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Traditional Chinese medicine film agent for treating burns and scalds as well as preparation method and application of traditional Chinese medicine film agent

A technology for burns and traditional Chinese medicine, which is applied in the direction of medical formulas, medical preparations containing active ingredients, anti-toxins, etc. It can solve the problems of poor compliance of existing preparations, limited gelatin resources, and high production costs, so as to increase the quantity and The ability to scavenge oxygen free radicals, promote wound healing, and less irritating effect

Active Publication Date: 2022-03-08
HUBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the limited resources of gelatin sourced from mammals in the prior art, the relatively high production cost, and the possibility of causing zoonotic diseases and poor compliance of existing preparations, a traditional Chinese medicine film for treating burns and scalds and its preparation method and application are provided

Method used

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  • Traditional Chinese medicine film agent for treating burns and scalds as well as preparation method and application of traditional Chinese medicine film agent
  • Traditional Chinese medicine film agent for treating burns and scalds as well as preparation method and application of traditional Chinese medicine film agent
  • Traditional Chinese medicine film agent for treating burns and scalds as well as preparation method and application of traditional Chinese medicine film agent

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0076] Preparation Example 1 Preparing a fish scale gelatin by an enzymatic solution

[0077] Wash the grassfish fish scales, dry after drying with a high speed multifunctional pulverizer into a flocculation. 0.4 mol / L of a hydrochloric acid solution was added to the shaped fish scales in a proportion of solid-liquid ratio of 1: 15 (g / ml), and the mixture was soaked even after stirring. The hydrochloric acid solution was removed and filled with ultrapure water until the pH is neutral (pH of 7). After adding water to the filter residue in a ratio of a solid-liquid ratio of 1:10 (g / ml), Protease A was added to 5 h at 35 ° C. The enzymatic sample was filtered with 100 mesh filtration, and the filter residue was subjected to 3 times with ultrapure water, and the mixture was stirred for 15 min or more, and then 10 min was heated at 90 ° C. After drying samples at 37 ° C, the dry fish scales were obtained after 5 hedition of 55 ° C, and the pH was subjected to a ratio of 1: 10 (g ...

preparation example 2

[0080] Preparation Example 2 Preparation of Traditional Chinese Medicinal Membrane A1

[0081] Take 10 g of the fish scale gel, 50 ml of pure water soaked, so that it is fully swelling. Weigh 1g of the tiger cum extract, after grinding 120 mesh sieve, standby. The water-absorbing fish scales were heated in a water bath after water-absorbing water to heat it, and 3 g of glycerol was added, stirred well. The tigpes extract powder was added to the glue, and the mixture was mixed to 100 mL, mixed with pure water to 100 ml, mix well, vacuum-containing, and contain 10% by mass of fish scale gel, 1 quality % Of the tigpes extract and 3% by mass of glycerin. Under the conditions of heat preservation at 40 ° C, the coating glue is applied to the PVC template, and after cooling, the heat is dry, and the heat dry is released, and the dose, packaging, and After sterilization. This product contains no less than 2.5 mg per piece.

preparation example 3

[0082] Preparation Example 3 Preparation of Traditional Chinese Medicine Membrane A2

[0083] Take 10 g of the fish scale gel, add 60 ml of pure water soaking gelatin to make it fully swell. Weigh 1.5G, after grinding, after grinding. The water-absorbing fish scales were heated in a water bath at 60 ° C to dissolve, and 3 g of glycerol was added, stirred with stirring. The tigpes extract powder was added to the glue, and the mixture was mixed to 100 mL, mixed with pure water to 100 mL, mix well, vacuum, gave it, the drug-containing glue contained 10% by mass of fish scale gel, 1.5 quality % Of the tigpes extract and 3% by mass of glycerin. Under the conditions of heat preservation at 50 ° C, the coating glue is applied to the PVC template using a coater, and after cooling, the hot air is dried, and the heat dry is released, and the dose, packaging, and After sterilization. This product contains no less than 2.5 mg per piece.

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Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a traditional Chinese medicine film agent for treating burns and scalds and a preparation method and application thereof. The method comprises the following steps: (1) extracting fish scale gelatin by adopting an enzymolysis method; (2) adding water into fish scale gelatin for soaking, then heating and dissolving the fish scale gelatin which absorbs water and swells in a water bath at 40-80 DEG C, then adding glycerol, and stirring to obtain mucilage; (3) adding ground polygonum cuspidatum extract powder which is sieved by a 120-mesh sieve into the mucilage, stirring, adding water, mixing, and carrying out vacuum defoaming to obtain drug-containing mucilage; and (4) uniformly coating a template with the drug-containing adhesive cement under the condition of heat preservation at 20-80 DEG C, cooling and solidifying, drying, demolding, and then performing dose division, packaging and sterilization. According to the traditional Chinese medicine film agent, gelatin produced by taking fish scales as a raw material is taken as a main auxiliary material, a polygonum cuspidatum extract (the main effective component is polydatin) is taken as a medicine, a dosage form is selected as a film agent, and the polydatin fish scale gelatin film is prepared for treating burns and scalds.

Description

Technical field [0001] The present invention relates to the technical field of traditional Chinese medicine preparations, and more particularly to a traditional Chinese medicine membrane agent and a preparation method thereof, a preparation method thereof. Background technique [0002] Burnt burns refers to damage caused by boiling water (oil), firing, electricity, light or chemical, which contains skin or mucosal damage, severe subjects, may hurt skin tissue, such as muscles, bones, joints or even internal organs. It is one of the skin sexual injuries with the highest incidence in daily life and work, is a common and extremely complex trauma disease. With the continuous expansion of social lifestyles and space, the number of injured has also increased year by year, especially children, teens and elderly people. According to statistics, there are approximately 20 million people a year to varying degrees of burnt burns every year, in which the number of hospitalizations accounts f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K9/70A61K47/42A61P17/02A61P39/06
CPCA61K36/704A61K9/7007A61K47/42A61P17/02A61P39/06Y02A50/30
Inventor 颜春潮陈运中
Owner HUBEI UNIV OF CHINESE MEDICINE
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