Application of methyl caffeate and triazole composition in preparation of antifungal products

A technology of caffeic acid methyl ester and triazoles, which is applied in the direction of antifungal agents, chemicals for biological control, applications, etc., and can solve problems such as rising drug resistance rates

Active Publication Date: 2021-09-14
MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problem that the antifungal drugs in the prior art mainly use triazoles, which leads to the rising rate of drug resistance

Method used

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  • Application of methyl caffeate and triazole composition in preparation of antifungal products
  • Application of methyl caffeate and triazole composition in preparation of antifungal products
  • Application of methyl caffeate and triazole composition in preparation of antifungal products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Methyl caffeate and triazoles joint antifungal action assay

[0044] 1. Materials

[0045] 1.1 Drugs and reagents

[0046] Methyl Caffeate (MC), Dalian Meilun Biotechnology Co., Ltd.;

[0047] Itraconazole (ITR), Dalian Meilun Biotechnology Co., Ltd.;

[0048] Voriconazole (Voriconazole, VRC), Dalian Meilun Biotechnology Co., Ltd.;

[0049] CHROMagar Candida Chromogenic Medium, Zhengzhou Bosai Biological Engineering Co., Ltd.;

[0050] TTC-Sa Paul medium, Qingdao Hi-tech Park Haibo Biotechnology Co., Ltd.;

[0051] Yeast paste, Beijing Aoboxing Biotechnology Co., Ltd.;

[0052] Peptone, Beijing Aoboxing Biotechnology Co., Ltd.;

[0053] Glucose, Sinopharm Chemical Reagent Co., Ltd.;

[0054] Agar powder, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0055] PBS phosphate buffer, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0056] Sodium hydroxide, state-owned Shandong Shanxian Organic Chemical Factory, batch number 940420;

[0057] Po...

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Abstract

The invention belongs to the technical field of antifungal drug combination, and particularly provides application of methyl caffeate and a triazole composition in preparation of antifungal products. Specifically, the invention provides application of methyl caffeate in preparation of antifungal drugs, and fungi are non-candida albicans, preferably candida glabrata or candida krusei or mixed bacteria of the candida glabrata and the candida krusei. The problem that in the prior art, triazole drugs are mainly adopted as antifungal drugs, and consequently the drug resistance rate continuously rises is solved.

Description

technical field [0001] The disclosure belongs to the technical field of combined antifungal drugs, and specifically provides the application of methyl caffeate and triazole compositions in the preparation of antifungal products. Background technique [0002] The statements herein merely provide background information related to the present disclosure and may not necessarily constitute prior art. [0003] In recent years, fungal infections have been increasing year by year clinically, and can occur in different age groups, and the phenomenon of fungal drug resistance caused by irrational drug use has become more and more prominent, especially the rate of fungal drug resistance to azoles is as high as 65%, of which Candida is a common isolate of respiratory system, bloodstream infection, digestive system, and urinary system fungal infection. Data show that the problem of non-albicans drug resistance is particularly prominent. At present, there are limited varieties of antifu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61K31/4196A61K31/496A61K31/506A61K45/06A61P31/10A61P29/00A61K8/37A61K8/49A61Q17/00A61Q19/10A61Q5/02A61Q19/00A01N37/38A01P3/00
CPCA61K31/216A61K31/4196A61K31/496A61K31/506A61K45/06A61P31/10A61P29/00A61K8/37A61K8/496A61Q17/005A61Q19/10A61Q5/02A61Q19/005A01N37/38A61K2800/592A61K2300/00
Inventor 李秀云张秀荣谭冬梅耿炜张峰
Owner MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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