Uterine endometrial fluid for prediction of success in fertility treatment

A technology of endometrium and markers, applied in the field of fertility treatment, can solve the problem of not being able to test whether a woman's uterus will accept

Pending Publication Date: 2021-10-08
FERTILITY LAB SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the thickness of the endometrial lining is measured by ultrasound and blood reproductive hormones are monitored prior to frozen embryo transfer, so far it has not been possible to test whether a woman's uterus will accept

Method used

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  • Uterine endometrial fluid for prediction of success in fertility treatment
  • Uterine endometrial fluid for prediction of success in fertility treatment
  • Uterine endometrial fluid for prediction of success in fertility treatment

Examples

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example 1

[0065] Example 1: Maternal endometrial secretions 24 hours prior to frozen embryo transfer predict implantation outcome

[0066] Purpose: Implantation success depends on a complex dialogue between a competent embryo and a receptive endometrium. On the maternal side, adherence-specific biological changes are required for blastocyst attachment, and tight regulation of signaling pathways is critical for invasive embryos. The aim of this study was to examine the uterine humoral environment associated with implantation outcome 24 hours before and at the time of embryo transfer of euploid embryos.

[0067] Materials and methods: Infertile patients (n = 48) were recruited with ethics board (IRB) consent before estradiol / progesterone replacement frozen embryo transfer (FET) with euploid blastocysts. Uterine secretions were collected by gentle aspiration (approximately 2-5 microliters) 24 hours before or at the time of FET. Briefly, using a mock transfer protocol typically performed ...

example 2

[0080] Example 2: Minimally Invasive Uterine Aspiration 24 Hours Prior to Embryo Transfer Characterizes the Impaired RIF Uterine Microenvironment and Predicts Reproductive Outcome

[0081] Purpose: Repeat implantation failure (RIF) is particularly challenging to treat, resulting in limited success, even when the endometrium has been adequately prepared and high-grade euploid blastocysts are used for transfer. The aim of this study was to use a multidisciplinary approach to decipher the intricacies of RIF by studying maternal molecular components prior to embryo transfer.

[0082] Materials and methods: Patients were recruited with IRB consent 24 hours prior to programmed frozen embryo transfer (FET) with euploid blastocysts. Uterine secretions were collected by gentle suction (approximately 2-5 microliters) under ultrasound guidance and grouped according to reproductive outcome: euploid FET failure (patients with RIF, ≥3 prior IVF failures) and positive live birth FET (patien...

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Abstract

Provided herein are methods, systems, and kits for improving success rates in assisted reproductive technologies such as in vitro fertilization, frozen embryo transfer, and intrauterine insemination. These methods, systems, and kits rely on levels of protein, metabolite, and microRNA markers determined herein to be linked to uterine toxicity and embryo implantation failure.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 796,695, filed January 25, 2019, entitled "Endometrial Fluid for Predicting Fertility Treatment Success," under 35 U.S.C 119(e) , and claims priority to U.S. Provisional Patent Application No. 62 / 841,008, entitled "Endometrial Fluid for Predicting Fertility Treatment Success," filed April 30, 2019, each of which is incorporated herein by reference . Priority is claimed in each of the above-mentioned published applications, where appropriate. technical field [0003] The present invention relates to the field of fertility treatment. Rather, assessing the uterine microenvironment is used to improve pregnancy success, for example when a fertilized egg implants in a patient's uterus. In addition, manipulation of the uterine microenvironment improves pregnancy chances in both natural and artificial cycles. Background technique [0004] Despit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6888G01N33/50G01N33/68
CPCC12Q1/6888G01N33/68G01N33/50G01N2800/36C12Q2600/178C12Q2600/158G01N33/6842G01N33/689G01N2800/367C12Q1/6876
Inventor M·卡茨-贾菲W·B·斯库克拉夫特
Owner FERTILITY LAB SCI
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