31 results about "Calcanean tendon" patented technology

The invention provides a novel anti-tissue-adhesion material and a preparation method thereof. Used raw materials are from natural polysaccharides and modified natural polysaccharides; the use of micromolecular cross linking agents is avoided; and the excellent biosecurity is realized. A compound prepared from the natural polysaccharides and the modified natural polysaccharides through chemical reaction can be used for the anti-adhesion purpose in positions such as the pelvic cavity, the abdominal cavity, the achilles tendon and nerves. Meanwhile, the hemostatic, antibacterial and healing promotion functions are realized. The anti-adhesion material provided by the invention can be prepared into anti-adhesion sponge, anti-adhesion films and anti-adhesion gel through different process conditions; the surgical operation convenience is high; good clinic application prospects are realized.

The invention discloses a high-purity natural collagenous fiber and a preparation method thereof. The collagenous fiber is characterized in that fresh traceable animal muscle tendon or achilles tendon is used as a raw material, and is subjected to pre-treatment, water soaking, supercritical carbon dioxide fluid degreasing, alkali leaching, first enzyme treatment, acid leaching, secondary enzyme treatment, salting out, centrifugal purification and other processes to obtain the high-purity natural collagenous fiber. The high-purity natural collagenous fiber prepared by the method is aggregation of natural collagen molecules, has the quarternary structure of collagen and the intrinsic bioactivity of collagen, and has more spatial structure features of collagen in natural tissues, so that the natural tissue structure can be further simulated. Compared with a collagen material, the natural collagenous fiber prepared by the method has the advantages of excellent mechanical performance, thermal stability and biodegradation performance, and the structure of the natural collagenous fiber is relatively stable and easy to store; and characteristic group expression of cells can be activated, and normal characteristic expression of cells can be maintained, so that adhesion, growth and proliferation of cells can be benefited. The natural collagenous fiber can be used for preparing hemostatic materials, tissue engineering scaffold materials, medical plastic and cosmetic materials and the like.

The invention provides a collagen implant and a preparation method thereof, and relates to the field of beauty. The collagen implant comprises the following components: collagen fibers and a phosphate buffer solution with the pH value of 7. The invention also provides a preparation method of the collagen fibers, the collagen molecules obtained by adopting the method provided by the invention have a fiber structure with a clear shape after self-aggregation, each fiber is completely exposed and mutually staggered to form a fiber web, and meanwhile, the periodic cross grain D band of the collagen fiber can be clearly observed, and a better fiber form can be formed, and the molecular regularity is higher; the collagen fibers are uniform in thickness and have better elastic strength; besides, the collagen implant is the first material source which is prepared from achilles tendon collagen and can be safely traced to the source through a block chain in the whole world, a virus inactivation pretreatment technology and a precise enzyme digestion telopeptide removal technology are adopted, potential allergy risks can be completely removed, and the prepared implant has a more natural shaping filling effect and a long in-vivo degradation period.

The invention relates to a technology of preparing acid-soluble bovine tendo calcaneus collagen by a freeze thawing-ultrasonic method. The technology comprises the specific steps of: (1) bovine tendo calcaneus pretreatment: removing impurities from fresh bovine tendo calcaneus, soaking with normal saline, washing with pure water, freezing, slicing and airing, (2) swelling: putting and soaking aired bovine tendo calcaneus slices in an acetic acid solution for swelling, (3) beating: adding pure water into a swelled bovine tendo calcaneus suspension, performing mechanical beating to obtain crude slurry, (4) freeze thawing-ultrasonic: freezing the beaten bovine tendo calcaneus crude slurry, then performing ultrasonic treatment, repeating the freeze thawing-ultrasonic process to obtain a crude collagen extract, and (5) purification: performing filtering, centrifuging, salt precipitation, dialysis and freeze drying on the crude collagen extract to obtain the collagen product. The extraction method of the bovine tendo calcaneus collagen is simple and convenient and low in cost, the extraction rate of the collagen is increased without using enzyme, the purity of the obtained collagen is high, and a natural structure of the collagen is reserved. The prepared collagen can be applied to industries of medicine, cosmetics and the like.

