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Method for determining residual quantity of chlorpromazine in honey

A determination method and chlorpromazine technology, which are applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of accumulation residues, leukopenia, agranulocytosis, etc., and achieve the effects of good precision and high accuracy

Pending Publication Date: 2021-10-01
上海冠生园蜂制品有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the metabolism of chlorpromazine is slow, and it is easy to accumulate residues in the body. Therefore, some chlorpromazine will remain in the honey produced by the bees that use chlorpromazine. When people eat honey with some chlorpromazine residues, it will cause human white blood cells reduction and agranulocytosis, adversely affecting human health

Method used

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  • Method for determining residual quantity of chlorpromazine in honey
  • Method for determining residual quantity of chlorpromazine in honey
  • Method for determining residual quantity of chlorpromazine in honey

Examples

Experimental program
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Embodiment 1

[0052] Embodiment 1: a kind of assay method of residual amount of chlorpromazine in honey is prepared by following steps:

[0053] (1) Sample pretreatment: Weigh 0.5kg of honey. When the honey has no crystals, take a sample directly. When the honey has crystals, heat it in a water bath at 40-60°C under airtight conditions. Stir evenly after the honey is completely melted. Cool to 25°C and seal for later use.

[0054] (2) Sample configuration: Weigh 2.00g sample with an analytical balance, add 20mL 0.05mol / L phosphate buffer solution, and mix with a liquid mixer for 1min at a speed of 60-70r / min to obtain a sample solution ;

[0055] Wherein, the preparation process of phosphate buffer solution is: take by weighing 5.68g disodium hydrogen phosphate and 1.36g potassium dihydrogen phosphate with analytical balance, place in 1000mL beaker, add 800mL water to dissolve, adjust to pH= 3.0, then dilute to 1000mL with water.

[0056] (3) Purification of the sample: the Oasis HLB sol...

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Abstract

The invention relates to the field of methods for detecting residual drugs in food, in particular to a method for determining the residual quantity of chlorpromazine in honey. The method comprises the following steps: (1) preparing a sample, (2) extracting a sample, (3) purifying the sample, (4) preparing a sample blank extracting solution of a chlorpromazine standard working solution, (6) carrying out liquid chromatography-tandem mass spectrometry measurement, (7) drawing a standard working curve, and (8) measuring the residual quantity of a measured substance in a pure sample product. The method provided by the invention is high in accuracy and good in precision, can meet the requirement of chlorpromazine residue analysis, and provides a powerful tool for detecting chlorpromazine in animal-derived food.

Description

technical field [0001] The application relates to the field of detection methods for residual drugs in food, more specifically, it relates to a method for determining the residual amount of chlorpromazine in honey. Background technique [0002] In recent years, with the improvement of people's living standards, animal husbandry has been gradually standardized and commercialized, and veterinary drugs and feed additives have been widely used in animal husbandry. For example, in order to obtain more economic benefits, beekeepers do not hesitate to overuse bee resources, which reduces the body resistance of bees and makes them vulnerable to stress and diseases. Therefore, in order to quickly restore bee productivity, beekeepers will rely on a large number of drugs to treat bees, and even use drugs in advance to prevent bee diseases, resulting in excessive veterinary drug residues in bee products. [0003] Chlorpromazine is a kind of veterinary drug. Chlorpromazine is called Don...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 李亮王蕾潘华钦彭扬平刘彩萍李云龙杨志伟崔宗岩
Owner 上海冠生园蜂制品有限公司
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