Microcarrier bioreactor tank inner and outer pipeline channel sealing connection device

A technology for bioreactors and connecting devices, applied in bioreactor/fermenter combinations, specific-purpose bioreactors/fermenters, enzymology/microbiology devices, etc., can solve problems such as wear failure, cell contamination, etc. To achieve the effect of simple structure, convenient insertion and disassembly

Pending Publication Date: 2022-02-22
LANZHOU BAILING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dynamic seal 20 may wear out and fail at any time during the long-term rotation of the stirring shaft 17, thereby bringing the risk of contamination of the cells cultured in the tank.

Method used

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  • Microcarrier bioreactor tank inner and outer pipeline channel sealing connection device
  • Microcarrier bioreactor tank inner and outer pipeline channel sealing connection device
  • Microcarrier bioreactor tank inner and outer pipeline channel sealing connection device

Examples

Experimental program
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Embodiment Construction

[0030] Such as Figure 2~12 As shown, a microcarrier bioreactor tank internal and external channel sealing connection device, the device includes a hard tube 1, a sealing connection seat 3, a sealing connection sleeve 4 and a compression nut 5. The hard tube 1 is fixed on the microcarrier frame 14 in the reaction tank 13, and one end passes through the top cover 15 of the reaction tank 13; the top cover 15 is provided with a threaded interface 2, and the threaded interface 2 is connected with the sealing connection seat 3; The sealing connection seat 3 is provided with a sealing connection sleeve 4 inserted on the hard pipe 1, and a compression nut 5 is pressed on the sealing connection sleeve 4; the compression nut 5 is connected with the sealing connection seat 3; the sealing connection seat 3 is connected with the Sealing rings 22 are arranged in the sealing connection sleeves 4 .

[0031] Wherein: the top of the hard tube 1 is the channel inlet 21, and its end extends int...

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PUM

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Abstract

The invention relates to a microcarrier bioreactor tank inner and outer pipeline channel sealing connection device. The device comprises a hard pipe, a sealing connection seat, a sealing connection sleeve and a compression nut. The hard pipe is fixed on a microcarrier frame in a reaction tank, and one end of the hard pipe penetrates through a top cover of the reaction tank; the top cover is provided with a threaded connector, and the threaded connector is connected with the sealing connecting seat. The sealing connecting sleeve which is inserted on the hard pipe in a sleeving manner is arranged in the sealing connecting seat; the compression nut is pressed on the sealing connecting sleeve; the compression nut is connected with the sealing connecting seat; and sealing rings are arranged in the sealing connecting seat and the sealing connecting sleeve. The internal and external pipelines of a microcarrier bioreactor tank can be conveniently connected in a static sealing mode, and compared with the existing dynamic sealing connection mode, the device is safer and more reliable, and the structure is simpler.

Description

technical field [0001] The invention relates to the technical field of bioreactor design, in particular to a sealing connection device for internal and external pipeline channels of a microcarrier bioreactor tank. Background technique [0002] In the reaction tank 13 of the microcarrier bioreactor, a microcarrier frame 14 needs to be set. Due to the obstruction of the microcarrier frame plate, the bent or circular ventilation pipeline cannot be directly inserted into the cell culture area 16 from the tank top cover 15 . The current solution is to figure 1 As shown: an air channel 18 is set at the center of the stirring shaft 17, and is connected with the joint 19 outside the reaction tank 13, so as to access the conveying gas, but this structure needs to be set between the rotating stirring shaft 17 and the stationary joint 19. A seal 20 is used to maintain the airtightness between the inside and outside of the reaction tank 13 . However, the dynamic seal 20 may wear out a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00F16L15/00F16L21/02
CPCC12M37/04F16L15/00F16L21/02
Inventor 马作霖马忠仁杨德庆崔纬强
Owner LANZHOU BAILING BIOTECH CO LTD
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