The invention relates to the technical field of medical devices, in particular to a device for fixing achilles tendon skin. The device comprises a flexible fixing part and a rigid fixing part, whereinthe rigid fixing part is detachably mounted on the flexible fixing part. The device has a better fixing effect and low possibility of causing pressure sore on the achilles tendon skin of a patient, effectively shortens recovery time of the patient and can guarantee the fixing effect; a bag body containing analgesics is relatively convenient to replace; medical care personnel can conveniently nurse a wound in the achilles tendon skin of the patient; the device is quicker and more convenient to use; an adverse phenomenon of accidental breakage of a steel wire when two ends of the steel wire arearticulated to form a knotting articulated column can be effectively avoided; therefore, a trouble of secondary fixing of the wound in the achilles tendon skin of the patient is avoided; and particularly importantly, the patient can be prevented from a pain of the secondary fixing. The invention further discloses a use method of the device for fixing the achilles tendon skin. The recovery time ofthe patient can be effectively shortened.

The invention discloses a simple and feasible achilles-tendon-type smashing and grease removing method. Achilles-tendon-type powder obtained by smashing through the method is suitable for extraction of collagen proteins, and the collagen proteins keep complete triple-helical structures and can be used for preparing collagen protein sponges and collagen protein related products. The method comprises the main steps that fascias, muscles and fat of animal achilles tendons rich in the collagen proteins are mechanically removed, and then the animal achilles tendons are rinsed through water or a sodium chloride solution and frozen; the frozen and hardened animal achilles tendons are taken out, the residual fascias on the surfaces of the achilles tendons are scraped through a blade, and the achilles tendons are cut into slices through a slicer; the achilles-tendon-type slices are each rolled into a strip shape, and the strip-shaped achilles-tendon-type slices are frozen, hardened and then cutinto slices; the achilles-tendon-type slices are placed into a sodium chloride solution with certain concentration and smashed through a smashing machine or a grinding machine, and an achilles-tendon-type suspension is obtained; the achilles-tendon-type suspension is centrifuged, a salt solution is discarded, residues are washed through water, centrifuging is conducted, and the smashed achilles-tendon-type powder is obtained. The smashing method provided by the invention is simple and easy to implement, energy and electricity are saved, the production efficiency is high, and the smashing method is suitable for industrialized production.

The present invention relates to methods of in vitro preparation of a parental cell bank (PCB) from foetal tissue consisting of foetal epiphyseal tissue, foetal Achilles tendon tissue and foetal skin tissue, using a rapid mechanical primary cell culture selection of cell type to be used in methods for wound and tissue repair.

The invention discloses a biomarker related to tendon injury. The relation between GPRC5C and tendon injury is researched for the first time, it is found that after a tendon injury model mouse is treated with a non-steroidal anti-inflammatory drug, the expression quantity of GPRC5C in achilles tendon is increased, and it is prompted that GPRC5C can be used for predicting the prognosis of a tendon injury patient using the non-steroidal anti-inflammatory drug. Meanwhile, the correlation between GPRC5C and tendon injury is verified in a GEO data set. The invention also discloses a method for screening candidate drugs for preventing or treating tendon injury.

The invention discloses a novel collagen mask and a preparation method thereof, and relates to the technical field of skin care masks. The novel collagen mask comprises collagen, fats and amino acids,wherein the collagen is obtained by extracting bovine achilles tendons with citric acid. According to the preparation method, the collagen is extracted from the bovine achilles tendons by adopting citric acid, acetic acid is replaced by citric acid to prepare the collagen, the safety is higher, less wastewater is generated in the production process, and additives such as acetic acid and pepsase which may cause damages to the skin do not need to be treated by an additional process. The bovine achilles tendons are used as raw materials, and thereby the collagen is relatively high in purity andrelatively good in quality. Any substances harmful to the skin and the human body are not added. Components are controllable, and the safety performance is better. A process route is greatly shortened, freeze-drying is not needed, the process is simpler and more effective, the equipment investment is less, the cost is lower, and the large-scale industrial production is easier to realize.

