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Systems for automated handling of fluid samples into microfluidic droplets for in vitro diagnostic

A fluid, processor technology, applied in the direction of analyzing materials, instruments, etc., that can solve problems such as different samples that cannot be persuaded by doctors or examiners

Pending Publication Date: 2021-12-24
VERSITECH LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the absence of these containers and assemblies of microfluidic devices, it may not be convincing doctors or examiners to comfortably use the new technology to process a large number of different samples

Method used

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  • Systems for automated handling of fluid samples into microfluidic droplets for in vitro diagnostic
  • Systems for automated handling of fluid samples into microfluidic droplets for in vitro diagnostic
  • Systems for automated handling of fluid samples into microfluidic droplets for in vitro diagnostic

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Embodiment Construction

[0042] Several embodiments are described in the following description with reference to the figures.

[0043] The present disclosure provides a microfluidic platform for generating liquid droplets for analysis through the application of a robotic arm. First, a physical model was developed to describe the model. Second, the system is applied to the generation of droplets. Finally, the system is tested with different parameters.

[0044] The assembly presents 4 main parts that the user can interact with: (1) sample tube holder, (2) waste buffer reservoir, (3) microfluidic chip holder, and (4) PCR tube rack. We optimize assembly design by aligning all parts on the same axis. Therefore, having a liquid handler that moves along only 2 axes (Z and Y) is sufficient for our requirements. Three parts are required on hand to use this assembly: (1) sample tube, (2) microfluidic chip already pre-filled with oil, and (3) empty PCR tube. The sample tubes must be placed on the placemen...

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Abstract

An assembly, including hardware and software, for handling fluid samples to form emulsions. The assembly may include a robotic liquid handler to manipulate fluid from sample tubes to a cartridge, and to collect emulsions from the cartridge to vials. The assembly may apply pressure for the manipulation of fluid and emulsions within the body of the assembly. In some embodiments, the assembly may stop applying pressure to the fluid when a predefined condition is arrived. The change may indicate the endpoint of fluid manipulation is achieved.

Description

technical field [0001] An assembly for automating fluid sample processing for microfluidic droplet generation and associated methods is disclosed. Background technique [0002] As society progresses, the demand for biochemical and biological assays is increasing. For example, in the in vitro diagnostic (IVD) industry, huge numbers of patient samples are screened. Therefore, technological advancements in automation and high-throughput capabilities in IVD may help digest this demand. The recent emergence of droplet microfluidics enables the precise generation and manipulation of tiny droplets. The technique could aid operations in biological and chemical laboratories by precisely controlling fluids on microfluidic devices as small as a few square centimeters. Basically, thousands of uniformly sized droplets can be generated in the device every minute. These droplets serve as microreactors for the assay and can help replace the bulky vials and microtiter plates traditionall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/00
CPCG01N35/1065G01N2035/1034
Inventor 岑浩璋邓钰衡黃文豪张会生武通园
Owner VERSITECH LTD