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Filler and preparation method of filler

A technology of fillers and preparation steps, which is applied in the field of fillers and filler preparations, can solve the problems of poor tissue repair effect, difficulty in forming delicate and natural shapes, pain, etc., and achieve the effect of simplifying the classification process and improving production efficiency

Active Publication Date: 2022-07-22
红色未来科技(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] On the other hand, after the cross-linked hydrogel is produced, the existing filler production method of making microbeads through a mechanical processing process (such as pulverization) is difficult to adjust the diameter of the microbeads during pulverization, and the surface of the microbeads is uneven or microbead deformation, etc., it is not easy to make microbeads that are as round as a ball and have a smooth surface
[0005] In addition, homogeneous crosslinked hydrogel microbeads, in which the inside and outside of the microbeads are crosslinked at a uniform degree of crosslinking, are difficult to incorporate useful substances due to the narrow space inside the microbeads, and it is difficult to apply sustained release of useful substances. technology
[0006] At the same time, if the size of the hydrogel microbeads is too small, the tissue repair effect will be poor when injected into the body, and will be quickly decomposed by the macrophage function of macrophages, and the microbeads will be absorbed into the dermis or abnormally move into the blood, causing side effects
If the size of the hydrogel microbeads is too large, it will cause pain due to increased pressure during injection, it will be difficult to inject, and it will be difficult to form a delicate and natural shape after injection

Method used

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Embodiment Construction

[0034] Preferred embodiments of the present invention will be described in more detail with reference to the accompanying drawings, but for the sake of brevity, technical parts that are already well known will be omitted or condensed.

[0035] It should be noted that references in this specification to "one" or "an" embodiment of the invention are not necessarily the same embodiment, but refer to at least one.

[0036] In the following embodiments, the use of terms such as first and second is not intended to limit their meanings, but is used to distinguish one technical feature from other technical features.

[0037] In the following examples, unless the context clearly dictates otherwise, singular expressions include plural expressions.

[0038] In the following examples, terms such as 'including' or 'having' refer to the presence of the features or techniques described in the specification

[0039] feature, not an additional possibility that precludes more than one other fe...

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Abstract

A filler and a preparation method of the filler are disclosed. The preparation method of the filler may include a micelle manufacturing step of mixing and stirring a biodegradable polymer solution and oil to produce a polymer micelle; by cross-linking the aforementioned polymer micelles, a microsphere of hydrogel microbeads filled with oil is produced. A bead production step; and a hollow bead production step of removing oil contained in the hydrogel microbeads to produce hollow-shaped microbeads.

Description

technical field [0001] The present invention relates to a filler and a preparation method of the filler. Background technique [0002] Typically, dermal fillers are used for therapeutic or cosmetic purposes. For example, if fillers are injected into the fine wrinkles of the skin, as the volume of the soft tissue expands, it will reduce the skin wrinkles for a cosmetic effect. Regarding this, Korean Registered Patent Publication No. 10-1967153 has disclosed a technique of a filler composition. [0003] One of the constituent materials of fillers, hyaluronic acid, is a biopolymer that exists in the human body and is widely used in medical or cosmetic applications due to its excellent biological adaptability. However, since hyaluronic acid itself is decomposed in the human body within a few hours, its application is limited, so research to increase the persistence of hyaluronic acid in the body by cross-linking has been carried out. In order to increase the duration of hyalu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/24A61L27/18A61L27/20A61L27/22A61L27/52A61L27/54A61L27/58A61L27/60
CPCA61L27/20A61L27/24A61L27/222A61L27/18A61L27/52A61L27/54A61L27/58A61L27/60A61L2430/34A61L2400/06A61F2/0059A61L2300/626A61L2300/402A61L2300/404
Inventor 南中赫崔斗烈金敏秀
Owner 红色未来科技(北京)有限公司
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