A high-purity collagen extraction process

A technology of collagen and extraction process, which is applied in the field of protein extraction, can solve the problems of no virus process verification, collagen cannot be applied to tissue engineering, and no research on the integrity of collagen triple helix structure, so as to achieve the effect of improving purity
CN113563460BActive Publication Date: 2022-03-11浙江崇山生物制品有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
浙江崇山生物制品有限公司
Publication Date
2022-03-11

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Abstract

The invention provides a high-purity collagen extraction process, which belongs to the technical field of protein extraction. The extraction process includes the Achilles tendon pretreatment step and the collagen extraction and purification step. During the implementation process, the reagents in the pretreatment process, as well as the concentration of various reagents, mixing methods and addition sequences are reasonably controlled, and the pretreatment process is obviously improved. The removal efficiency of Achilles tendon fat during the process improves the purity and activity of collagen, and the obtained collagen has a complete triple helix structure, which is safer and can meet the needs of cosmetics, medical devices, and tissue engineering.
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Description

technical field

[0001] The invention belongs to the technical field of protein extraction, and in particular relates to a process for extracting high-purity collagen from Achilles tendon. Background technique

[0002] Collagen is the most abundant type of protein in animals, accounting for more than 30% of the total protein content, and is widely distributed in tissues and organs such as bones, cartilage, tendons, skin, and blood vessels. Among the 28 known collagen types, type I collagen is the most abundant and widely distributed. Because of its good biocompatibility, low immunogenicity, good biomechanical properties, etc., it can be used as a natural biological framework component, and has huge application space in clinical medicine, tissue engineering, medical bioengineering and other fields.

[0003] There are many existing collagen extraction methods, but almost all of them have a problem of removing impurities. Removing lipids by adding organic solvents such as aceto...

Claims

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