Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Filler and preparation method thereof

A filler and a technology for preparation steps, applied in the field of filler and filler preparation, can solve the problems of poor tissue repair effect, difficulty in forming a delicate and natural shape, pain, etc., and achieve the effects of simplifying the classification process and improving production efficiency

Active Publication Date: 2021-10-22
红色未来科技(北京)有限公司
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] On the other hand, after the cross-linked hydrogel is produced, the existing filler production method of making microbeads through a mechanical processing process (such as pulverization) is difficult to adjust the diameter of the microbeads during pulverization, and the surface of the microbeads is uneven or microbead deformation, etc., it is not easy to make microbeads that are as round as a ball and have a smooth surface
[0005] In addition, homogeneous crosslinked hydrogel microbeads, in which the inside and outside of the microbeads are crosslinked at a uniform degree of crosslinking, are difficult to incorporate useful substances due to the narrow space inside the microbeads, and it is difficult to apply sustained release of useful substances. technology
[0006] At the same time, if the size of the hydrogel microbeads is too small, the tissue repair effect will be poor when injected into the body, and will be quickly decomposed by the macrophage function of macrophages, and the microbeads will be absorbed into the dermis or abnormally move into the blood, causing side effects
If the size of the hydrogel microbeads is too large, it will cause pain due to increased pressure during injection, it will be difficult to inject, and it will be difficult to form a delicate and natural shape after injection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Filler and preparation method thereof
  • Filler and preparation method thereof
  • Filler and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] .

[0086] Mix sodium hyaluronate with 1N sodium hydroxide solution to make the concentration of sodium hyaluronate reach 10w / v%, and stir for 3-4 hours to prepare a biodegradable polymer solution. Mix the prepared biodegradable polymer solution with mineral oil, rotate with an impeller at 1000-2000 rpm for 30 minutes to 15 hours, and stir the mixed solution of biodegradable polymer solution and mineral oil at high speed. When mixing the biodegradable polymer solution with mineral oil, the content was set to the values ​​described in Table 1 below. The impeller structure and figure 2 Similarly, an impeller with three steel wires crossing each other at an angle and fixed to the rotating shaft is used.

[0087] After that, a cross-linking agent (butanediol diglycidyl ether) was added to the stirring material, and after stirring at 1000 rpm, the polymer micelles were cross-linked at room temperature for 24 hours. At this time, the content of the crosslinking age...

Embodiment 2

[0090] .

[0091] In addition to setting the content of the cross-linking agent as described in the following table 2, and putting the hydrogel microbeads classified according to the diameter of 50-500 μm into a vacuum oven, and drying them under vacuum at 20mmHg for 1 hour at 60°C , the setting of other matters when preparing hydrogel microbeads is the same as that of Example 1.

[0092] 【Table 2】

[0093] .

Embodiment 3~4

[0094] .

[0095] Except that the number of steel wires of the impeller was set according to the values ​​listed in Table 3, the setting of other matters during the preparation of hydrogel microbeads was the same as in Example 1.

[0096] 【table 3】

[0097] .

[0098] Productivity evaluation of hydrogel microbeads.

[0099] To confirm the productivity of different biodegradable polymer solution to mineral oil volume ratios, the following experiments were performed. In the production process of each Example and Comparative Example, after recovering the hydrogel beads filled with additives, the hydrogel beads were sorted by size using a sieve. When the proportion of beads with a diameter of 50 to 500㎛ in all the produced hydrogel beads exceeds 80%, it is evaluated as excellent in productivity, and when it is less than 80%, it is evaluated as poor in productivity. The results are shown in Table 4 below.

[0100] 【Table 4】

[0101] .

[0102] As show...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention discloses a filler and a preparation method thereof. The preparation method of the filler comprises the following steps: a micelle preparation step of mixing and stirring a biodegradable polymer solution and oil to prepare polymer micelle; a microbead production step of producing hydrogel microbeads filled with oil by crosslinking the polymer micelle; and a hollow microbead production step of removing the oil contained in the hydrogel microbeads to produce hollow microbeads.

Description

technical field [0001] The invention relates to a filler and a preparation method of the filler. Background technique [0002] Typically, dermal fillers are used for therapeutic or cosmetic purposes. For example, if fillers are injected into the fine wrinkles of the skin, the cosmetic effect will be achieved by reducing the skin wrinkles as the soft tissue volume expands. Regarding this, Korean Registered Patent Publication No. 10-1967153 has disclosed a technology of a filler composition. [0003] Hyaluronic acid, one of the constituent materials of fillers, is a biopolymer substance that exists in the human body. Due to its excellent biological adaptability, it is widely used in medical treatment or cosmetics. However, since hyaluronic acid itself is decomposed within a few hours in the human body, its application is limited, so research to increase the persistence of hyaluronic acid in the body through cross-linking has been conducted. If the content of cross-linking a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/18A61L27/20A61L27/22A61L27/52A61L27/54A61L27/58A61L27/60
CPCA61L27/20A61L27/24A61L27/222A61L27/18A61L27/52A61L27/54A61L27/58A61L27/60A61L2430/34A61L2400/06A61F2/0059A61L2300/626A61L2300/402A61L2300/404
Inventor 南中赫崔斗烈金敏秀
Owner 红色未来科技(北京)有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com