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Multi-parameter quantitative test system and method for tissue attributes

A technology of tissue properties and testing systems, applied in the field of medical devices, can solve the problems of large variability in multiple imaging, unfavorable tracking, etc.

Active Publication Date: 2021-09-14
TSINGHUA UNIV
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Problems solved by technology

[0002] The disadvantage of non-quantitative imaging is that the diagnosis of diseases and lesions depends on the signal intensity of other surrounding tissues, and is very susceptible to the influence of scanning equipment, imaging parameters, image interpretation personnel, etc., and the variation between multiple imaging of the same tissue It is not conducive to the comparison between multiple scans and the tracking of disease development process, so robust quantitative imaging has always been a research hotspot

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[0041]In order to make the purpose, technical solutions and advantages of the application clearer, the application will be further described in detail below in conjunction with the accompanying drawings. All other embodiments obtained under the premise of creative labor belong to the scope of protection of this application.

[0042] In the following description, references to "some embodiments" describe a subset of all possible embodiments, but it is understood that "some embodiments" may be the same subset or a different subset of all possible embodiments, and Can be combined with each other without conflict.

[0043] If there is a similar description of "first\second\third" in the application documents, add the following explanation. In the following description, the term "first\second\third" is only to distinguish similar Objects do not represent a specific order for objects. It is understandable that "first\second\third" can be exchanged for a specific order or sequence i...

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Abstract

The invention provides a multi-parameter quantitative test system and method for tissue attributes. The system comprises: a scanning module used for scanning a subject based on a preset sequence, wherein the preset sequence comprises a flip recovery preparation IR pulse, a T2 preparation pulse and a series of excitation pulses; an acquisition module used for acquiring single-gradient echo data and multi-gradient echo data in a scanning process, wherein the single-gradient echo data and the multi-gradient echo data comprise sampling spokes; a reconstruction module used for performing reconstruction based on sampling spokes corresponding to different T2 preparation pulses T2prep and different flip moments TI in the single-gradient echo data to obtain a plurality of first weighted images including T2 and T1, and performing reconstruction based on sampling spokes corresponding to different acquisition moments TE in the multi-gradient echo data to obtain a plurality of second weighted images of T2*; and a fitting module used for fitting based on the first weighted image to obtain a T2 value and a T1 value of the tissue, and fitting based on the second weighted image to obtain a T2* value of the tissue.

Description

technical field [0001] The present application relates to the technical field of medical devices, in particular to a multi-parameter quantitative testing system for tissue attributes and a method thereof. Background technique [0002] The disadvantage of non-quantitative imaging is that the diagnosis of diseases and lesions depends on the signal intensity of other surrounding tissues, and is very susceptible to the influence of scanning equipment, imaging parameters, image interpretation personnel, etc., and the variation between multiple imaging of the same tissue Therefore, robust quantitative imaging has always been a research hotspot. By using a variety of imaging sequences, flexibly adjusting imaging parameters, and using a variety of endogenous and exogenous contrast agents, magnetic resonance imaging can obtain a variety of quantitative parameters reflecting tissue properties, so it is very suitable for quantitative imaging. Magnetic resonance quantitative imaging me...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/48G01R33/54A61B5/055
CPCG01R33/48G01R33/54A61B5/055
Inventor 陈慧军王雅洁李雨泽窦佳琦杨润宇
Owner TSINGHUA UNIV
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