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Detection method of strong loquat syrup

A powerful loquat extract and detection method technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of poor controllability and poor specificity

Active Publication Date: 2021-11-12
JIANGXI UNIVERSE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the current drug quality standards, there are only chemical reaction identification of alkaloids and flavonoids, which has poor specificity, weak controllability, and no content determination items
At present, there are only reports on the determination of morphine, codeine or papaverine in poppy shells in Qiangli loquat dew by HPLC or gas chromatography.

Method used

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  • Detection method of strong loquat syrup
  • Detection method of strong loquat syrup

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A detection method of strong loquat extract.

[0053] Among them, the detection methods of Qiangli Loquat Lotion include:

[0054] 1) Establishment of standard detection method for Qiangli Loquat Lotion

[0055] 1) Take 10 copies of the standard Qiangli Loquat Lotion product, add diluent to it for dilution, set the volume to 5.5 times the volume of the original product, then heat it up to 50°C, keep it warm for 1 hour, and set aside;

[0056] 2) Filter the above-prepared solution with a microporous molecular membrane, collect the filtrate, add 35 parts of diluent to the filter residue, heat it up to 35°C, keep it warm for 30 minutes, and then filter again to obtain the filtrate a and the filter residue. Add 43 parts of diluent to the filter residue again, raise the temperature to 45°C, keep the temperature for 45 minutes, and then filter to obtain filtrate b and filter residue, mix the filtrate, filtrate a and filtrate b evenly, and set aside;

[0057] 3) Put the comb...

Embodiment 2

[0093] A detection method of strong loquat extract.

[0094] Among them, the verification method of Qiangli Loquat Lotion is:

[0095] 1) Establishment of standard detection method for Qiangli Loquat Lotion

[0096] 1) Take 10 parts of the standard Qiangli Loquat Lotion product, add diluent to it for dilution, set the volume to 5 times the volume of the original product, then heat it up to 50°C, keep it warm for 1 hour, and set it aside;

[0097]2) Filter the above-prepared solution with a microporous molecular membrane, collect the filtrate, add 40 parts of diluent to the filter residue, raise the temperature to 35°C, keep it warm for 30 minutes, and then filter again to obtain the filtrate a and filter residue, Add 40 parts of diluent to the filter residue again, raise the temperature to 45°C, keep the temperature for 45 minutes, and then filter to obtain filtrate b and filter residue, mix the filtrate, filtrate a and filtrate b evenly, and set aside;

[0098] 3) Put the c...

Embodiment 3

[0134] A detection method of strong loquat extract.

[0135] Among them, the verification method of Qiangli Loquat Lotion is:

[0136] 1) Establishment of standard detection method for Qiangli Loquat Lotion

[0137] 1) Take 10 parts of the standard Qiangli Loquat Lotion product, add diluent to it for dilution, and set the volume to 6 times the volume of the original product, then heat it up to 50°C, keep it warm for 1 hour, and set it aside;

[0138] 2) Filter the above-prepared solution with a microporous molecular membrane, collect the filtrate, add 30 parts of diluent to the filter residue, raise the temperature to 35°C, keep the temperature for 30 minutes, and then filter again to obtain the filtrate a and the filter residue. Add 45 parts of diluent to the filter residue again, raise the temperature to 45°C, keep the temperature for 45 minutes, and then filter to obtain filtrate b and filter residue, mix the filtrate, filtrate a and filtrate b evenly, and set aside;

[0...

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Abstract

The invention provides a detection method of strong loquat syrup. According to the method, a standard strong loquat syrup product is subjected to dilution extraction treatment, a solubilizer is added to increase the extraction amount of effective components in the medicament, meanwhile, the emulsification phenomenon is reduced, the standard strong loquat syrup product is selected as a standard spectrogram, and the situation that illegal merchants achieve detection qualification only by adding a single effective substance is avoided; and the phenomenon of adulteration is reduced. Before liquid chromatography, a thin layer chromatography is adopted for coarse analysis, whether a product is qualified or not is preliminarily determined, then a reasonable eluent and an elution sequence are designed, and high performance liquid chromatography is carried out on the product. Before a liquid chromatography test, a test solution needs to be filtered by using a modified filter membrane, so that impurities in the test solution are reduced, the detection speed and the detection accuracy are improved, and meanwhile, the service life of a chromatographic column is prolonged.

Description

technical field [0001] The invention relates to the technical field of medicine quality control, in particular to a detection method of strong loquat dew. Background technique [0002] Qiangli Loquat Loquat is composed of seven traditional Chinese medicines including loquat leaf, poppy shell, Baibu and Baiqian. : Used for the treatment of chronic cough, bronchitis, etc. Among them, loquat leaf is the monarch drug, and poppy shell is the main drug for treating cough in the prescription, containing morphine, codeine, papaverine, papaverine, protoopine and other alkaloid components. As we all know, the efficacy of Chinese patent medicine does not come from any single active ingredient, but the result of the joint action of multiple effective parts. Previously, only the identification and relative density were controlled in the quality standard of Qiangli Pipalou. These two items cannot characterize the quality of Qiangli Pipalu, and there are quality risks. The fingerprint c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/90
CPCG01N30/02G01N30/90G01N30/06Y02A50/30
Inventor 眭荣春胡军胡庭国邓晓军肖云
Owner JIANGXI UNIVERSE PHARMA
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