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Transdermal patch of agomelatine

The technology of a transdermal patch and an adhesive is applied to the transdermal patch containing agomelatine and the fields of its medical application and preparation, and can solve the problem of affecting the safety of medication, being difficult to reproduce, and having poor formulation stability. And other issues

Pending Publication Date: 2022-01-04
CHANGZHOU HANSOH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing preparations or processes are complex and difficult to reproduce, or the stability of the preparations is not good, which affects the safety of medication

Method used

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  • Transdermal patch of agomelatine
  • Transdermal patch of agomelatine
  • Transdermal patch of agomelatine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Adhesive matrix layer prescription composition:

[0059]

[0060]

[0061] Preparation method: Stir and dissolve the prescribed amount of DURO-TAK 387-2287, DURO-TAK 87-4098, isopropyl myristate, dimethylacetamide, lactic acid and ethyl acetate, add agomelatine, stir Evenly, the obtained medicated ointment is evenly coated on the protective layer, dried to remove the solvent, and after laminating with the backing layer as the preparation, cut into the set size and shape, the external patch of the present invention can be obtained .

Embodiment 2

[0063] Adhesive matrix layer prescription composition:

[0064]

[0065] Preparation method: Stir and dissolve the prescribed amount of DURO-TAK 387-2287, DURO-TAK 87-4098, isopropyl myristate, dimethylacetamide, lactic acid and ethyl acetate, add agomelatine, stir Evenly, the obtained medicated ointment is evenly coated on the protective layer, dried to remove the solvent, and after laminating with the backing layer as the preparation, cut into the set size and shape, the external patch of the present invention can be obtained .

Embodiment 3

[0067] Adhesive matrix layer prescription composition:

[0068]

[0069]

[0070] Preparation method: Stir and dissolve the prescribed amount of DURO-TAK 387-2287, DURO-TAK 87-4098, isopropyl myristate, dimethylacetamide, lactic acid and ethyl acetate, add agomelatine, stir Evenly, the obtained medicated ointment is evenly coated on the protective layer, dried to remove the solvent, and after laminating with the backing layer as the preparation, cut into the set size and shape, the external patch of the present invention can be obtained .

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Abstract

The invention provides a transdermal patch of agomelatine and a preparation method of the transdermal patch. Specifically, the transdermal patch of agomelatine comprises (a) a backing layer, (b) an adhesive matrix layer and (c) a protective layer, the adhesive matrix layer contains agomelatine and an adhesive matrix, and optionally, the transdermal patch of agomelatine further comprises a penetration enhancer. The agomelatine prepared by the invention is high in transdermal absorption rate and transdermal absorption amount, and has the characteristics of stability, high efficiency, good uniformity and low irritation, and the preparation method is simple.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and mainly relates to a transdermal patch containing agomelatine and its medical application and preparation method. Background technique [0002] Depression is a common, relapsing and highly disabling mental illness. Based on the discovery of the pharmacological mechanism of antidepressants, the hypothesis of the pathological mechanism of the abnormal function of the monoamine transmitter system in depression is proposed. The main mechanism of action of the existing antidepressants is to regulate the monoamine transmitter system. Although new antidepressants have been greatly improved in terms of safety and tolerability, there are still some problems such as slow onset of action, poor curative effect in some patients, and possible adverse reactions in long-term treatment. There are still great gaps in treatment. room for improvement [0003] Agomelatine is a new type of antidepressan...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/165A61K47/32A61P25/24
CPCA61K9/7053A61K31/165A61P25/24
Inventor 韩德强赵娜范录云
Owner CHANGZHOU HANSOH PHARM CO LTD
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