21 results about "Calcanean tendon" patented technology

The invention provides an electrically-driven chassis bionic angle module structure imitating cirific muscles and ostrich achilles tendon, which is applied to the technical field of angle module structure design, and a suspension structure comprises an active adjusting mechanism, a force transmission guide mechanism, a damping hydraulic rod, an arc-shaped spring and a detection mechanism; the active adjusting mechanism drives an adjusting lever through a servo motor to change the posture of the suspension structure and adjust the pre-tightening force of an adjusting spring. The force transmission guiding mechanism is composed of a multi-connecting-rod structure, transmits impact loads generated by wheels to a vehicle body and guides the motion trails of the wheels. The arc-shaped spring generates elastic deformation in the movement process of the suspension structure so as to store impact energy; the damping hydraulic rod provides damping energy consumption for the movement of the suspension structure; the detection mechanism is used for detecting the stress change of the suspension structure and providing feedback for active adjustment. Through the synergistic effect of multi-connecting-rod guiding, arc-shaped spring energy storage and hydraulic damping, graded absorption and stable transmission of wheel impact loads are achieved, and therefore the vehicle running stability and the suspension structure response performance are improved.

A rosmarinic acid delivery microneedle patch is characterized in that a filter paper substrate fixed with a microneedle array is subjected to balanced expansion in an alcoholic solution of rosmarinic acid RosA, and after the alcoholic solution is removed, the rosmarinic acid delivery microneedle patch, which is called RosA-MP for short, is obtained. The capability of RosA-MP for inducing polarization of M2 M phi and capturing ROS is evaluated through in-vitro co-culture. A potential mechanism of RoA-MP induced M2 type M phi polarization is analyzed by using a gene sequencing technology. A collagenase I (COLI) solution is injected into the achilles tendon of a rat in situ, and an achilles tendon lesion model is established. Hamp is adopted; the in-vivo immune regulation function, the antioxidant function and the treatment effect on the tendon lesion after RosA-MP treatment are studied in detail by adopting the methods of dyeing, E dyeing, Masson dyeing, immunohistochemical dyeing and the like.

The utility model relates to an achilles tendon suturing device which comprises a supporting assembly, a clamping assembly and an adjusting assembly, the supporting assembly comprises a first supporting piece and a second supporting piece, the clamping assembly comprises a first clamping piece and a second clamping piece, and the first clamping piece and the second clamping piece are located between the first supporting piece and the second supporting piece; the adjusting assembly comprises a first adjusting piece and a second adjusting piece, a fixing mechanism is arranged between the first supporting piece and the second supporting piece, the first adjusting piece and the second adjusting piece are located at the two ends of the fixing mechanism respectively, and the first adjusting piece can drive the first supporting piece and the second supporting piece to move relatively in the axial direction of the fixing mechanism. The second adjusting part can drive the first clamping part and the second clamping part to relatively move in the axial direction of the fixing mechanism, by means of the technical scheme, the achilles tendon and the achilles tendon external structure can be fixed, and therefore the achilles tendon fracture suturing efficiency can be improved, the recovery time of a patient can be shortened, and surgical incisions can be reduced.

The utility model discloses an achilles tendon suturing puncture guide structure based on laser positioning, and particularly relates to the technical field of achilles tendon suturing, which comprises a puncture tube, a micro laser is arranged at the front end in the puncture tube, and the micro laser is detachably connected with the puncture tube. According to the utility model, the movement point of the puncture tube is irradiated by the micro laser and can penetrate through the other puncture hole in the oval forceps, so that the movement point of the positioning puncture outfit can be visually known from the outside, the positioning puncture outfit can accurately penetrate through the achilles tendon, and the situation that the positioning puncture outfit is inclined and other tissues at the achilles tendon are damaged is avoided; damage is reduced, and puncture efficiency is improved.

The invention relates to the technical field of biochemistry and biological materials, in particular to a method for extracting high-activity I-type and III-type collagen from bovine achilles tendon tissues. The method aims at solving the technical problems that in the extraction process, a collagen triple helix active structure is difficult to completely extract, and inactivation and heterologous collagen immunological rejection are easily caused by high temperature. According to the invention, oligopeptide is introduced to protect a triple helix structure and a functional segment of collagen, so that the immunogenicity is reduced. According to the method, the complex enzyme is added, the pretreated bovine achilles tendons are subjected to enzymolysis under the low-temperature condition, and the complete triple-helix structures of the I-type collagen and the III-type collagen are protected. According to the method disclosed by the invention, the stability of the collagen structure is regulated and controlled by utilizing the difference of denaturation temperatures of the type I collagen and the type III collagen and controlling the temperature gradient in the purification stage, so that the collagen with high stability and low immunogenicity is obtained, and the complete triple-helix structure and biological activity are kept; the method can be applied to beauty injection, skin soft tissue filling, tissue repair and the like in the field of medical beauty.

