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Plant antibiotic and preparation method and use thereof

A plant antibiotic and drug technology, applied in the field of medicine, can solve the problems of no prevention and treatment of new coronavirus pneumonia, antiviral chemical drug resistance, adverse reactions, etc., to improve resource utilization, speed up healing, and improve strong penetration. Effect

Pending Publication Date: 2021-08-20
王贵林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the stubbornness and recurrence of the new coronavirus pneumonia disease, commonly used antiviral chemical drugs have problems such as drug resistance, adverse reactions, and high prices. So far, there is no specific drug for the prevention and treatment of new coronavirus pneumonia

Method used

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  • Plant antibiotic and preparation method and use thereof
  • Plant antibiotic and preparation method and use thereof
  • Plant antibiotic and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: prepare plant antibiotic of the present invention

[0064] Raw material preparation:

[0065]

[0066]Step 1: remove impurity, wash, chop, mix, add Soak in 2-3 times the amount of ethanol (concentration 95%) for 10 hours, heat and reflux extraction three times, the reflux extraction time is 6 hours, filter, recover the ethanol from the filtrate to obtain the filtrate, concentrate at 75°C to a thick juice with a specific gravity of 0.80-1.10 for later use;

[0067] Step 2: Remove impurities and wash gallnuts, dark plums, Phellodendron cork, hawthorn, basil, jujube, Luo Han Guo, loquat, grind and mix, add ethanol (concentration 95%) by 5-6 times the weight, reflux extraction three times, and reflux time 4 hours; filter, recover ethanol from the filtrate, and concentrate at 65°C to a thick paste with a relative density of 1.15 for later use;

[0068] Step 3: Mix the juice and thick paste obtained in the above steps 1 and 2, put them in a hot reflux extra...

Embodiment 2

[0073] Embodiment 2: preparation plant antibiotic

[0074] Raw material preparation:

[0075]

[0076] Step 1: remove impurity, wash, chop, mix, add Soak in 2-3 times the amount of 90% ethanol for 8 hours, heat and reflux extraction three times, the reflux extraction time is 4 hours, filter, recover the ethanol from the filtrate to obtain the filtrate, concentrate at 65°C to a thick juice with a specific gravity of 0.80 for later use;

[0077] Step 2: Wash gallnuts, dark plums, Phellodendron cortex, hawthorn, Baibu, jujube, Luo Han Guo, loquat to remove impurities, grind and mix, add ethanol solution with a volume concentration of 95% according to 5 times the weight, and reflux extraction three times, reflux time 3 hours; filter, recover ethanol from the filtrate, concentrate at 55°C to a thick paste with a relative density of 1.00 for later use;

[0078] Step 3: Mix the juice and thick paste obtained in the above steps 1 and 2, put them in a hot reflux extraction kettle,...

Embodiment 3

[0083] Embodiment 3: Microbiological limit test of the plant antibiotic preparation of the present invention.

[0084] Basis: This product is in accordance with the "Chinese Pharmacopoeia" 2005 edition of the second appendix ⅪJ microbial limit inspection method inspection standard: the number of bacteria should not exceed 100 per 1g, the number of molds and yeasts should not exceed 100 per 1g, and the number of Pseudomonas aeruginosa should not exceed 100 per gram. 1g shall not be detected, Staphylococcus aureus shall not be detected per 1g.

[0085] Preparation of test solution:

[0086] Take 5g of the test product, put it in a sterile Erlenmeyer flask, add 8ml of sterile Tween-80 in a constant temperature water bath at 45°C, and stir well, then slowly add sterile chlorine with a pH of 7.0 preheated to 45°C Sodium NaCl-Peptone buffer solution to a total volume of 100ml, add while shaking to mix and shake for 5 to 10 minutes, it will be in the form of a white emulsion as a 1:...

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Abstract

The invention relates to the field of medicines and discloses a plant antibiotic. The plant antibiotic is prepared from rhizoma polygonati, rhizoma curcumae, fructus gardeniae, liquorice, folium artemisiae argyi, radix morindae officinalis, poria cocos, rhizoma atractylodis macrocephalae, tremella fuciformis, malt, cortex magnoliae officinalis, fructus momordicae, gallnut, dark plum, cortex phellodendri, haws, radix stemonae, Chinese dates, selaginella tamariscina and loquat. The invention also provides a preparation method and use of the plant antibiotic.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a plant antibiotic and a preparation method thereof, as well as its use in the preparation of medicines for treating diseases caused by novel coronavirus or hand-foot-mouth virus. Background technique [0002] In recent years, the epidemic of plague affecting the health of all mankind has become a global social problem. At present, medical research institutions in various countries are actively developing various medical products for the prevention and treatment of epidemics. In view of the limitations of western medicine, people have gradually turned their attention to the development of natural plant and Chinese herbal medicines represented by traditional Chinese medicine. [0003] The acute respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) is highly contagious and epidemic. The current...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P31/14A61P17/02A61P1/02A61K35/64
CPCA61K36/8969A61K36/9066A61K36/744A61K36/484A61K36/282A61K36/746A61K36/076A61K36/284A61K36/07A61K36/8998A61K36/575A61K36/42A61K35/64A61K36/736A61K36/756A61K36/734A61K36/904A61K36/725A61K36/11A61K36/73A61P31/14A61P17/02A61P1/02A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/19A61K2300/00Y02A50/30
Inventor 王贵林
Owner 王贵林
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