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Rapid polymerized hydrogel material as well as preparation method and application thereof

A hydrogel, fast technology, applied in medical science, bandages, etc., can solve the problems of restricting the development of biological tissue dressings, lack of anti-bacterial infection ability, complex production process, etc. fast healing effect

Active Publication Date: 2021-10-22
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the following types of biological materials are basically used in superficial skin repair: 1. Biological tissue dressings: mainly exist in animal skin and connective tissue, but the lack of sources of this material also limits the development of biological tissue dressings
2. Synthetic polymer dressing: the formed film has a good barrier effect, but has no anti-bacterial infection ability, poor moisturizing performance and other shortcomings
3. Thin-film synthetic dressings: have a certain degree of isolation, but they are more likely to cause pathogens to invade after absorbing and saturating the exudate
However, the production process is complex and requires the use of a large number of toxic reagents for modification
In summary, although there has been a certain breakthrough in the preparation of a material that can quickly polymerize and repair superficial skin, each material still has the disadvantages of complicated operation and numerous processes, so continuous improvement and optimization are still needed

Method used

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  • Rapid polymerized hydrogel material as well as preparation method and application thereof
  • Rapid polymerized hydrogel material as well as preparation method and application thereof
  • Rapid polymerized hydrogel material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take deionized water as solvent, take 10mL of deionized water, add 0.005mol of NaHCO 3 , stir well. Then add 0.01g of sodium carboxymethylcellulose and stir thoroughly; after the solution is completely clarified, add 0.08g of glucose again and stir evenly to obtain solution A; in 10mL of deionized water, add glacial acetic acid to make the concentration of glacial acetic acid reach 0.1mol / L, stir well and then add 0.04g chitosan, stir well to solution B. The two solutions of solution A and B were mixed uniformly at 37°C at a volume ratio of 1:1, and no gel was formed after 10s.

Embodiment 2

[0041] Take deionized water as solvent, take 10mL of deionized water, add 0.005mol of NaHCO 3 , stir well. Then add 0.1g of sodium carboxymethylcellulose, stir well, add 0.08g of glucose again after the solution is completely clarified, and stir evenly to obtain solution A; in 10mL of deionized water, add glacial acetic acid to make the concentration of glacial acetic acid reach 0.1mol / L, stir well and then add 0.04g chitosan, stir well to solution B. The two solutions of solution A and B were mixed uniformly at 37°C at a volume ratio of 1:1. After 10 seconds, the sodium carboxymethylcellulose solution was layered, and the layer was still layered after thorough stirring. The two solutions could not form a gel after mixing.

Embodiment 3

[0043] Take deionized water as solvent, take 10mL of deionized water, add 0.005mol of NaHCO 3 , stir fully; then add 0.05g of sodium carboxymethyl cellulose, and stir fully; after the solution is completely clarified, add 0.08g of glucose again, and stir evenly to obtain solution A; in 10mL deionized water, add glacial acetic acid to make the solution glacial acetic acid When the concentration reaches 0.1mol / L, stir evenly and then add 0.04g chitosan, stir evenly to get solution B. The two solutions of solution A and B were mixed uniformly at 37°C at a volume ratio of 1:1, and a gel was formed after 10 seconds. Such as Figure 1-3 As shown, chitosan has been completely dissolved in glacial acetic acid solution, and there is no layered solution to mix evenly; each component of sodium carboxymethyl cellulose, glucose, and sodium bicarbonate solution has been completely dissolved to form a uniform and stable colloidal solution; Cross-linking occurred after mixing the two soluti...

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Abstract

The invention discloses a rapidly polymerized hydrogel material and a preparation method and an application thereof, the hydrogel is prepared by taking sodium carboxymethyl cellulose, glacial acetic acid, glucose and chitosan as raw materials to rapidly obtain antibacterial and breathable thin-layer hydrogel, and the hydrogel is expected to be used for rapid healing of superficial skin injury. The preparation process is simple, no waste is generated, rapid film forming of the thin-layer hydrogel can be achieved only through simple mixing, compared with related materials in the current market, better physicochemical and biological performance is shown, sodium carboxymethyl cellulose guarantees the drug activity to the maximum extent, chitosan guarantees the antibacterial performance, and glucose is used as a cross-linking point to promote the material to form a gel structure.

Description

technical field [0001] The invention belongs to biological materials, and in particular relates to a rapid polymerization hydrogel material and its preparation method and application. Background technique [0002] As the largest organ of the human body, the skin is the first line of defense between the human body and the outside world. It has functions such as resisting the invasion of external bacteria, maintaining the balance of body fluids and electrolytes, and regulating body temperature. However, in life, the skin will inevitably be damaged due to various reasons, causing damage to the skin structure. [0003] At present, the requirements for superficial skin repair materials are as follows: 1. It can prevent bacterial contamination and infection; injury. At present, the following types of biological materials are basically used in superficial skin repair: 1. Biological tissue dressings: mainly exist in animal skin and connective tissue, but the lack of sources of thi...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08J3/075C08L5/08C08L1/28
CPCA61L26/008A61L26/0061A61L26/009A61L26/0066A61L26/0023C08J3/075A61L2300/232A61L2300/404A61L2300/602C08J2305/08C08J2401/28C08J2301/28C08J2405/08C08L5/08C08L1/286
Inventor 王婷蔡成龙韩旭张译心
Owner SOUTHEAST UNIV
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