The heel cup comprises a supporting part and a bending part which are integrally arranged, the supporting part corresponds to the position of the calcaneus of the human body, the bending part is arranged on the upper portion of the supporting part, the upper end of the bending part extends towards the direction of the achilles tendon of the human body in the vertical direction, and the bending part is arranged on the upper portion of the supporting part. The upper end of the bent part extends in the transverse direction in the direction away from the heel of the human body so as to form an inclined face facilitating wearing and taking-off, and the hardness of the bent part is smaller than that of the supporting part. The shoe is more convenient to put on and take off, meanwhile, the wearing comfort of the heel part can be greatly improved, the heel part is not prone to deformation or damage due to repeated treading, and the service life of the shoe is prolonged.

The invention provides an application of miR-494-3p in preparation of a medicine for treating and repairing achilles tendon injury, relates to the technical field of biomedicine, and is technically characterized in that the application provides the application of miR-494-3p in preparation of the medicine for treating and repairing achilles tendon injury. The invention also provides an application of the miR-494-3p nanosphere hydrogel sustained-release system prepared from the miR-494-3p in preparation of a medicine for repairing achilles tendon injury, wherein the miR-494-3p nanosphere hydrogel sustained-release system is loaded with the miR-494-3p. According to the present invention, the specific embodiment verifies that the miRNA nanosphere hydrogel delivery system can effectively release the miR-494-3p, and can meet the requirement of tendon injury repair. Research finds that miR-494-3p improves tendon healing and increases the maximum tension strength of tendons by promoting tendon cell proliferation, inhibiting inflammation and apoptosis and enhancing synthesis of extracellular matrixes (especially I-type collagen) at the same time.

The application is suitable for the technical field of collagen materials, and provides a CS-HA nanoparticle crosslinked collagen protein shield and a preparation method thereof.The application proposes that type I collagen protein extracted from bovine Achilles tendon is used as a shield preparation material, and CS-HA nanoparticles are used as a crosslinking agent after being activated by EDCM, so that multiple crosslinking sites can be provided, crosslinking efficiency is increased, and the advantages of no crosslinking agent residue, high biological safety and the like are achieved.In addition, the CS-HA nanoparticles can effectively promote the repair of corneal injury, inhibit bacteria and improve the bioavailability of delivered drugs.On this basis, the added PRAM2 plays pharmacological effects such as anti-inflammatory and antioxidant effects.The application realizes the performance improvement of the traditional collagen protein shield, plays the advantages of the collagen protein shield as a corneal bandage, and has a wide application prospect.

The invention relates to the field of low-immunogenicity medical collagen. A preparation method of the low-immunogenicity collagen comprises the following steps: raw material pretreatment, enzyme treatment, inactivation treatment, separation and purification, and drying. The raw material is one of fresh pigskin, cow leather and bovine achilles tendon; the inactivation treatment refers to treatment with the pH value being 7 or below; the drying is low-temperature drying. The collagen provided by the invention has high purity which is greater than 99%, and has low immunogenicity.

The invention discloses application of carnosic acid in preparation of a medicine for treating traumatic ectopic ossification. The inventor finds that carnosic acid can reduce the overall level of ROS and inhibit a downstream PTEN / PI3K signal channel by researching the influence of carnosic acid on the intracellular ROS level and the downstream signal channel in the inflammation-induced tendon stem cell osteogenic differentiation process, so that the osteogenic differentiation of tendon stem cells is inhibited. Experimental results show that in an in-vivo experiment of burn and achilles tendon cutting ectopic ossification mice, the carnosic acid can relieve oxidative stress and osteogenic differentiation caused by trauma and inhibit ectopic ossification formation. Therefore, a new thought and a theoretical basis are provided for developing a new medicine for treating ectopic ossification, and the formation of traumatic ectopic ossification can be inhibited in a targeted manner by applying the carnosic acid.