The invention provides a preparation method and application of microneedle loaded with nano-motor driven exosome for treating enthesiopathy, which comprises the following steps: firstly, extracting a tendon stem cell exosome from achilles tendon, then in-situ polymerizing and wrapping the exosome through 2-methacryloyloxyethyl phosphorylcholine, and grafting L-arginine to obtain the nano-motor driven exosome; and mixing the nano-motor driven exosome with methylacrylic acid acylated gelatin and polyvinyl alcohol, adding the mixture into a microneedle template, finally preparing the microneedle loaded with the nano-motor driven exosome, and the microneedle is applied to preparation of a medicine for treating enthesiopathy. The microneedle loaded with the nano-motor driven exosome take nitric oxide gas generated by reaction as driving force of the exosome, the exosome retained in the epidermal layer in the microneedle is delivered to the damaged tendon part by combining the property that the nano-motor attaches to the damaged part with the reduced pH value, and by combining the anti-inflammatory effect of the nitric oxide gas, the treatment effect of the enthesiopathy is effectively improved.

The invention relates to an autologous and homogeneous composition containing adipose-derived mesenchymal stem cells for improving or treating tendon or ligament diseases, a preparation method of thecomposition, and a treatment method of the tendon or ligament diseases. In particular, the adipose-derived mesenchymal stem cells are independently administrated or are administrated in combination with hydrogel; when the adipose-derived mesenchymal stem cells disclosed by the invention are administrated to achilles tendon diseases such as patellar tendon diseases, external epicondylitis, internalepicondylitis, plantar fasciitis, spinner muscle group diseases, tendon sheath synovitis, tendon degeneration, tendon inflammation, tenosynovitis, tendon injury, tendon relaxation and the like, and the ligament diseases such as cruciate ligament injury, ankle ligament injury, collateral ligament injury and the like, the collagen, extracellular matrix (ECM) protein, and various growth factors aresecreted, so that an effect of ameliorating or treating tendon or ligament diseases is exhibited.

The invention provides an achilles tendon repair patch and a preparation method thereof.The achilles tendon repair patch comprises a flaky SIS matrix, tendon stem cells are planted on the SIS matrix, the achilles tendon repair patch takes the flaky SIS matrix as a biological scaffold and the tendon stem cells as seed cells, has good biocompatibility and strong tendon differentiation capacity, and can be used for repairing achilles tendons. The sheet-shaped SIS matrix can wrap the achilles tendon broken end during tendon repair, so that adhesion between surrounding soft tissues and the achilles tendon broken end is isolated, meanwhile, the tendon stem cells carried by the sheet-shaped SIS matrix are accurately attached to the broken end, a good cell microenvironment is provided for proliferation and migration of the tendon stem cells, and a good achilles tendon repair effect is achieved.

Systems and methods for treating fibrous masses associated with conditions such as Morton neuroma, stump neuroma, plantar fibroma, plantar fibromatosis, plantar fascitis, plantar fasciae disease, and Achilles tendinopathy. In accordance with embodiments herein, an exemplary method may include transmitting electromagnetic energy to such a fiber mass in a non-surgical manner by various methods.

