Oral acid-resistant intestinal bacteria oil drop

A technology of intestinal bacteria oil and intestinal bacteria, which is applied in the field of oral acid-resistant enteric bacteria preparations, can solve the problems of poor compliance of capsule preparations, and achieve the effects of improved freeze-drying protection effect, increased survival rate, good emulsification and stability

Pending Publication Date: 2021-11-30
北京富玛特生物科技有限公司
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AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems in the application of the existing enterobacteria preparations, using gastric acid-resistant freeze-dried bacteria powder and a mild oil drop anaerobic protective layer, the enterobacteria oil drop formulation was prepared to improve the oral effectiveness of enterobacteria and overcome the need for infants and young children. The problem of poor compliance with capsule formulations

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  • Oral acid-resistant intestinal bacteria oil drop
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Embodiment Construction

[0015] The technical solutions in the embodiments of the present invention are clearly and completely described as follows:

[0016] Preparation of enteric bacteria: Soak 20g of fresh feces samples from healthy donors in 100mL of 0.9% sterile saline solution to obtain the original bacterial solution; centrifuge the original bacterial solution at 6000g for 10min, discard the supernatant; repeat washing 3 times , to obtain intestinal bacteria sludge.

[0017] Prepare lyoprotectant mother solution: weigh 6.0g inulin, 5.0g trehalose, 4.0g gelatin, add 85g PBS buffer solution of pH6.0-pH7.0 to prepare; sterilize at 115°C for 30min; put in 37°C water bath before use , to melt the mother liquor. L-ascorbic acid and poly-L-lysine were formulated into a 10-fold solution, sterilized by filtration, and stored in the refrigerator.

[0018] Preparation of enterobacteria freeze-dried powder: mix enterobacteria slime and freeze-drying protective agent mother liquor in a weight ratio of 4:6...

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Abstract

The invention discloses an oral acid-resistant intestinal bacteria oil drop and belongs to the technical field of biology. The oral acid-resistant intestinal bacteria oil drop is prepared from the following components in percentage by weight: 10%-20% of intestinal bacteria freeze-dried powder and 80%-90% of an edible vegetable oil emulsifying system. The oral oil drop uses a vegetable oil emulsion delivery system and multiple anti-gastric acid protection components, and remarkably improves oral effectiveness and use compliance of an intestinal bacteria agent.

Description

[0001] Applicant: Beijing Fumate Biotechnology Co., Ltd. [0002] Inventors: Zhang Jiashu, Liu Qiongming technical field [0003] The invention relates to the field of biotechnology, in particular to an oral acid-resistant enteric bacteria preparation. Background technique [0004] The traditional enterobacteria transplantation operation is complicated, the patient has a certain amount of pain, and it may damage the mucous membrane in the human cavity, which may cause adverse medical events. The main way to solve the problem of intestinal bacteria transplantation is to prepare the freeze-dried bacteria powder (US 2015037461A1, CN112472810 A, CN 109628311 A, CN 112195103 B) after mixing the intestinal bacteria and the freeze-dried protective agent, and then ingesting the human body orally. Oral enterobacteria preparations can avoid the intervention of gastroscopes, gastric tubes, jejunum tubes, colonoscopes and other instruments, reduce surgical injuries that damage the inte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/19A61K47/14A61K47/44A61K47/42A61K47/36A61K47/34A61K35/74A61P1/00
Inventor 张家树刘琼明
Owner 北京富玛特生物科技有限公司
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