This invention relates to the field of medical materials technology, and more particularly to an inner and outer layer filling material for a composite artificial tissue microparticle scaffold and its preparation method. The method includes: first, modifying bovine Achilles tendon type I collagen and chondroitin sulfate with thiolation, then mixing and reacting them with corresponding components to granulate, thus obtaining an inner layer of injectable microparticle gel; then preparing boric acid-modified ε-polylysine, separately preparing a dense moisturizing gel membrane and a gradient porous drainage sponge, bonding the two together at the interface, and drying to obtain the final product. This invention, through the dual cross-linking structure design of the inner layer of injectable microparticle gel and the synergistic construction with the outer double-layer membrane, significantly improves the mechanical strength, degradation rate, matching with new tissue growth, and biocompatibility of the composite material.

The utility model discloses a fixing device for achilles tendon suturing, which relates to the technical field of achilles tendon suturing and comprises a first sliding rail, an arc-shaped support is fixedly connected to the side wall of the first sliding rail, a second sliding rail is fixedly connected to one end of the arc-shaped support, and two lower-layer steel plates are arranged at the upper end of the first sliding rail. Connecting plates are fixedly connected to the two ends of the lower surface of the lower-layer steel plate, fixing assemblies are arranged in the connecting plates, lower teeth are arranged at the upper end of the lower-layer steel plate, a first mounting groove is formed in one end of the upper surface of the lower-layer steel plate, and two second mounting grooves are formed in the inner side wall of the first mounting groove. The clamping connection between the clamping columns and the clamping grooves is removed, after the steel plate moves to the needed position, the clamping columns are directly loosened, the limiting between the lower-layer steel plate and the two sliding rails can be rapidly completed, then the lower-layer steel plate and the upper-layer steel plate are directly connected, the upper-layer steel plate is directly pressed downwards, the clamping blocks are connected with the second mounting grooves in a clamping mode, and the operation efficiency is improved.

The invention discloses a decellularized extracellular matrix modified flexible mesh scaffold for achilles tendon rupture repair and a preparation method thereof, and belongs to the technical field of degradable tissue scaffolds. The stent provided by the invention adopts a double-layer composite structure design, and the outer layer is a PCL / ECM gel mixed electrostatic spinning layer and loads natural growth factors; a degradable PCL hollow support is printed on the inner layer in a fused deposition 3D mode and used for providing mechanical support for a main body. According to the stent, a bioactive layer is constructed, natural slow release of growth factors is achieved, uncontrollability of exogenous addition is avoided, the tendon regeneration induction capacity is remarkably enhanced, the achilles tendon repair capacity is preliminarily verified in a rabbit achilles tendon injury model, an ECM / PCL degradable material is adopted, secondary operation is avoided, and the stent has excellent medical application prospects.

1. The name of the design product: Achilles tendon stretcher. 2. The use of the design product: for stretching Achilles tendon. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1. 5. The left view is shown in other views; the top view is shown in other views.

The present application belongs to the field of material chemistry and biology technology, and particularly relates to a composite film and a preparation method and application thereof. The HOFilms material of the present application uses a mild and simple preparation method to prepare a high-quality, uniformly distributed hydrogen-bonded organic framework film, effectively retaining the biological function of the material; the production process is simple, raw materials are easy to obtain, and the material can be produced in large scale in a factory; the material can be used as a physical barrier or a support to regulate the repair microenvironment at the molecular level, and further form an integrated active Achilles tendon regeneration platform from mechanical support to biological treatment; the HOFilms material has a "wet response" intelligent property: not only can it stably exist in a wet environment in vivo, but also can utilize or respond to moisture in the environment (such as swelling, shrinking, releasing factors) to perform specific functions, thereby interacting with dynamic physiological processes; the HOFilms material itself has an active biological function, that is, improving the inflammatory microenvironment and directly promoting the regeneration of tendon cells, thereby fundamentally overcoming the healing barrier.

The application provides a biomechanically adaptive Achilles tendon support system capable of monitoring the repair state, which comprises a negative Poisson's ratio structure body in a sheet shape with microneedles, which is used for fixedly adhering to the Achilles tendon and covering the gap of the Achilles tendon end. When the Achilles tendon is stretched, the cross-sectional area of the Achilles tendon is increased, and through the design of the structural parameters, the Achilles tendon support system of the application is elongated along the length direction of the Achilles tendon and is circumferentially deformed and expanded with the stretching of the Achilles tendon, so as to be matched with the deformation of the cross-sectional area of the Achilles tendon. The negative Poisson's ratio structure body is a patch structure, which has good adhesion to the Achilles tendon. The Achilles tendon support system is provided with a biosensor, the sensor can sense the deformation response of the Achilles tendon tissue, and the repair state thereof is monitored. The Achilles tendon support system can be self-degraded by introducing degradable materials, and will not remain in the body as a foreign body.

