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Laboratory mouse breed conservation isolation device for gene editing

A gene editing and isolation device technology, applied in the field of gene editing, can solve the problems that feces cannot be cleaned in time, and the isolator cannot be opened frequently, so as to achieve the effect of avoiding the introduction of germs and cleaning thoroughly

Inactive Publication Date: 2021-11-16
李新朋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the shortcomings in the prior art that the isolator cannot be frequently opened in order to maintain a sterile environment, resulting in the inability to clean the feces produced by the experimental mice in the isolator in a timely manner, and proposes a gene Editorial mouse breeding isolation device

Method used

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  • Laboratory mouse breed conservation isolation device for gene editing
  • Laboratory mouse breed conservation isolation device for gene editing
  • Laboratory mouse breed conservation isolation device for gene editing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] refer to Figure 1-8 , a kind of experimental mouse species preservation isolation device for gene editing, comprising a base 28, the upper surface of the base 28 is sequentially stacked with several sealed boxes 1 along the height direction, and the bottom of each sealed box 1 is fixedly provided with several connecting plates 19 , the connection plate 19 is used for connection between different sealed boxes 1 . All in each sealed box body 1, be equipped with a rearing box 4 detachably by fixing mechanism, rearing box 4 is provided with dodge door 33, is provided with automatic water-feeding feeder in raising box 4. The sealing box 1 can be provided with a sleeve corresponding to the breeding box 4, and the sleeve is connected with rubber gloves. The inner bottom of each breeding box 4 is provided with several first through grooves 5 equidistantly along the width direction. The first through grooves 5 are arranged to allow the feces discharged by the experimental mice...

Embodiment 2

[0030] refer to Figure 4 As another preferred embodiment of the present invention, the difference from Embodiment 1 is that any side wall of the sealed box 1 is provided with a telescopic column 20, and the inner end of the telescopic column 20 is in contact with the outer surface of the rearing box 4. The outer end of the telescopic column 20 passes through the outer wall of the sealed box 1 and is fixedly equipped with a disc 21. A spring 22 is sleeved on the telescopic column 20 between the disc 21 and the outer wall of the sealed box 1. The two ends of the spring 22 The ends are respectively fixedly connected to the disc 21 and the sealing box 1, the outer surface of the disc 21 is fixedly equipped with a roller 23, and a drive shaft 32 is rotatably installed on the base 28 below the roller 23, and the top of the drive shaft 32 extends upwards to Located above the highest sealing box 1, several cams 24 corresponding to the rollers 23 are fixedly mounted on the drive shaft...

Embodiment 3

[0034] refer to Figure 1-2 , as another preferred embodiment of the present invention, the difference from Embodiment 2 is that the transmission mechanism includes a first sprocket 25, a second sprocket 26, and a chain 27, and the top end of the drive shaft 32 is fixedly mounted with a coaxial The first sprocket 25, the second sprocket 26 corresponding to the first sprocket 25 is fixedly installed on the main shaft 14 with the longest distance from the base 28, and a second sprocket 26 corresponding to the first sprocket 25 is installed between the first sprocket 25 and the second sprocket 26 chain27. The drive shaft 32 is used to drive the main shaft 14 to rotate by way of sprocket transmission.

[0035] In embodiment 2, be provided with the mechanism that is used for knocking raising box 4, this mechanism utilizes electric motor 29 to drive, in the present embodiment, by setting transmission mechanism between drive shaft 32 and main shaft 14, drive and drive in electric mo...

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Abstract

The invention relates to the technical field of gene editing, in particular to an laboratory mouse breed conservation isolation device for gene editing. A plurality of sealed box bodies are sequentially mounted on the upper surface of a base in a stacked manner in the height direction, a feeding box is detachably mounted in each sealed box body through a fixing mechanism, a plurality of first through grooves are formed in the inner bottom of each feeding box at equal intervals in the width direction, a movable rod is arranged on the inner wall of the sealing box body below each feeding box in a penetrating mode, a brush is fixedly installed at the tail end of the inner side of each movable rod, bristles of each brush make contact with the surface of the inner bottom of the corresponding sealing box body, the tail end of the outer side of each movable rod outwards extends out of the corresponding sealing box body, and the tail ends of the outer sides of the movable rods are in transmission connection to the same reciprocating motion mechanism, second through grooves corresponding to the brushes are formed in the surface of the bottom in each sealing box body, a funnel covering the second through grooves is fixedly installed on the surface of the bottom of each sealing box body, and a first movable gate is installed on each funnel. The laboratory mouse breed conservation isolation device has the advantage that sundries such as feces of laboratory mice can be conveniently and quickly cleaned.

Description

[0001] This application is a divisional application, the original patent number is: 202010683836.1, the application date is July 16, 2020, and the title of the invention is: an experimental mouse species preservation isolator for gene editing. technical field [0002] The invention relates to the technical field of gene editing, in particular to an isolation device for experimental mouse species used for gene editing. Background technique [0003] Gene editing, also known as genome editing or genome engineering, is an emerging and more precise genetic engineering technology or process that can modify specific target genes in the genome of an organism. Gene editing relies on genetically engineered nucleases, also known as "molecular scissors", to generate site-specific double-strand breaks at specific locations in the genome, inducing organisms to repair them through non-homologous end joining or homologous recombination, because This repair process is error-prone, leading to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K1/03A01K1/01A01K1/00A01K1/035
CPCA01K1/031A01K1/035A01K1/0047A01K1/01A01K1/0132
Inventor 不公告发明人
Owner 李新朋