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Application of miRNA 21 in the preparation of reagents for judging the prognosis and survival rate of HPV-infected head and neck squamous cell carcinoma patients after radiotherapy

A head and neck squamous cell carcinoma and survival rate technology, applied in the medical field, can solve problems affecting the quality of life, speech and swallowing dysfunction, etc., and achieve the effect of reducing tumor mortality

Active Publication Date: 2022-04-15
HENAN CANCER HOSPITAL +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Since the total dose of radiotherapy for head and neck tumors generally reaches 70Gy, patients often suffer from severe stomatitis, dry mouth, speech and swallowing dysfunction, etc., which greatly affect the quality of life

Method used

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  • Application of miRNA 21 in the preparation of reagents for judging the prognosis and survival rate of HPV-infected head and neck squamous cell carcinoma patients after radiotherapy
  • Application of miRNA 21 in the preparation of reagents for judging the prognosis and survival rate of HPV-infected head and neck squamous cell carcinoma patients after radiotherapy
  • Application of miRNA 21 in the preparation of reagents for judging the prognosis and survival rate of HPV-infected head and neck squamous cell carcinoma patients after radiotherapy

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Embodiment 1

[0029] 1.1 Selection of research objects

[0030] New cases of head and neck squamous cell carcinoma (including tumors of the oral cavity, oropharynx, and hypopharynx) from January 2016 to December 2018 were selected.

[0031] The inclusion criteria are as follows: 1) aged over 18 years; 2) with definite histological or cytological diagnosis results, and the morphology is squamous cell carcinoma. The following primary head and neck squamous cell carcinomas will be included in this study (according to the International Classification of Diseases Oncology code): C00 lip; C01 tongue base; C02 other parts of tongue; C03 gingiva; C04 mouth floor; C05 palate; C06 oral cavity C09 tonsil; C10 oropharynx; C12 pyriform; C13 hypopharynx; C14 lips, oral cavity, other parts of pharynx; C32 (including all subclassifications); 3) positive HPV DNA test; 6 months without radiotherapy, chemotherapy or surgery; 5) signed the informed consent form, agreed to the questionnaire survey, collection ...

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Abstract

The invention belongs to the field of medical technology, and discloses the application of miRNA 21 in the preparation of a reagent for judging the radiotherapy prognosis and survival rate of HPV-infected head and neck squamous cell carcinoma patients. The reagent is used to quantitatively detect the expression level of the miRNA 21. The present invention detects the expression of HPV E6 / E7 mRNA and candidate radiosensitivity-related miRNA in HPV-positive head and neck tumor tissue before radiotherapy, and obtains HPV E6 / E7 mRNA and host miRNA through single factor and multivariate regression analysis 21 co-expression is an independent prognostic factor affecting head and neck tumors, which can be used to judge the prognosis of head and neck cancer patients with positive HPV infection in my country, provide reference for the formulation of individualized treatment plans for head and neck cancer, and finally achieve the goal of reducing the risk of head and neck tumors. Objectives for tumor mortality.

Description

technical field [0001] The invention belongs to the field of medical technology, and relates to the application, kit and screening method of miRNA 21 in the preparation of reagents for judging the survival rate of radiotherapy prognosis of HPV-infected head and neck squamous cell carcinoma patients. Background technique [0002] Head and neck cancer (HNC) refers to malignant tumors located in the oral cavity, pharynx (oropharynx, nasopharynx, and hypopharynx) and larynx, and is the sixth most common malignant tumor in the world, accounting for about the total number of cancers in the world. 5%. Worldwide, approximately 880,000 new cases (including 377,713 oral cavity cancers, 316,020 pharyngeal cancers, and 184,615 laryngeal cancers) and 400,000 deaths were attributed to head and neck cancers in 2018. The five-year survival rate of head and neck tumors is only 40%-50%, and the major organs of the head and face are in charge of the functions of vision, hearing, smell, taste ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/70C12Q1/6886C12N15/11
CPCC12Q1/708C12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 郭兰伟杨福娜殷玉林
Owner HENAN CANCER HOSPITAL
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