Application of cyclosporine A in preparation of medicine for improving embryo implantation rate of patient suffering from repeated embryo implantation failure

Abstract

The invention discloses application of cyclosporine A in preparation of a medicine for improving the embryo implantation rate of a patient suffering from repeated embryo implantation failure. In the prior art, the cyclosporine A is used as an immunosuppressor or a medicine for preventing miscarriage and preventing abortion, the application proposes that the cyclosporine A can improve the embryo planting rate for the first time, and particularly discloses improvement of the embryo planting rate of secondary embryo transplantation of the patient suffering from the repeated embryo implantation failure, and the research result is different from that in the prior art. Specifically, according to the technical scheme, clinical application of the cyclosporine A can be effectively guided, and side effects caused by improper medication are avoided.

Description

technical field [0001] The invention belongs to in vitro fertilization-embryo transplantation derivative technology, and specifically relates to the application of cyclosporin A in the preparation of medicines for improving the implantation rate of embryos in patients with repeated embryo implantation failures. Background technique [0002] Fertility disorders affect about 18-20% of couples of childbearing age in my country, becoming the third largest category of diseases after cancer and cardiovascular and cerebrovascular diseases. In recent years, the level of ART has been improved and developed. The clinical pregnancy rate of In vitro fertilization-embryo transfer (IVF-ET) has increased to 50-60%, but the embryo implantation rate is still hovering at 30-40%. At present, the failure of embryo implantation is the bottleneck that restricts the further improvement of ART clinical pregnancy rate and live birth rate, and also brings great economic and mental pressure to patient...

AI Technical Summary

Problems solved by technology

Since 2005, there have been 13 diagnostic criteria for RIF. At present, the definition of RIF has not been unified, and there are disputes in terms of the number of embryo transfer cycles, the number and quality of transfer embryos, the stage and cycle type of transfer embryos, and age.

At present, there is still a lack of therapeutic effect of CsA in patients with embryo implantation failure, and the application of cyclosporine in the field of reproduction is still lacking in evidence-based medicine

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