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Polyvinyl alcohol sponge with ordered porous structure prepared based on 3D printing template

A polyvinyl alcohol sponge, 3D printing technology, applied in 3D object support structures, manufacturing tools, additive manufacturing, etc., to achieve the effects of improving hemostasis efficiency, shortening coagulation time, rapid guidance and absorption

Pending Publication Date: 2021-11-19
WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these hemostatic agents have certain limitations in the face of incompressible penetrating injuries

Method used

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  • Polyvinyl alcohol sponge with ordered porous structure prepared based on 3D printing template
  • Polyvinyl alcohol sponge with ordered porous structure prepared based on 3D printing template
  • Polyvinyl alcohol sponge with ordered porous structure prepared based on 3D printing template

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A polyvinyl alcohol sponge with an ordered porous structure prepared based on a 3D printing template, including a sponge body, the sponge body is provided with a number of hemostatic channel structures in regular and orderly arrays, and the hemostatic channel structure is cylindrical .

Embodiment 2

[0047]A polyvinyl alcohol sponge with an ordered porous structure prepared on the basis of a 3D printing template, including a sponge body, the sponge body is provided with a number of hemostatic channel structures in regular and orderly arrays, and the hemostatic channel structure is an upper large The lower small inverted cone structure, the large mouth of the inverted cone structure is the upper mouth located on the surface of the sponge body, and the small mouth is the lower mouth located inside the sponge body, the hemostatic channel structure of the inverted cone structure The taper is 1 / 2.

Embodiment 3

[0049] A polyvinyl alcohol sponge with an ordered porous structure prepared on the basis of a 3D printing template, including a sponge body, the sponge body is provided with a number of hemostatic channel structures in regular and orderly arrays, and the hemostatic channel structure is an upper large The lower small inverted cone structure, the large mouth of the inverted cone structure is the upper mouth located on the surface of the sponge body, and the small mouth is the lower mouth located inside the sponge body, the hemostatic channel structure of the inverted cone structure The taper is 2 / 3.

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Abstract

The polyvinyl alcohol sponge prepared based on the 3D printing template and provided with the ordered porous structure comprises a sponge body, a plurality of regular and ordered array hemostasis channel structures are arranged on the sponge body, each hemostasis channel structure is of a big-end-up inverted-cone-shaped structure, a big opening of each inverted-cone-shaped structure is an upper opening located in the surface of the sponge body, a small opening is the lower opening located inside the sponge body, and the taper of the hemostasis channel structure of the inverted-cone-shaped structure is 1 / 3-3 / 4, the sponge with the ordered micro-channels can quickly guide and absorb blood when making contact with the blood, a large number of regularly-arranged red blood cells gather in the micropore structure at the bottom of the sponge, According to the sponge prepared by combining the structured ordered microchannels and the disordered holes, the blood coagulation time is greatly shortened, and the hemostasis efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of hemostatic materials, in particular to a polyvinyl alcohol sponge with an ordered porous structure prepared based on a 3D printing template. Background technique [0002] Accidental trauma is an inevitable problem, and physiological hemostasis can alleviate the damage caused by accidental trauma to a certain extent. First, small blood vessels near the damaged vessel constrict, reducing local blood flow. Then locally damaged red blood cells release ADP and thrombin generated during local coagulation can activate platelets to release endogenous ADP and TXA2, thereby activating and recruiting more platelets, forming a platelet hemostatic plug to block the wound, and achieving preliminary hemostasis. Finally, coagulation factors are activated in a certain order to generate thrombin, which finally converts soluble fibrinogen in plasma into insoluble fibrin, and interweaves them into a network to strengthen th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/00A61L24/00A61L24/06B29C64/118B33Y80/00
CPCA61F13/00987A61L24/06A61L24/0036A61L24/0015B29C64/118B33Y80/00A61L2400/04A61F13/01042A61F13/01017A61F13/01021C08L29/04
Inventor 石长灿李鹏鹏杨啸曹丽娜桑峰陈叶祎季志孝潘璐琪
Owner WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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