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Application of parabacteroides dielsii in preparation of pharmaceutical preparation for treating Alzheimer's disease

A technology for Alzheimer's disease and pharmaceutical preparations, which is applied in the application field of Parabacteroides dischei in the preparation of Alzheimer's disease pharmaceutical preparations to achieve the effects of improving cognitive function and improving clinical symptoms

Pending Publication Date: 2021-12-07
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite this, there are currently no drugs that are disease-modifying and clearly slow disease progression

Method used

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  • Application of parabacteroides dielsii in preparation of pharmaceutical preparation for treating Alzheimer's disease
  • Application of parabacteroides dielsii in preparation of pharmaceutical preparation for treating Alzheimer's disease
  • Application of parabacteroides dielsii in preparation of pharmaceutical preparation for treating Alzheimer's disease

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Experimental program
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Embodiment 1

[0024] What the present embodiment takes is the administration mode that the live bacteria suspension of Parabacteroides distirii is taken orally (gavage), according to 1×10 9 The concentration of cfu / ml is 200ul / day for each mouse, orally administered once a day for 30 days. More convenient and safe oral preparations can be further developed in the future.

[0025] For AD model APP / PS1 mice (AD model mice are Thy1-APPsw / PSL166P transgenic mice (129S strain), referred to as APP / PS1 mice, from the Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, the small Mice were introduced from the Rebecca Radde laboratory in Germany. Transgenic mice were modeled: Thy1-APPKM670 / 671NL and Thy1-PS1L166P were co-injected into C57BL6J oocyte male prokaryotic cells, and the resulting male mice were further compared with C57BL / 6J mice Mating. (Radde et al.2006)), intragastric administration of Parabacteroides distirii can significantly reduce...

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Abstract

The invention relates to an application of parabacteroides dieldrii in preparation of a pharmaceutical preparation for treating Alzheimer's disease. According to the present invention, the pathological change of the Alzheimer's disease of the model mouse can be significantly relieved by performing intragastric administration on the Alzheimer's disease model APP / PS1 mouse with the paraBacteroides dieldrii, such that the paraBacteroides dieldrii may become the probiotic candidate object, and is used for the treatment of the Alzheimer's disease patient.

Description

technical field [0001] The invention belongs to the field of Alzheimer's disease, and in particular relates to the application of Parabacteroides dissimilarus in preparing pharmaceutical preparations for Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease that seriously threatens human health and quality of life, and is a common cause of dementia in the elderly. Globally, there are currently 30 million AD patients, and this number is expected to rise to 90 million by 2050 as the world population ages (Prince et al. 2015). China has the world's largest population of dementia patients, which has brought enormous pressure to society and families. The course of AD usually has three stages: preclinical, mild cognitive impairment (mild cognitive impairment, MCI) and dementia. The pathological manifestations of AD are mainly the plaques formed by the aggregation of extracellular amyloid beta (Aβ) widely present in the brain a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K9/10A61P25/28A23L33/135
CPCA61K35/74A61K9/10A61K9/0053A61P25/28A23L33/135A23V2002/00A23V2200/322
Inventor 陈生弟汤荟冬何一茜李彬寅
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE