Pharmaceutical composition of benzoylmetronidazole

Abstract

The invention relates to a pharmaceutical composition. The pharmaceutical composition comprises benzoylmetronidazole and a pharmaceutically acceptable stabilizer or carrier. According to the pharmaceutical composition of the invention, the benzoylmetronidazole and the stabilizer or the carrier are prepared into the composition, the composition can be quickly dispersed and dissolved out after being orally taken, the blood concentration of the active ingredient benzoylmetronidazole can quickly reach a peak value, and the quick exertion of the anti-infection effect is promoted.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a benzoyl metronidazole pharmaceutical composition and a preparation method thereof. Background technique [0002] Compared with adults, children's immune function is not yet fully developed, and their resistance to pathogens is insufficient. Once infected, they are prone to develop high fever. If not treated in time, they will quickly develop into more serious systemic infections and organ damage. Therefore, anti-infective drugs for children should have the ability to act quickly, control the development of infection in time and relieve the discomfort caused by inflammation. Metronidazole is a nitroimidazole antibacterial drug with killing activity against anaerobic bacteria and certain protozoan parasites, and it is also the drug of choice for mild to moderate Clostridium difficile infections. However, the bitter taste of metronidazole is unpleasant, especially for children...

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Problems solved by technology

But this document uses organic solvent, and medicine has very strict limit to the residual amount of toxic solvents such as organic solvent especially acetone, dichloromethane, requires the volatilization process of certain hour (12 hours) to get rid of above-mentioned organic solvent

This makes it difficult to control the process conditions. First, the container must be open, and the volatilization rate of the solvent is affected by many factors such as the position of the opening, the size of the opening, the velocity of the gas above the liquid, and the temperature of volatilization. The concentration of the stabilizer changes. Irregularity; secondly, long-term exposure makes the solution more susceptible to dust and microorganism pollution in the air, and has higher requirements on the air environment for preparation processing; thirdly, organic solvents pollute the environment, requiring the production workshop to arrange solvent recovery equipment , and the safety management of flammable and explosive solvents, all of which increase the cost of production and management

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