The invention relates to the technical field of biomedical engineering and tissue regeneration, and particularly discloses a functionalized collagen scaffold based on 3D printing and application of the functionalized collagen scaffold in achilles tendon repair and heterotopic ossification prevention. And integrating the CD26 + tendon stem cell exosome which is pretreated by the BMP inhibitor and modified by the collagen binding peptide to form the 3D printing scaffold. According to the invention, the composite scaffold is prepared by integrating a bifunctional strategy of BMP signal inhibition and collagen targeted slow release and combining a 3D printing technology, so that the problems of insufficient regeneration effect and high incidence of heterotopic ossification (HO) in the existing tendon repair technology are obviously solved.

The invention relates to the technical field of biological medicine, in particular to apoptosis vesicles with a mitochondrial adjusting function, a composite material and application of the apoptosis vesicles and the composite material to preparation of medicine for promoting tendon injury repair, the apoptosis vesicles are derived from tendon stem cells, tendon stem cell apoptosis is induced through tendon stem cell apoptosis induction liquid, and the apoptosis vesicles are derived from the tendon stem cells. The apoptosis vesicles can recover macrophage mitochondrial dysfunction under inflammation conditions, reduce active oxygen in cells and mitochondria, recover mitochondrial membrane potential, regulate mitochondrial function homeostasis, inhibit the macrophage from being converted into pro-inflammatory macrophage M1 type, inhibit the apoptosis of the macrophage, inhibit the apoptosis of the macrophage, inhibit the apoptosis of the macrophage, and inhibit the apoptosis of the macrophage. The transformation to the anti-inflammatory macrophage M2 type is promoted. The invention also prepares the apoptosis vesicle composite material derived from the tendon stem cells loaded on the porous gelatin microspheres, and the composite material can inhibit achilles tendon injury induced by type I collagenase and is used for preparing medicines for promoting tendon injury repair.

1. The name of the design product: air pressure ballistic extracorporeal shock wave therapy instrument. 2. The use of the design product: for the auxiliary treatment of periarthritis of shoulder, humeral epicondylitis, Achilles tendonitis and pain. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective view.

The application discloses a medical collagen extraction method and belongs to the technical field of biomedical materials. The extraction steps are as follows: after removing surface foreign matters from a bovine Achilles tendon, the bovine Achilles tendon is cut into particles, washed by a NaCl solution and soaked by a Tris-HCl buffer solution containing EDTA-Na2; the pretreated bovine Achilles tendon tissue is added into a swelling treatment liquid prepared by taking lactic acid and betaine as raw materials to perform soaking, so that swelled bovine Achilles tendon tissue is obtained; the swelled bovine Achilles tendon tissue is subjected to enzymolysis by pepsin, so that a crude collagen extraction liquid is obtained; poly(N-isopropyl acrylamide) is added into the crude collagen extraction liquid to precipitate a collagen-containing precipitate; after resuspension of the precipitate, constant-volume ultrafiltration diafiltration purification is performed, so that a collagen concentrate liquid is obtained, and the medical collagen extraction is completed. The product has the characteristics of high purity, structural integrity and low endotoxin, meets medical-grade safety standards and is suitable for large-scale popularization and use.

This invention relates to the field of medical auxiliary equipment technology, specifically providing an Achilles tendon fixation device and its usage method. The device includes at least one fixation assembly, each comprising two fixing components. Each fixing component has a flexible fixation part and a rigid fixation part. The rigid fixation part includes a first support rod, a first fixing rod, a connecting rod, a second fixing rod, and a second support rod connected sequentially to each other. The first and second support rods are vertically arranged. Both the first and second fixing rods are detachably connected to the flexible fixation part. The ends of the two first support rods in each assembly are detachably connected via a first threaded rod, and the ends of the two second support rods in each assembly are detachably connected via a second threaded rod. The fixation assembly also includes a window that passes through the flexible fixation part and is located between the first and second threaded rods. This invention allows for simple and convenient replacement of the flexible fixation component and provides efficient and accurate tensioning and fixation of the Achilles tendon.