Reaction system

Abstract

The invention discloses a reaction system. The reaction system comprises a reaction device and a filtering device., The reaction device comprises a body and a stirring device, the body comprises a reaction containing cavity and a communicating opening, the communicating opening is communicated with the reaction containing cavity, the stirring device comprises a driving device and a stirring piece, and the driving device is used for driving the stirring piece to rotate; the stirring part is located in the reaction containing cavity, the first sample inlet and the first sample outlet of the filtering device are communicated with the reaction containing cavity through the communicating opening, a first pump is arranged between the filtering device and the reaction device, and the first pump is used for conveying liquid in the reaction device into the filtering device. On one hand, the reaction device comprises the stirring device, so that materials in the reaction accommodating cavity can be quickly mixed to accelerate the reaction rate; and on the other hand, the drug generation reaction and the separation and purification of the final drug product can be completed in the same system, the loss of the main drug caused by intermediate processes such as multiple transfer and purification is avoided, and the purity and quality of the final product are improved at the same time.

Description

Technical field [0001] The present disclosure relates to the field of pharmaceutical technology reaction, particularly relates to a reaction system for preparing a medicament. Background technique [0002] In the normal process for preparing a medicament, generally it requires multiple steps in order to obtain a qualified preparing pharmaceutical formulations meet the clinical needs of the final product. In the long process of the preparation of a medicament for the chain, on the one hand inevitably after many procedures, via a variety of special containers, and by a plurality of filters, sterilization and other steps may cause the main drug adsorption occurs, degradation phenomena, while there is also a stirred, different container configuration, the transfer and mixing main drug residual loss, which may cause physical and chemical steps. Drugs impurities in full, whether the control is directly related to the clinical drug safety, therefore, how to control a range of impurities...

AI Technical Summary

Problems solved by technology

[0004] However, most of the existing filtration devices are separated from the reaction device, and there are problems such as the transfer residue between different containers that may cause the loss of the main drug, complicated operations, time-consuming and high labor costs, and for sterile raw materials or preparations, there are still problems Facing the problem of aseptic control with higher requirements and costs such as multi-link, multi-container equipment and environment

In addition, although a small part of the reaction device is connected to the filter device, that is, the solution after the reaction is filtered through the connected filter device to obtain the final product, but it is limited to a single one-way filtration, and the purity and quality of the final product cannot be guaranteed.

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