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Lonicera japonica flower water extract-containing pharmaceutical composition for preventing or treating helicobacter pylori infection

A Helicobacter pylori, water extract technology, applied in antibacterial drugs, applications, pharmaceutical formulations, etc., can solve problems such as increased antibiotic resistance, achieve excellent antibacterial effects, reduce the expression of Helicobacter pylori IgG antibodies, reduce Effects of histopathological lesions

Pending Publication Date: 2021-09-21
GREEN CROSS HEALTH SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, repeated use of these drugs has been reported to cause increased antibiotic resistance and various side effects, and currently, ongoing efforts are being made to find extracts and active ingredients that can inhibit Helicobacter pylori using various natural substances

Method used

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  • Lonicera japonica flower water extract-containing pharmaceutical composition for preventing or treating helicobacter pylori infection
  • Lonicera japonica flower water extract-containing pharmaceutical composition for preventing or treating helicobacter pylori infection
  • Lonicera japonica flower water extract-containing pharmaceutical composition for preventing or treating helicobacter pylori infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]

[0034] 2000 ml of water was added to 100 g of honeysuckle, and extracted with hot water at 90° C. for 3 hours to obtain 1400 ml of honeysuckle extract. The extract was filtered through a 5 μm filter paper, and then concentrated at 50° C. under reduced pressure for 3 hours. After that, the concentrate was dried overnight at 50° C. under reduced pressure to obtain 25 g of the honeysuckle aqueous extract in Example 1 of the present invention.

Embodiment 2

[0035]

[0036] 2000 ml of water was added to 100 g of honeysuckle, and extracted with hot water at 90° C. for 1 hour to obtain 1400 ml of honeysuckle extract. The extract was filtered through a 5 μm filter paper, and then concentrated at 50° C. under reduced pressure for 3 hours. After that, the concentrate was dried overnight at 50° C. under reduced pressure to obtain 25 g of the honeysuckle aqueous extract in Example 2 of the present invention.

Embodiment 3

[0037]

[0038] 2000 ml of water was added to 100 g of honeysuckle, and extracted with hot water at 90° C. for 5 hours to obtain 1400 ml of honeysuckle extract. The extract was filtered through a 5 μm filter paper, and then concentrated at 50° C. under reduced pressure for 3 hours. After that, the concentrate was dried overnight at 50° C. under reduced pressure to obtain 25 g of the honeysuckle aqueous extract in Example 3 of the present invention.

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Abstract

The present invention pertains to a Lonicera Japonica flower water extract composition for preventing or treating Helicobacter pylori infection, the composition containing secoxyloganin as an active ingredient. The extract contains a specific amount of secoxyloganin, and thus exhibited excellent antibacterial effects when used on Helicobacter pylori bacteria, and exhibited excellent effects in terms of reducing Helicobacter pylori IgG antibody expression in the blood, alleviating histopathological lesions, and reducing cytokine expression when used on Helicobacter pylori-infected mice. Thus, the Lonicera Japonica flower water extract of the present invention can be usefully used as a composition for preventing or treating Helicobacter pylori infection.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing or treating Helicobacter pylori infection comprising honeysuckle flower water extract. Background technique [0002] Helicobacter pylori (H.Pylori) was first discovered in 1983 by Marshall and Warren in Australia. Helicobacter pylori is a helical microaerophilic gram-negative bacterium with 4 to 6 flagella and has been reported to infect more than half of the world's population, and in Korea, adults over 40 years of age have been reported to have The infection rate is over 70%. Helicobacter pylori is mainly known as a pathogenic microorganism closely related to upper gastrointestinal diseases, causing chronic gastritis, gastroduodenal ulcer, gastric cancer, etc. In particular, the International Institute for Cancer Research (IARC) and the World Health Organization define Helicobacter pylori as a class I carcinogen. In the prevention and diagnosis of gastric cancer, the infection of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61K31/7048A61P31/04A23L33/105
CPCA23L33/105A61K36/355A61K31/7048A61P31/04A23V2002/00A23V2200/324A23P10/28A23P10/30A23L2/52
Inventor 金点溶朴宣奎张珉廷李宗勋林洙焕
Owner GREEN CROSS HEALTH SCI
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