Preparation method of CuS@Cur hybrid hydrogel dressing with light-operated antibacterial and self-healing functions

Abstract

The invention discloses a preparation method of a CuS@Cur hybrid hydrogel dressing with light-operated antibacterial and self-healing functions, which comprises the following steps of preparing CuS nanospheres by a hydrothermal method, and grafting polydopamine and curcumin on the surfaces of the CuS nanospheres under a water phase condition to form CuS@Cur nanospheres; and dispersing the CuS@Cur nanospheres in a p-eormylbenzoic acid modified sodium carboxymethyl cellulose solution to prepare a uniform dispersion liquid, and adding quaternary ammonium salt chitosan into the dispersion liquid to form the CuS@Cur self-healing antibacterial hydrogel. The hydrogel prepared by the method can realize rapid sterilization, has good biocompatibility and environmental adaptability, can be used for treating wounds with complex conditions, and obtains satisfactory results through corresponding antibacterial experiments and irregular wound healing experiments.

Description

technical field [0001] The invention relates to a preparation method of a self-healing antibacterial hydrogel for rapid sterilization, in particular to a preparation method of a CuS@Cur hybrid hydrogel dressing with light-controlled antibacterial and self-healing functions. Background technique [0002] In people's daily life, accidents may cause skin damage every day, and in the process of wound healing, bacterial infection often leads to poor wound healing, and deep infection may even bring more serious problems to the human body . According to relevant reports, bacterial infectious diseases account for one-third of the national mortality rate. At present, 25,000 people in Europe die every year due to bacterial infections. In today's society, people usually use antibiotics, antibacterial agents and inorganic metal salts to fight infections. Antibacterial agents are used for antibacterial treatment, but there are certain problems in these two antibacterial agents. Inorgani...

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Problems solved by technology

In addition, in order to effectively solve the problem that trauma is prone to failure under complex mechanical conditions and the treatment of complex shaped wounds, the present invention introduces benzene rings and aldehyde groups into the polymer skeleton of the hydrogel, and the aldehyde groups can be combined with quaternary ammonium chitosan The amino group on the molecule forms a dynamic chemical bond, the benzene ring forms a π-π conjugation with the curcumin on the CuS@Cur nanosphere, and the carboxymethyl group in the carboxymethylcellulose molecule also interacts with the quaternary ammonium chitosan molecule The quaternary ammonium salt side groups on the surface generate electrostatic adsorption, dynamic chemical bonds, π-π conjugation, and electrostatic adsorption are all reversible forces, making the hydrogel have the ability to self-repair after being damaged by external forces, which solves the problem of water Two major problems are that the gel is prone to failure under the action of external force and the ordinary bulk hydrogel cannot fit the special-shaped wound

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