The invention provides high-toughness hydrogel based on PHEAA as well as a preparation method and application of the high-toughness hydrogel, and belongs to the technical field of high polymer materials. The structure of the hydrogel is shown as a formula I shown in the specification, wherein x is 100-300; y is 20 to 50; and z is 50 to 300. According to the invention, N-(2-hydroxyethyl) acrylamide (HEAA) and maleic anhydride are copolymerized to obtain the hydrogel with a uniform network structure, and the hydrogel has very high fracture toughness and good biocompatibility. Because of the excellent mechanical property and biocompatibility, the hydrogel can overcome the defects of existing repair materials for tissue such as cartilage and achilles tendon, a tissue repair material with more excellent performance is prepared, and the hydrogel is expected to be widely applied to the aspects of artificial cartilage, artificial achilles tendon and the like and has a good application prospect.

The invention relates to a portable athlete Achilles tendon massage platform and method. The platform comprises name input equipment, used for receiving the name of a to-be-recuperated athlete inputted by a worker; content searching equipment, used for calling out an X-ray Achilles tendon image matched with the name of the athlete in an athlete database based on the received name; wireless communication equipment, used for establishing a wireless communication link connection between the wireless communication equipment and a far-end athlete recuperation server, and calling out an X-ray Achilles tendon image matched with the name provided by the content search equipment from an athlete database stored in an athlete recuperation server according to the name provided by the content search equipment, and returning the X-ray Achilles tendon image to the content search equipment. The portable athlete Achilles tendon massage platform and method are flexible, convenient to use and stable in operation. Since different massage gears can be adaptively selected for the athletes with Achilles tendons of different lengths, the recuperation requirements of the different athletes can be met.

The invention discloses a combined external fixation support for minimally invasive treatment of achilles-tendon-skin multi-section dividing, and relates to the external fixation support, in particular to an external fixation support for minimally invasive anastomosis treatment of the achilles-tendon-skin-multi-section-dividing divided end. As an existing fixing support has the defects that a secondary injury is easy to cause, a wound cannot be healed in a vitro anastomosis manner, minimally invasive operation cannot be used, and using is inconvenient, the external fixation support which is capable of avoiding a secondary achilles-tendon-divided-end pulling cracking injury, healing a wound in a vitro anastomosis manner, achieving minimally invasive operation, simple and easy to achieve isprovided. According to the combined external fixation support for minimally invasive treatment of achilles-tendon-skin multi-section dividing, a first part is a flat-threaded-rod adjustable hook clampcombination and used for external fixation of treatment of an achilles-tendon distal-end wound, a second part is an adjustable joint-linking-rod single hook combination and used for external fixationof treatment of an achilles-tendon proximal wound, and the flat-threaded-rod adjustable hook clamp combination is connected with the adjustable joint-linking-rod single hook combination through a linking-rod clamping block combination. The external fixation support is mainly applied to external fixation of an achilles-tendon-skin-multi-section-dividing minimally invasive surgery.

The invention discloses an antigen-free collagen aggregate and a preparation method thereof. The highly purified antigen-free collagen aggregate is prepared by processing the achilles tendon of a mammal. The preparation method of the antigen-free collagen aggregate has the characteristics of wide raw material source, low cost, simple process and the like. The antigen-free collagen aggregate not only retains the biological activity of collagen, but also has higher mechanical strength, and can be widely applied to surgical hemostatic materials, dressings and other biomedical materials.

A tendo calcaneus suturing instrument, comprising: a first support and a second support that are of a U-shaped structure, a distance adjustment device, a first guide sleeve, a second guide sleeve, a first positioning tube, a second positioning tube and a tendo sheath cutter. An outer arm and an inner arm of the first support, and an outer arm and an inner arm of the second support are respectively provided with a first positioning hole, a first guide hole, a second positioning hole and a second guide hole; and the first guide sleeve / the second guide sleeve is fixed by means of the first positioning hole / the second positioning hole and is matched with the first guide hole / the second guide hole. The first positioning tube / the second positioning tube provided with a through hole is arranged in the first guide sleeve / the second positioning sleeve or the tendo sheath cutter is arranged in the first guide sleeve and / or the second guide sleeve in a matching manner. The tendo calcaneus suturing instrument can simplify the surgical procedure, improve the surgical effect and relieve pains of a patient.

