecting cylinder is sleeved on the rotating shaft and rotates along with the rotating shaft; the cavity is composed of a storage section used for storing the freeze-dried excipient, an inlet connecting section and an outlet connecting section, the inlet connecting section and the outlet connecting section are connected to the left end and the right end of the storage section, and the left side and the right side of the upper end of the outer shell are provided with an inlet end and an outlet end respectively; and telescopic joints are arranged between the inlet end and the inlet connecting section as well as between the outlet end and the outlet connecting section. The defects that a traditional freeze-dried excipient is low in hardness and easy to break and needs to be taken out manually to cause secondary pollution are essentially overcome, the preparation cost can be reduced, and the yield can be increased.

Description

technical field [0001] The invention relates to a freeze-dried excipient preparation protection device and a preparation method thereof, in particular to a freeze-dry excipient preparation protection device and a preparation method of the freeze-dry excipient preparation. Background technique [0002] Freeze-drying excipient technology refers to adding a skeleton support agent and a binder to a flowable liquid, semi-solid or solid active ingredient, or the flowable liquid, semi-solid or solid itself contains a binder and a skeleton The support agent is then poured into a molding mold and shaped by a freeze-drying process. The preparation prepared by the freeze-drying excipient technology is called a freeze-dried excipient preparation. [0003] Because this type of preparation adopts a freeze-drying process, which can protect heat-sensitive components from being destroyed, and at the same time produce a large number of micropores and channels through water sublimation, it can...

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a freeze-dried excipient containing a binder and a protection device for the freeze-dried excipient, which essentially solves the above-mentioned traditional freeze-dried excipients with low hardness, easy breakage, secondary pollution caused by manual removal, etc. Preparation defects can not only reduce preparation cost, improve yield, but also reduce packaging cost and realize automatic production

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