A kind of plant extract combined dressing based on ginseng extract and preparation method thereof

A plant extract, ginseng extraction technology, applied in bandages, absorbent pads, medical science and other directions, can solve the problems of poor air permeability, reduce the air permeability of chitosan film, wound healing effects, etc., achieve good stability, no side effects sterilization Excellent efficacy, antibacterial and bacteriostatic effect

Active Publication Date: 2022-06-28
吉林省蓝浦浩业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Because chitosan has excellent non-toxic, antibacterial, and biocompatibility, chitosan film is generally used as dressing base film, and polydopamine layer is coated on the surface of chitosan film to increase the load of subsequent particles. effect, but the existence of polydopamine layer will reduce the air permeability of chitosan film, the air permeability is poor in actual use, which will affect wound healing

Method used

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  • A kind of plant extract combined dressing based on ginseng extract and preparation method thereof
  • A kind of plant extract combined dressing based on ginseng extract and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] A preparation method of a plant extract combination dressing based on ginseng extract, comprising the following steps:

[0042] (1) get zinc nitrate hexahydrate and ethanol, mix and stir for 20min, add ethyl orthosilicate, stir to obtain material C;

[0043] Take cetyltrimethylammonium bromide and deionized water, mix and stir for 5 minutes, add ether, ethanol and ammonia water, continue stirring for 30 minutes, slowly add material C and 3-mercaptopropyltrimethoxysilane dropwise, and stir for 4 hours , the product was collected by centrifugation, washed with ethanol and deionized water in turn, and dried under vacuum at 60 °C; after drying, it was transferred to a mixed solution of ethanol and hydrochloric acid, refluxed for 24 h at 68 °C, washed and dried to obtain mesoporous silica.

[0044] Take mesoporous silica and N,N-dimethylformamide, disperse by ultrasonic for 10min, get material B; take KH-550, succinic anhydride and N,N-dimethylformamide, disperse by ultrason...

Embodiment 2

[0053] A preparation method of a plant extract combination dressing based on ginseng extract, comprising the following steps:

[0054] (1) get zinc nitrate hexahydrate and ethanol, mix and stir for 25min, add ethyl orthosilicate, stir to obtain material C;

[0055] Take cetyltrimethylammonium bromide and deionized water, mix and stir for 8min, add ether, ethanol and ammonia water, continue to stir for 35min, slowly add material C and 3-mercaptopropyltrimethoxysilane dropwise, and stir for 5h , the product was collected by centrifugation, washed with ethanol and deionized water in turn, and dried in vacuum at 63 °C; after drying, it was transferred to a mixed solution of ethanol and hydrochloric acid, refluxed for 22 h at 69 °C, washed and dried to obtain mesoporous silica.

[0056] Take mesoporous silica and N,N-dimethylformamide, ultrasonically disperse for 13 minutes to obtain material B; take KH-550, succinic anhydride and N,N-dimethylformamide, ultrasonically disperse for ...

Embodiment 3

[0065] A preparation method of a plant extract combination dressing based on ginseng extract, comprising the following steps:

[0066] (1) get zinc nitrate hexahydrate and ethanol, mix and stir for 30min, add ethyl orthosilicate, stir to obtain material C;

[0067] Take cetyltrimethylammonium bromide and deionized water, mix and stir for 10min, add ether, ethanol and ammonia water, continue to stir for 40min, slowly add material C and 3-mercaptopropyltrimethoxysilane dropwise, and stir for 6h , the product was collected by centrifugation, washed with ethanol and deionized water in turn, and dried under vacuum at 65 °C; after drying, it was transferred to a mixed solution of ethanol and hydrochloric acid, refluxed for 20 h at 70 °C, washed and dried to obtain mesoporous silica.

[0068] Take mesoporous silica and N,N-dimethylformamide, ultrasonically disperse for 15 minutes to obtain material B; take KH-550, succinic anhydride and N,N-dimethylformamide, ultrasonically disperse ...

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Abstract

The invention discloses a plant extract combined dressing based on ginseng extract and a preparation method thereof. During preparation, the application first uses chitosan and polyoxyethylene as raw materials to prepare a chitosan film by electrospinning to obtain The chitosan film is used as the dressing base film. Because chitosan has the characteristics of non-toxicity, broad-spectrum antibacterial property, hemostasis, scar reduction and good biocompatibility, chitosan is selected as the main raw material, and Introduce plant extracts. The plant extracts of this application are ginseng extract + Ophiopogon japonicus extract, ginseng extract + chrysanthemum extract and ginseng extract + Artemisia annua extract. You can choose to mix and match at will. The invention has reasonable process design and simple operation, and the prepared combined dressing not only has excellent antibacterial performance, but also is non-toxic to human body, has good biocompatibility, and can promote skin surface wound healing when used, and has high practicability.

Description

technical field [0001] The invention relates to the technical field of dressings, in particular to a plant extract combined dressing based on ginseng extract and a preparation method thereof. Background technique [0002] Medical dressing is a widely used medical material nowadays. It is a medical material that can be tailored to the actual situation of the wound and provide special functions for wound healing. As a wound covering, medical dressings can replace damaged skin and act as a temporary barrier in the process of wound healing, which can avoid or control wound infection and provide a good healing environment for wounds. [0003] Because chitosan has excellent non-toxicity, antibacterial properties, and biocompatibility, chitosan film is generally used as the base film of the dressing, and a polydopamine layer is coated on the surface of the chitosan film to improve the loading of subsequent particles. However, the existence of the polydopamine layer will reduce the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/40A61L15/28A61L15/18A61L15/26A61L15/32A61L15/42A61L15/44A61L15/46
CPCA61L15/40A61L15/28A61L15/18A61L15/26A61L15/32A61L15/42A61L15/44A61L15/46A61L2300/30A61L2300/414A61L2300/254A61L2300/404A61L2300/236A61L2300/412A61L2300/602C08L5/08C08L79/02
Inventor 曹原徐阳眭春周兰夏翡翡
Owner 吉林省蓝浦浩业科技有限公司
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