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Application of miRNA 21 in preparation of reagent for judging radiotherapy prognosis survival rate of head and neck squamous cell carcinoma patient infected by HPV (human papilloma virus)

A head and neck squamous cell carcinoma, survival rate technology, applied in the medical field, can solve problems affecting the quality of life, speech and swallowing dysfunction, etc., and achieve the effect of reducing tumor mortality

Active Publication Date: 2021-12-10
HENAN CANCER HOSPITAL +1
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Problems solved by technology

Since the total dose of radiotherapy for head and neck tumors generally reaches 70Gy, patients often suffer from severe stomatitis, dry mouth, speech and swallowing dysfunction, etc., which greatly affect the quality of life

Method used

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  • Application of miRNA 21 in preparation of reagent for judging radiotherapy prognosis survival rate of head and neck squamous cell carcinoma patient infected by HPV (human papilloma virus)
  • Application of miRNA 21 in preparation of reagent for judging radiotherapy prognosis survival rate of head and neck squamous cell carcinoma patient infected by HPV (human papilloma virus)
  • Application of miRNA 21 in preparation of reagent for judging radiotherapy prognosis survival rate of head and neck squamous cell carcinoma patient infected by HPV (human papilloma virus)

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Embodiment 1

[0029] 1.1 Selection of research objects

[0030] New cases of head and neck squamous cell carcinoma (including tumors of the oral cavity, oropharynx, and hypopharynx) from January 2016 to December 2018 were selected.

[0031] The inclusion criteria are as follows: 1) aged over 18 years; 2) with definite histological or cytological diagnosis results, and the morphology is squamous cell carcinoma. The following primary head and neck squamous cell carcinomas will be included in this study (according to the International Classification of Diseases Oncology code): C00 lip; C01 tongue base; C02 other parts of tongue; C03 gingiva; C04 mouth floor; C05 palate; C06 oral cavity C09 tonsil; C10 oropharynx; C12 pyriform; C13 hypopharynx; C14 lips, oral cavity, other parts of pharynx; C32 (including all subclassifications); 3) positive HPV DNA test; 6 months without radiotherapy, chemotherapy or surgery; 5) signed the informed consent form, agreed to the questionnaire survey, collection ...

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Abstract

The invention belongs to the technical field of medical treatment, and discloses application of miRNA 21 in preparation of a reagent for judging the radiotherapy prognosis survival rate of a head and neck squamous cell carcinoma patient infected by HPV. The reagent is used for quantitatively detecting the expression quantity of the miRNA 21. By detecting the expression conditions of HPV E6 / E7 mRNA and candidate ray sensitivity related miRNA in HPV positive head and neck tumor tissues before radiotherapy and through single-factor and multi-factor regression analysis, it is obtained that the HPV E6 / E7 mRNA and host miRNA 21 are co-expressed as independent prognosis factors influencing the head and neck tumors, and the HPV E6 / E7 mRNA and host miRNA 21 can be used for radiotherapy prognosis judgment of HPV infection positive head and neck tumor patients in China, reference is provided for making an individualized treatment scheme of the head and neck tumor, and finally the purpose of reducing the death rate of the head and neck tumor is achieved.

Description

technical field [0001] The invention belongs to the field of medical technology, and relates to the application, kit and screening method of miRNA 21 in the preparation of reagents for judging the survival rate of radiotherapy prognosis of HPV-infected head and neck squamous cell carcinoma patients. Background technique [0002] Head and neck cancer (HNC) refers to malignant tumors located in the oral cavity, pharynx (oropharynx, nasopharynx, and hypopharynx) and larynx, and is the sixth most common malignant tumor in the world, accounting for about the total number of cancers in the world. 5%. Worldwide, approximately 880,000 new cases (including 377,713 oral cavity cancers, 316,020 pharyngeal cancers, and 184,615 laryngeal cancers) and 400,000 deaths were attributed to head and neck cancers in 2018. The five-year survival rate of head and neck tumors is only 40%-50%, and the major organs of the head and face are in charge of the functions of vision, hearing, smell, taste ...

Claims

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Application Information

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IPC IPC(8): C12Q1/70C12Q1/6886C12N15/11
CPCC12Q1/708C12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 郭兰伟杨福娜殷玉林
Owner HENAN CANCER HOSPITAL
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