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Detection kit for detecting variant new coronavirus and application thereof

A technology of detection kits and test strips is applied in the field of detection kits for detecting mutated new coronaviruses, which can solve the problems of long detection time, high cost, and unfavorable rapid census for detection of all infected persons.

Pending Publication Date: 2021-08-06
上海中冶医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the method of diagnosing the mutated new coronavirus is mainly the whole gene sequencing method, but this method is costly, and the key is that the detection time is long, which is not conducive to the detection of all infected persons and rapid census in the population

Method used

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  • Detection kit for detecting variant new coronavirus and application thereof
  • Detection kit for detecting variant new coronavirus and application thereof
  • Detection kit for detecting variant new coronavirus and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0053] (1) Take the nitrocellulose membrane and cut it into 25mm×300mm to obtain the chromatographic membrane;

[0054] Take absorbent paper and cut it into 17mm×300mm thin strips to obtain absorbent pads.

[0055] Take the sample pad, cut it into thin strips of 9mm×300mm, mix the RBD polyantibody evenly, spread it on the sample pad, put it in an oven and bake it at 37°C for 2 hours; obtain the sample pad coated with RBD polyantibody;

[0056] Take the gold standard pad, which is coated with chicken IgY-labeled gold particles, chicken NP-antibody II-labeled gold particles and RBD-labeled gold particles;

[0057] (2) The sample pad, gold standard pad, chromatographic membrane (nitrocellulose membrane) and water-absorbent pad are lapped and bonded on the bottom plate from left to right; the rabbit anti-chicken IgY is diluted with PBS to a concentration of 1mg / ml, As a C-line coating solution; dilute ACE2 protein with PBS to a concentration of 1mg / ml, as a T1 detection line coat...

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Abstract

The invention discloses a detection kit for detecting variant new coronavirus and application thereof. The detection kit comprises detection test paper, the detection test paper comprises a bottom plate, a chromatography membrane, a sample pad, a gold label pad and a water absorption pad, and the sample pad, the gold label pad, the chromatography membrane and the water absorption pad are sequentially overlapped and bonded to the bottom plate from left to right; a T1 detection line, a T2 detection line and a C line are sequentially arranged on the nitrocellulose membrane from left to right; and the T1 detection line, the T2 detection line and the C line are arranged at intervals. The invention creatively designs a detection kit capable of distinguishing and detecting the variant new coronavirus and the common new coronavirus aiming at the variant new coronavirus and the common new coronavirus, and by adopting the kit provided by the invention, the variant new coronavirus infected persons can be effectively distinguished; and the detection kit has good specificity and sensitivity during detection, is simple, rapid and accurate to operate, and provides positive help for diagnosis, treatment, prevention and control of the new coronal pneumonia.

Description

technical field [0001] The invention relates to the technical field of novel coronavirus detection, in particular to a detection kit for detecting mutated novel coronavirus and its application. Background technique [0002] At present, more than 40 countries around the world have found mutated new coronaviruses. Henry Walker, head of the new crown epidemic at the US Centers for Disease Control and Prevention, pointed out that new coronaviruses often mutate, and over time, there may be more mutated viruses. The mutated virus is more contagious, spreads faster, causes the same severity of illness and is partially ineffective against vaccination. If controls are not tightened to slow its spread, it will have a greater impact on an already stressed healthcare system. [0003] In mid-December, the UK reported for the first time a highly contagious mutant strain of the new coronavirus: the B.1.1.7 strain, which soon became the main strain in the London area. [0004] As of Decem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/577G01N33/569G01N33/58G01N33/558
CPCG01N33/558G01N33/56983G01N33/577G01N33/587G01N2333/165G01N2469/10
Inventor 李仁杰罗朝领徐灵张宇亮吴成志陆文源
Owner 上海中冶医院
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