Rapid cross-linking and degradable peg powder and its application

A fast, starchy technology, applied in applications, surgery, drug delivery, etc., can solve the problems of no interaction between tissues, inconvenient use, easy to break, etc., and achieve good biocompatibility.

Active Publication Date: 2022-06-17
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the jelly formed by the hemostatic powder is not strong enough and is easily broken under the impact of the blood flow at the wound; the hemostatic powder does not interact with the tissue at the wound, and must be specially fixed during use, resulting in inconvenient

Method used

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  • Rapid cross-linking and degradable peg powder and its application
  • Rapid cross-linking and degradable peg powder and its application
  • Rapid cross-linking and degradable peg powder and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Weigh 130mg four-arm polyethylene glycol amino group (as shown in formula II, wherein m is 36), the particle size is 1 μm, and weigh 120mg four-arm polyethylene glycol succinimide ester (as shown in formula VI, Wherein, n is 46), the particle size is 2 μm, two kinds of PEG powders and 100 mg of Fuhetai degradable hemostatic powder are mixed uniformly to obtain composite hemostatic powder.

[0049] Degradation test: Put the composite hemostatic powder after water absorption into 10 times the mass of PBS solution, then put it into a constant temperature shaker at 37±1°C, and observe the gel sample in the buffer solution at a speed of 100r / min. Change the situation, until the time of centrifugation and no precipitation is seen, which is recorded as the gel in vitro degradation time.

[0050] Absorption test: Mix a certain quality of hemostatic powder and spread it in a petri dish, and add ultrapure water to the petri dish to immerse the hemostatic powder. The gelled hemos...

Embodiment 2

[0057] Weigh 200mg four-arm polyethylene glycol amino group (as shown in formula II, wherein m is 123), and the particle size is 0.2 μm, weigh 200mg four-arm polyethylene glycol succinimide ester (as shown in formula VI) , where n is 112), the particle size is 0.5 μm, and the two kinds of PEG powders are mixed with 200 mg of melast quick-acting hemostatic powder uniformly to obtain compound hemostatic powder.

[0058] The composite hemostatic powder prepared in this example has a water absorption capacity of 150 times, which is far greater than the water absorption capacity (53 times) of the single commercially available Methast quick-acting hemostatic powder. It is attached to the surface of the skin, and the in vitro degradation time is 3 days.

Embodiment 3

[0060] Weigh 100mg six-arm polyethylene glycol amino group (as shown in formula III, wherein m is 38), the particle size is 0.2 μm, and weigh 200mg two-arm polyethylene glycol succinimide ester (as shown in formula V) , where n is 46), the particle size is 1.5 μm, and the two kinds of PEG powders are mixed with 500 mg Arista TM hemostatic powder uniformly to obtain a composite hemostatic powder.

[0061] The composite hemostatic powder prepared in this example has a water absorption capacity of 73 times, which is close to the water absorption capacity (70 times) of the single commercially available Arista TM hemostatic powder. On the surface of the skin, the in vitro degradation time was 4 days.

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Abstract

The invention provides PEG powder capable of rapid cross-linking and degradation and its application. The composite hemostatic powder is composed of polyethylene glycol derivative 1, polyethylene glycol derivative 2 and commercially available hemostatic powder. Substance 1 and polyethylene glycol derivative 2 can react with each other to form a gel in the presence of blood, which enhances the strength of the hemostatic powder and the ability to interact with tissues. The compound hemostatic powder can absorb a large amount of water, and the degradation time can be adjusted to be suitable for different bleeding locations and bleeding degrees.

Description

technical field [0001] The invention relates to a compound hemostatic powder system, in particular to a compound hemostatic powder system based on rapidly crosslinkable and degradable PEG powder and commercially available hemostatic powder, and a preparation method and application thereof. Background technique [0002] Trauma is the leading cause of death among individuals between the ages of 1 and 44, and blood loss is a major cause of death, both in daily life and on the battlefield. Especially on the battlefield, timely intervention to stop bleeding is the key to improve the survival rate of individuals. The current hemostasis methods mainly include pressure hemostasis and local application of hemostatic materials to stop bleeding, but both of these methods are difficult to take effect on internal bleeding. In contrast, hemostatic powder has attracted attention because of its ability to handle large blood flow and to completely cover the wound. After the hemostatic powd...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L24/02A61L24/04C08J3/24C08L71/02
CPCA61L24/043A61L24/0015A61L24/0042A61L24/046A61L24/02C08J3/246A61L2400/04A61L2300/418C08J2371/02C08J2471/02C08L1/286C08L5/08C08L71/02
Inventor 吴德成叶慧君潘正
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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