The invention relates to the technical field of medical devices, in particular to a device for fixing achilles tendon skin. The device comprises a flexible fixing part and a rigid fixing part, whereinthe rigid fixing part is detachably mounted on the flexible fixing part. The device has a better fixing effect and low possibility of causing pressure sore on the achilles tendon skin of a patient, effectively shortens recovery time of the patient and can guarantee the fixing effect; a bag body containing analgesics is relatively convenient to replace; medical care personnel can conveniently nurse a wound in the achilles tendon skin of the patient; the device is quicker and more convenient to use; an adverse phenomenon of accidental breakage of a steel wire when two ends of the steel wire arearticulated to form a knotting articulated column can be effectively avoided; therefore, a trouble of secondary fixing of the wound in the achilles tendon skin of the patient is avoided; and particularly importantly, the patient can be prevented from a pain of the secondary fixing. The invention further discloses a use method of the device for fixing the achilles tendon skin. The recovery time ofthe patient can be effectively shortened.

The present invention relates to methods of in vitro preparation of a parental cell bank (PCB) from foetal tissue consisting of foetal epiphyseal tissue, foetal Achilles tendon tissue and foetal skin tissue, using a rapid mechanical primary cell culture selection of cell type to be used in methods for wound and tissue repair.

The invention discloses an extraction method of bovine tendo calcaneus collagen, and belongs to the technical field of biomedical materials, bovine tendo calcaneus pretreatment: soaking and unfreezing Y-shaped bovine tendo calcaneus at room temperature, cleaning the Y-shaped bovine tendo calcaneus with purified water, and soaking the cleaned Y-shaped bovine tendo calcaneus in a refrigerator at 4 DEG C for 24 hours; the method comprises the following steps: gently scraping and removing fascia on the surface of the bovine achilles tendon by using a scalpel, and performing pretreatment: continuing to soak the bovine achilles tendon without fascia in a refrigerator at 4 DEG C for 24 hours, freezing the bovine achilles tendon in a refrigerator at minus 20 DEG C, then slicing the frozen and hard bovine achilles tendon by using a slicing machine, weighing, and finally continuing to soak the bovine achilles tendon slices in the refrigerator at 4 DEG C for 48 hours. According to the method, the collagen is extracted mainly by combining acetic acid and pepsase, the collagen can only be degraded by collagenase, and other proteases cannot cut off collagen peptide chains, so that the pepsase can only cut off terminal peptides of the collagen and cannot cut off the peptide chains of the collagen; therefore, the finally extracted collagen can retain the complete triple helix structure.

The invention relates to the technical field of medical materials, and particularly discloses a soft tissue repair stent and a preparation method thereof. The soft tissue repair stent is formed by weaving medical fibers and is of a net structure, the porosity is 12%-50%, the weight per unit area is 100 g / m < 2 >-300 g / m < 2 >, the thickness is 0.5-3 mm, and the deformation rate under the tensile strength of 16 N / cm is smaller than or equal to 20%. The soft tissue repair stent provided by the invention is small in deformation rate, excellent in mechanical property, moderate in thickness, not easy to creep and tear in the use process, and appropriate in stiffness, better conforms to the structural characteristics of joint soft tissues, and can be widely applied to repair of joint soft tissues such as rotator cuff, patella, achilles tendon, biceps tendon or quadriceps tendon and the like.

The invention discloses a minimally invasive treatment auxiliary device for occlusive achilles tendon rupture and a use method of the device. The technical solution key point of the minimally invasivetreatment auxiliary device for the occlusive achilles tendon rupture includes a puncture needle and a hand-held part; one end of the puncture needle is fixedly connected to the hand-held part, the puncture needle and the hand-held part both have tubular structures, the puncture needle and the hand-held part are coaxial, and the diameter of the hand-held part is larger than the diameter of the puncture needle. The device achieves the effects of a simple structure, convenient use, low production and use costs, and less side damage and complications caused by surgery.

