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Wireless capsule sensing device and method for gastrointestinal tract pH value detection

A sensing device and technology of gastrointestinal tract, applied in the field of electrochemical detection, can solve difficult problems such as pH and detection of gastrointestinal tract

Active Publication Date: 2021-11-09
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of this, the embodiment of the present application provides a wireless capsule sensing device and method for detecting the pH value of the gastrointestinal tract to solve the problem that it is difficult to detect the pH of the gastrointestinal tract in a clinical non-anesthesia state

Method used

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  • Wireless capsule sensing device and method for gastrointestinal tract pH value detection
  • Wireless capsule sensing device and method for gastrointestinal tract pH value detection
  • Wireless capsule sensing device and method for gastrointestinal tract pH value detection

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Experimental program
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Embodiment

[0100] S1, drawing linear fitting curve of the pH sensor 3:

[0101] Figure 9 with Figure 10 Respectively, showed an open circuit voltage of the standard solution and the pH sensor 3 successively incrementally decreasing pH in the - time response curves. Can be seen from the figure, in both cases sensors exhibited good gradient, adjacent electrical potential in the pH buffer solution is substantially the same in response to the difference, and the open circuit voltage of 60 consecutive seconds - time detection, pH sensor 3 in response to the potential remains stable, the maximum potential drift 0.93mV. Figure 11 Shows a multi-chip pH sensor 3 (N = 5) of a linear fitting curve, obtained by calculating the pH sensitivity of the sensor response of about 3 -74.37mV / pH, goodness of fit (R 2 ) Is ~ 0.9992, suggesting that a pH sensor having a sensitivity higher than conventional, and has a good linearity and repeatability. From the figure we can change linearly in response to the pot...

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Abstract

The invention discloses a wireless capsule sensing device and a method for gastrointestinal tract pH value detection. The device comprises an ingestion type capsule, wherein the ingestion type capsule comprises a capsule structure, a capsule detection circuit and a pH sensor; the pH sensor is used for chemically reacting with hydrogen ions for detecting the gastrointestinal tract environment and outputting a response voltage capable of reflecting the pH value; the capsule detection circuit is electrically connected with the pH sensor and is used for reading the response voltage and converting the response voltage into a digital signal; the capsule structure comprises a sensor chamber for mounting the pH sensor and a circuit chamber for mounting the capsule detection circuit, and the sensor chamber is provided with a grid for liquid to pass through; and the in-vitro receiving end is wirelessly connected with the capsule detection circuit and is used for receiving the digital signal. The problem that the pH value of the gastrointestinal tract is difficult to detect in a clinical non-anesthesia state is solved, and the device has the advantages of convenience, real-time, ingestion type and non-invasive sensing detection.

Description

Technical field [0001] The present application relates to electrochemical detection technology, and particularly relates to a radio apparatus and method for sensing capsule of the gastrointestinal tract for the pH detection. Background technique [0002] The pH of the gastrointestinal tract is a very important physiological indices, many gastrointestinal diseases may involve changes in pH, such as gastric ulcer, duodenal ulcer, dyspepsia, gastroesophageal reflux disease (gastroesophageal reflux, of GERD), Crohn's colitis, ulcerative colitis (inflammatory bowel disease, IBD) and the like. Thus, in clinical practice, it is often necessary for the pH of the gastrointestinal tract in patients with repeated testing. Currently, the line intubation pH probes into the gastrointestinal tract is a common means of clinical testing of its pH. If necessary, the need digestive tract endoscopy biopsy sampling, in vitro assays to pH. Such testing process often requires the patient an anesthetic,...

Claims

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Application Information

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IPC IPC(8): A61B5/145A61B5/07A61B5/00H05K1/14H05K1/18
CPCA61B5/14539A61B5/073A61B5/6861H05K1/147H05K1/18A61B2503/42A61B2503/40
Inventor 刘清君程晨吴越卢妍利张芬妮安子建
Owner ZHEJIANG UNIV
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