The invention discloses high weatherability composite modified asphalt for a high-speed railway asphalt concrete waterproof sealing layer. The high weatherability composite modified asphalt is prepared from the following components in percentage by weight: 70% to 79.8% of matrix asphalt, 15% to 20% of a modified composite, 5% to 10% of a component modifier, and 0.2 to 0.4% of a crosslinking agent,wherein the modified composite comprises a styrene-butadiene-styrol copolymer, that is, SBS copolymer, regenerated colloidal particles, and a mixture of an anti-aging agent and an interface enhancingagent. According to the high weatherability composite modified asphalt for the high-speed railway asphalt concrete waterproof sealing layer, (1) the composite modifier prepared by using the SBS copolymer, the regenerated colloidal particles, the anti-aging agent, and the interface enhancing agent can comprehensively improve stability, aging, and weatherability of the matrix asphalt, waste tires are fully utilized, and the cost is lowered, so that a modified asphalt cementing agent is more suitable for the high-speed railway waterproof sealing layer; and (2) according to the method, the composite modifiers are firstly prepared and then granulated, the interface enhancing agent is beneficial to the association between a modifier and the matrix asphalt, micro-nano dispersion of modifier molecules can be realized, the use amount of rubber is increased, and tire pollution is reduced.