Application of miRNA 21 in preparation of reagent for judging radiotherapy prognosis survival rate of head and neck squamous cell carcinoma patient infected by HPV (human papilloma virus)

A head and neck squamous cell carcinoma, survival rate technology, applied in the medical field, can solve problems affecting the quality of life, speech and swallowing dysfunction, etc., and achieve the effect of reducing tumor mortality
CN113774170AActive Publication Date: 2021-12-10HENAN CANCER HOSPITAL +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HENAN CANCER HOSPITAL
Publication Date
2021-12-10

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Abstract

The invention belongs to the technical field of medical treatment, and discloses application of miRNA 21 in preparation of a reagent for judging the radiotherapy prognosis survival rate of a head and neck squamous cell carcinoma patient infected by HPV. The reagent is used for quantitatively detecting the expression quantity of the miRNA 21. By detecting the expression conditions of HPV E6 / E7 mRNA and candidate ray sensitivity related miRNA in HPV positive head and neck tumor tissues before radiotherapy and through single-factor and multi-factor regression analysis, it is obtained that the HPV E6 / E7 mRNA and host miRNA 21 are co-expressed as independent prognosis factors influencing the head and neck tumors, and the HPV E6 / E7 mRNA and host miRNA 21 can be used for radiotherapy prognosis judgment of HPV infection positive head and neck tumor patients in China, reference is provided for making an individualized treatment scheme of the head and neck tumor, and finally the purpose of reducing the death rate of the head and neck tumor is achieved.
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Description

technical field

[0001] The invention belongs to the field of medical technology, and relates to the application, kit and screening method of miRNA 21 in the preparation of reagents for judging the survival rate of radiotherapy prognosis of HPV-infected head and neck squamous cell carcinoma patients. Background technique

[0002] Head and neck cancer (HNC) refers to malignant tumors located in the oral cavity, pharynx (oropharynx, nasopharynx, and hypopharynx) and larynx, and is the sixth most common malignant tumor in the world, accounting for about the total number of cancers in the world. 5%. Worldwide, approximately 880,000 new cases (including 377,713 oral cavity cancers, 316,020 pharyngeal cancers, and 184,615 laryngeal cancers) and 400,000 deaths were attributed to head and neck cancers in 2018. The five-year survival rate of head and neck tumors is only 40%-50%, and the major organs of the head and face are in charge of the functions of vision, hearing, smell, taste ...

Claims

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