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A kind of preparation method of safe and long-acting multifunctional wound dressing

A wound dressing, multi-functional technology, applied in bandages, absorbent pads, medical science, etc., can solve the problem of killing bacteria, normal cell growth inhibition, etc., achieve good safety, stability and bactericidal performance, improve blood compatibility, The effect of improving blood compatibility

Active Publication Date: 2022-06-07
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of this, the biggest disadvantage of quaternary ammonium salt antibacterial materials is that they can significantly inhibit the growth of normal cells while killing bacteria.

Method used

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  • A kind of preparation method of safe and long-acting multifunctional wound dressing
  • A kind of preparation method of safe and long-acting multifunctional wound dressing
  • A kind of preparation method of safe and long-acting multifunctional wound dressing

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preparation example Construction

[0026]The present invention discloses a safe and long-acting method for the preparation of multifunctional wound dressings, comprising the following steps:

[0027] (1) Synthesis of quaternary ammonium methacrylate compound (QAC): 2-(dimethylamino)ethyl methacrylate and 1-bromodecane are reacted with acetonitrile as a solvent, deoxygenated, and dried after stirring to obtain QAC, and the prepared QAC has a crosslinkable double bond structure.

[0028] (2) Preparation of styrene sulfonate / acrylic acid / QAC composites: SSNa and / or AA and / or QAC and substrate are dissolved in organic solvents, the substrate is selected polyethersulfone PES or polyvinylidene or polysulfone, after oxygen removal treatment, with azo diisobutyro and N, N'-methylene bisacrylamide as initiators and crosslinkers to prepare SSNA / AA / QAC composite crosslinking solution, initiators and crosslinkers are added after deoxygenation treatment. The total mass ratio of SSNa, AA and QAC is 1 to 6%, and the m...

Embodiment 1

[0032]SSNa, AA and QAC 2 g each added to 82 mL N, N'-dimethylacetamide (DMAc) dissolved in 12 g PES, the preparation method is as described above, after oxygenation, add 1 wt% initiator azo diisobutyro and 2 mol% crosslinker N, N'-methylenebisacrylamide, 80 °C oil bath and nitrogen protection conditions reaction for 12 h, cooled to room temperature after the end of the reaction, defoamered for 30 min, SSNA / AA / QAC composite crosslinking solution is poured on the glass surface treated with piranha solution, the scraping film speed is 3~8cm / s, the standing time is 10~50 s, and the SSNA / AA / QAC multifunctional biofilm is obtained by throwing obliquely into the water.

Embodiment 2

[0034] SSNa, AA 3 g each added 82 mL DMAc dissolved in 12 g PES, the preparation method is as described above, after oxygen removal, add 1 wt% initiator azo diisobutyrin and 2 mol% crosslinking agent N, N'-methylene biacrylamide, 80 °C oil bath and nitrogen protection conditions reaction for 12 h, cooled to room temperature after the end of the reaction, the SSNA / AA composite crosslinking solution was poured on the glass surface treated with piranha solution, scraping film speed of 3 ~ 8 cm / s, The standing time is 10 to 50 s, and the SSNA / AA multifunctional biofilm is obtained by throwing obliquely into the water.

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Abstract

The invention discloses a preparation method of a safe and long-acting multifunctional wound dressing, belonging to the technical field of biomedical materials, comprising the following steps: S1. Synthesizing quaternary ammonium methacrylate (QAC); S2. Preparing sodium styrene sulfonate (SSNa) / acrylic acid (AA) / QAC composite solution; S3. Preparation of SSNA / AA / QAC multifunctional biofilm. The present invention prepares multifunctional biofilm by in-situ cross-linking polymerization copolymerization method, introduces biologically active groups such as sulfonic acid group and carboxyl group and QAC on the surface of the biofilm, and utilizes the bioactive group to improve the hemocompatibility and cell phase of the dressing surface. Capacitive, using QAC to impart excellent antimicrobial properties to dressings. The preparation method of the wound dressing is simple and easy, and the cost is low. At the same time, because the three monomers form an interpenetrating cross-linked structure, its biological functionality and antibacterial performance are safe and durable, and it is not easy to cause bacterial drug resistance. It is suitable for biomedical field.

Description

Technical field [0001] The present invention relates to the field of biopolymer material technology, specifically to a safe and long-acting multifunctional wound dressing preparation method. Background [0002] Wound dressings have been widely used in the clinical field, with the improvement of human living standards, the traditional single function of wound dressings can no longer meet people's requirements. Studies have shown that the biocompatibility of biomaterials is mainly determined by surface / interface properties, and the ideal wound dressing surface / interface should have excellent hematological compatibility, cell compatibility and antibacterial properties. However, natural or synthetic biomaterials have long-term inability to meet application needs. At the same time, in order to impart antibacterial properties to the material, researchers often introduce silver nanoparticles or other antibiotics as fungicides. However, these fungicides cannot bind to the substrate fixat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18C08F283/00C08F212/14C08F220/06C08F220/34C08F222/38C08L51/08A61L15/24A61L15/42A61L15/46
CPCC08J5/18C08F283/00A61L15/24A61L15/46A61L15/42C08J2351/08A61L2300/208A61L2300/404C08F212/30C08F220/06C08F220/34C08F222/385C08L51/08
Inventor 王翎任明伟华叶玮刘静静管盈盈
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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