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A method for detecting compounds containing dota rings or nota rings in samples

A technology for detecting samples and compounds, which is applied in the field of analytical chemistry and can solve problems such as difficulty in quantitative detection of compounds

Active Publication Date: 2022-03-29
BEIJING SINOTAU INT PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] If the compound containing DOTA ring or NOTA ring has a highly active DOTA ring or NOTA ring, it can react with the metal ions that may exist in conventional diluents and glass containers at room temperature. Therefore, the compound containing DOTA ring or NOTA ring Quantitative detection of

Method used

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  • A method for detecting compounds containing dota rings or nota rings in samples
  • A method for detecting compounds containing dota rings or nota rings in samples
  • A method for detecting compounds containing dota rings or nota rings in samples

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Take (S,E)-2,2',2'-(10-(2-((6-amino-1-((4'-((8-amino-1-hydroxyl-5,7-disulfide Phthalocyanine-2-yl)diazo)-3,3'-dimethyl-[1,1'-biphenyl]-4-yl)amino)-1-oxalkane-2-yl)amino )-2-oxyethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacyl)triacetic acid sample, dissolved and diluted with diluent 2 to make a theoretical concentration of 20 μg / ml solution was tested.

Embodiment 2

[0091] Take (S,E)-2,2',2'-(10-(2-((6-amino-1-((4'-((8-amino-1-hydroxyl-5,7-disulfide Phthalocyanine-2-yl)diazo)-3,3'-dimethyl-[1,1'-biphenyl]-4-yl)amino)-1-oxalkane-2-yl)amino )-2-oxyethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacyl)triacetic acid sample, dissolved and diluted with diluent 3 to make a theoretical concentration of 20 μg / ml solution was tested.

Embodiment 3

[0093] Take (S,E)-2,2',2'-(10-(2-((6-amino-1-((4'-((8-amino-1-hydroxyl-5,7-disulfide Phthalocyanine-2-yl)diazo)-3,3'-dimethyl-[1,1'-biphenyl]-4-yl)amino)-1-oxalkane-2-yl)amino )-2-oxyethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacyl)triacetic acid sample, dissolved and diluted with diluent 4 to make a theoretical concentration of 20 μg / ml solution was tested.

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Abstract

The present invention provides a method for detecting compounds containing a DOTA ring or a NOTA ring contained in a sample, wherein the compound containing a DOTA ring is, for example, (S, E)-2,2',2'-(10-(2- ((6‑amino‑1‑((4'‑((8‑amino‑1‑hydroxy‑5,7‑dithiophthalocyanine‑2‑yl)diazo)‑3,3'‑dimethyl‑ [1,1'-biphenyl]-4-yl)amino)-1-oxalkane-2-yl)amino)-2-oxyethyl)-1,4,7,10-tetraazacycle Dodecane-1,4,7-triacyl)triacetic acid or oxyoctreotide, the method comprises the steps of: using a diluent to dilute the sample, and using high performance liquid chromatography to detect the diluted sample, wherein The diluent comprises pentetic acid. The method of the invention solves the problem of the accuracy of content determination of compounds containing DOTA rings or NOTA rings. Among other things, method specificity, sensitivity, linearity and range, and solution stability were all verified to be good.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, in particular to a method for detecting compounds containing DOTA rings or NOTA rings in samples. Background technique [0002] The DOTA ring refers to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracarboxylic acid, which is a twelve-membered tetraazamacrocyclic ligand, which is essentially a ring The product in which the hydrogens on the four nitrogens in lenamine are replaced by acetic acid groups. The NOTA ring refers to 1,4,7-triazacyclononane-1,4,7-tricarboxylic acid, which is a nine-membered triazamacrocyclic ligand, which is essentially triethylenetriamine A product in which three hydrogens on nitrogen are replaced by acetic acid groups. [0003] If the compound containing DOTA ring or NOTA ring has a highly active DOTA ring or NOTA ring, it can react with the metal ions that may exist in conventional diluents and glass containers at room temperature. Therefore, the compound containing ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/34G01N30/36
CPCG01N30/02G01N30/34G01N30/36
Inventor 李春玲张长亮
Owner BEIJING SINOTAU INT PHARMA TECH CO LTD
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