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A kind of dispersible liquid agent of flufenuron with high stability

A technology of dispersion liquid and flufenoxuron, applied in the field of pesticides, can solve the problems of toxic and harmful organic solvents, existence of safety, environmental protection, long-term storage physical stability of water suspension agent, etc. Stability-enhancing effect

Active Publication Date: 2022-06-07
鹤壁全丰生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Relevant technical workers have been successful in researching flufenuron water suspension, but the long-term storage physical stability of water suspension has not been solved
Commercially available products also have emulsifiable concentrate formulations, but the composition of emulsifiable concentrate contains a large amount of volatile, toxic and harmful organic solvents, so there are safety and environmental protection problems

Method used

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  • A kind of dispersible liquid agent of flufenuron with high stability
  • A kind of dispersible liquid agent of flufenuron with high stability
  • A kind of dispersible liquid agent of flufenuron with high stability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1, the solubility of fiproclamide in different solvents

[0044] Due to the extremely small solubility of fiproclamide in water, in organic solvents (25 °C, g / L): acetone 73.8, xylene 6, dichloromethane 18.8, n-hexane 0.11, cyclohexane 95, trichloromethane 18.8, methanol 3.5 (Liu Changling, Yang Jichun, Modern Pesticide Manual).

[0045] Considering the practical problems in the preparation of pesticide preparations, the necessary screening of the fipronil solvent system is carried out. According to the "GB / T 19137-2003 Pesticide Low Temperature Stability Determination Method", the solubility investigation method is to leave it at 0 °C for 7 days to investigate whether the original drug is precipitated, and if it is precipitated, it is unqualified.

[0046] Unless otherwise specified, the amount of fiproclamide is 5%, and tests involving multiple solvents are supplemented by 100% according to the same amount.

[0047] Table 1 Solubilizide solubility in different sol...

Embodiment 2

[0050] Example 2, the stability of heat storage of fiproclamide in different solvent systems

[0051]According to the "GB / T 19136-2003 Pesticide Thermal Storage Stability Determination Method", the method for investigating the thermal storage stability of fipropyridine in different solvent systems is to detect the fipropyridine content after 14 days of hot storage at 54 °C and compare it with the sample at room temperature to calculate the heat storage decomposition rate.

[0052] Table 2 The rate of heat storage decomposition of fiproclamide in different solvents

[0053] Solvent composition Decomposition rate of hot storage Fiproclamide original drug (control) 0.96％ DMSO 11.29％ DMF 6.90％ NMP 6.13％ DMSO + cyclohexanone 5.06％ DMSO+DMF 9.2％ DMSO + glycol + cyclohexanone 4.67％ NMP + cyclohexanone 5.16％ NMP + ethylene glycol 5.05％ NMP + glycol + cyclohexanone 4.03％

[0054] It can be seen from the data in Table 2 that fi...

Embodiment 3

[0055] Example 3, the type of additive (nonionic surfactant) screening

[0056] The type and amount of additives mainly affect the dilution stability and dispersion stability of the dispersion liquid diluted with water, the present embodiment mainly investigates the dispersion stability of the dispersion liquid. The evaluation of dispersion performance mainly refers to "Determination of Dispersion Stability of CIPAC MT180". The content is briefly described as "the dispersion is prepared according to the prescribed concentration, placed in two-scale emulsification tubes, standing upright for a period of time, and then inverting the emulsification tube several times to observe the dispersion of the dispersion after initial, placed and re-dispersed." 1. Initial dispersion requires complete dispersion; 2. The dispersibility (after 30min) after a certain time requires ≤5mL; 3. The amount of re-dispersion (after 24h) precipitation is required to be ≤ 1mL. The measurement results are met...

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Abstract

The invention discloses a highly stable dispersible liquid agent of flubendron. The dispersible liquid agent of described flubenzuron is made up of flubenzuron, ethylene glycol, cyclohexanone, N-methylpyrrolidone and auxiliary agent; auxiliary agent is agricultural milk 500#, agricultural milk 1061# and maleic acid A compound of sodium diisooctyl sulfonate; the mass percentage composition of the dispersible liquid is as follows: flubenzuron 2-10%; ethylene glycol 5-20%; cyclohexanone 15-40%; Base pyrrolidone 30 ~ 55%; the balance of additives. The dispersible liquid preparation of fiflubenzuron provided by the present invention has significantly improved heat storage stability, meeting the general requirement of "liquid preparation" in "GB / T 19136-2003 Pesticide Heat Storage Stability Determination Method" and stored at 54°C for 14 days The decomposition rate is lower than 5%, and the water dispersion speed is fast; the dilution stability and dispersion stability are both qualified. In addition, the solvents and emulsifiers used are cheap and easy to obtain, and are safe and environmentally friendly.

Description

Technical field [0001] The present invention relates to a highly stable fipronil dispersible liquid agent, belonging to the field of pesticide technology. Background [0002] Compounds that are active ingredients in pesticides are often not directly used in crops and need to be processed into certain preparations and then used in the field. The pesticide preparations being processed should not cause damage to the crop, while maintaining stability for a relatively long time before use and being compatible with the equipment on which the drug is administered. Pesticide preparations can be divided into solid dosage forms and liquid dosage forms, and can be divided into water-soluble dosage forms and water-insoluble dosage forms according to the physical and chemical properties of the original drug. Most pesticide components are not or are not easily soluble in water. Such dosage forms are usually processed into single-phase dosage forms such as wettable powders, dry suspensions, emu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N47/34A01N25/04A01N25/30A01P7/02A01P7/04
CPCA01N47/34A01N25/04A01N25/30Y02A50/30
Inventor 刘德仓李好海李雪晨张海龙杨天军赵康陈罗安郭海沙薛孟刚
Owner 鹤壁全丰生物科技有限公司
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