Improved methods for angiography

A technology of angiography and contrast agents, which is applied in the direction of radiological diagnosis equipment, X-ray contrast agent preparation, MRI/MRI contrast agents, etc., which can solve the problems of increasing the risk of complications

Pending Publication Date: 2021-09-21
威廉 E 巴特勒
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The need to advance the injection catheter further increases the risk of complications from catheter damage to smaller vessels distal to the vascular tree

Method used

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  • Improved methods for angiography
  • Improved methods for angiography
  • Improved methods for angiography

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Embodiment Construction

[0021] The compositions and methods provided by the present invention allow acquisition of angiographic images and information while navigating using lower intravascular contrast agent doses, lower x-ray doses, and / or shorter distances for catheters injecting contrast agents into the vascular tree. These methods use data processing techniques applied to angiography to generate a spatiotemporal reconstruction (eg, using wavelets), also known as a beat space angiography. See US Patent No. 10,123,761, the entire contents of which are hereby incorporated by reference in their entirety. As described herein, the present technique exploits the heart rate phase (including coherence) and organization of heart rate from beat space angiography for reduction of x-ray exposure and / or contrast agent dose and catheter positioning. The presence of angiographic coherence increases the net signal in the captured data, and the increase in net signal reduces or eliminates the need for increased s...

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Abstract

The discovery that contrast in blood vessels varies at cardiac frequency in magnitude and phase enables a set of processes for increasing the signal to noise ratio or equivalently the informational content of an angiogram. In this invention, the organization of cardiac frequency magnitude and phase enables equivalent information on anatomy and physiology to be obtained with less dose of injected chemical contrast agent, less x-ray dose, and / or less navigation of the injecting catheter within blood vessels. The cardiac frequency magnitude and phase is organized so that the arterial and venous subsystems of circulation have coherence at cardiac frequency. This enables processes for diagnosing deficits of circulation that involve alterations in the transit of blood from the arterial to the venous subsystems of circulation. Furthermore, the discovery of cardiac frequency magnitude and phase organization enables the design and manufacture of lighter and more portable angiography equipment.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application No. 62 / 801,780, filed February 6, 2019, the entire contents of which are incorporated herein by reference in their entirety. technical field [0003] Improved methods for angiography are provided. In particular, methods of acquiring angiographic data are provided which allow the use of significantly reduced contrast agent doses and / or x-ray doses while maintaining or improving the signal-to-noise ratio of angiography. Background technique [0004] In conventional catheter angiography, a catheter is placed in an artery and the tip of the catheter is advanced into the artery region of interest. A chemical contrast agent is injected, and the entry of the contrast agent into the vascular bed is imaged and recorded by fluoroscopy. Contrast agents are x-ray opaque such that an opaque pattern appears on the imaging x-ray detector in a series of angiographic im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/02A61K47/02A61K49/04A61K49/08A61B6/00
CPCA61B6/481A61B6/503A61B6/504A61B6/5258A61B6/542A61B6/5211A61B6/4441A61B6/487G06T5/002G06T5/50G06T7/0016G06T2207/10016G06T2207/10116G06T2207/30101A61B6/485A61B6/5217A61B6/5288A61K49/04A61B6/5205
Inventor 威廉·E·巴特勒
Owner 威廉 E 巴特勒
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