The invention discloses an anastomat for achilles tendon. According to the technical scheme, two handle parts are hinged to a positioning shaft; connecting shafts are arranged on the two clamping parts; the connecting shafts are rotatably connected with the end part, positioned between the pair of aiming arms, of the handle parts; a first driving wheel and a second driving wheel are arranged on the positioning shaft; the first driving wheel and the second driving wheel are coaxially arranged on the positioning shaft and are fixed relative to the positioning shaft; a first driven wheel and a second driven wheel which are in mutual transmission with the first driving wheel and the second driving wheel are respectively arranged on the two connecting shafts; through mutual transmission betweenthe first driving wheel and the first driven wheel and between the second driving wheel and the second driven wheel, the included angle between the straight line where the clamping part is located and the straight line where the sighting arm is located is always consistent, the clamp holes extend in the length direction of the clamping parts, the length of openings of the clamp holes is larger than that of the threading holes, and the problems that in the prior art, harm to the body of a patient is large, and threading is inconvenient are solved.

The invention relates to an achilles tendon suture positioner. The achilles tendon suture positioner comprises a frame which is integrally in a U shape, and a positioning device installed in the frame. The frame consists of a first installation strip, a second installation strip parallel to the first installation strip, and a connecting strip fixedly connected between the first installation stripand the second installation strip; and an installation rod is arranged between the first installation strip and the second installation strip. The positioning device consists of a first clamp fixedlyconnected to the installation rod, a second clamp arranged on the installation rod, and a gasket located between the first clamp and the second clamp; and the second clamp can move on the installationrod in the direction away from the first clamp or close to the first clamp. The achilles tendon suture positioner has the effects of being capable of accurately positioning during suture, and realizing more precise positioning.

The invention provides a collagen aggregate scaffold material and a preparation method thereof, and relates to the technical field of biomedical materials. The method comprises the following steps: (A) soaking collagen aggregates extracted from bovine achilles tendons in a medium; (B) transferring the fully soaked collagen aggregate and medium into a vacuum homogenizer to prepare a collagen aggregate dispersion liquid; (C) transferring the collagen aggregate dispersion liquid into a screen or a receiving container, uniformly shaking, and naturally air-drying; (D) immersing the naturally air-dried transparent material into purified water to absorb water and swell, then pre-freezing at a certain freezing temperature and then freeze-drying to obtain a material with a certain interlayer spacing or pore structure; (E) preparing a stent material with certain tensile strength and flexibility by adopting a cross-linking agent under a certain cross-linking condition; and (F) fully cleaning the scaffold material, and then pre-freezing and freeze-drying at a certain freezing temperature to obtain the collagen aggregate scaffold material.

The invention discloses a three-dimensional achilles tendon minimally invasive suturing auxiliary apparatus. The apparatus comprises a palm part, wherein a first auxiliary claw is formed on one side of the top of the palm part, a second auxiliary claw is formed on one side, away from the first auxiliary claw, of the top of the palm part, a first puncture needle is inserted into a first puncture groove, a second puncture needle is inserted into a second puncture groove, a first ball head is installed on the upper part of the inner wall of a third puncture groove, a first eccentric hole is formed in the bottom of the third puncture groove, a second ball head is installed on the upper part of the inner wall of a fourth puncture groove, a second eccentric hole is formed in the bottom of the fourth puncture groove, and a holding through hole is formed in the rear side of the outer wall of a handle. According to the apparatus, an angle and direction of a puncture channel can be adjusted, a three-dimensional suture routing structure is formed, and therefore the anti-cutting capacity is higher; the puncture needles adopt the eccentric holes corresponding to suture needles, the deflection is performed during puncture, a back-penetrating position of a suture is adjusted, a three-dimensional structure on the side face is formed again, and therefore the three-dimensional intersection is formed; and the holding through hole of a forceps is formed in the handle, so that the operation is convenient.