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Triple inactivated vaccine for preventing and treating duck circovirus disease, novel duck reovirus disease and duck adenovirus type 3 and preparation method of triple inactivated vaccine

A duck circovirus, reovirus technology, applied in chemical instruments and methods, biochemical equipment and methods, vaccines, etc., can solve problems such as ineffectiveness, achieve low cost, high vaccine titer content, and preparation methods simple effect

Pending Publication Date: 2022-03-22
哈药集团生物疫苗有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there are no effective measures for the prevention and control of these three diseases, so it is particularly important to develop a safe and effective triple inactivated vaccine as soon as possible

Method used

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  • Triple inactivated vaccine for preventing and treating duck circovirus disease, novel duck reovirus disease and duck adenovirus type 3 and preparation method of triple inactivated vaccine
  • Triple inactivated vaccine for preventing and treating duck circovirus disease, novel duck reovirus disease and duck adenovirus type 3 and preparation method of triple inactivated vaccine
  • Triple inactivated vaccine for preventing and treating duck circovirus disease, novel duck reovirus disease and duck adenovirus type 3 and preparation method of triple inactivated vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of Example 1 Triple Inactivated Vaccine for Duck Circovirus Disease, New Duck Reovirus Disease and Type 3 Duck Adenovirus Disease

[0031] 1. Poison species

[0032] Novel duck reovirus S strain (microorganism preservation number: CGMCC No.20000, its classification name is: new duck reovirus, preservation time is: July 6, 2020, preservation unit is: China Microbial Strains The General Microbiology Center of the Preservation Management Committee, the preservation address is: No. 3, No. 1 Courtyard, Beichen West Road, Chaoyang District, Beijing, Institute of Microbiology, Chinese Academy of Sciences) is separated, identified, kept and supplied by Harbin Pharmaceutical Group Biological Vaccine Co., Ltd.

[0033] 2. Preparation and testing of inactivated vaccines

[0034] 2.1 Preparation of duck circobaculovirus

[0035] 2.1.1 Design and synthesis of duck circovirus CAP gene

[0036] After the duck circovirus cap gene was codon-optimized, EcoRI and Hind III r...

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Abstract

The invention discloses a triple inactivated vaccine for preventing and treating duck circovirus disease, novel duck reovirus disease and duck adenovirus type 3 and a preparation method of the triple inactivated vaccine. The triple inactivated vaccine comprises an effective amount of inactivated antigen and an immunologic adjuvant in immunization, the inactivated antigen comprises a duck circovirus antigen, a novel duck reovirus antigen and a duck adenovirus type 3 antigen. The invention further discloses a method for preparing the triple inactivated vaccine. The 3-type triple inactivated vaccine for preventing and treating the duck circovirus disease, the novel duck reovirus disease and the duck adenovirus disease is good in safety, and mutual interference or influence of antigen components cannot be generated. Immune protection efficacy tests prove that the triple inactivated vaccine can prevent duck reovirus, duck circovirus and duck adenovirus type 3 at the same time, can avoid adverse reactions caused by multiple inoculation immunization, and has the advantages of simple preparation method, convenience, multiple effects, low cost, high vaccine titer content and the like.

Description

technical field [0001] The invention relates to a triple inactivated vaccine for preventing and treating duck virus disease, in particular to a triple inactivated vaccine for simultaneously preventing and treating duck circovirus disease, new type duck reovirus disease and duck adenovirus disease type 3. The invention further relates to the The invention discloses a method for preparing a triple inactivated vaccine, which belongs to the field of triple inactivated vaccines for preventing and treating duck circovirus disease, new type duck reovirus disease and duck adenovirus disease type 3 and the preparation thereof. Background technique [0002] Duck circovirus mainly invades the immune system of the host, resulting in low immune function of the host, which can easily lead to double or even multiple infections, resulting in huge economic losses. Duck circovirus cannot proliferate in various cell lines and chicken embryos, so it is difficult to prepare a vaccine by isolatin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/295
CPCA61K39/12A61K39/39A61P31/14A61P31/20C12N15/86C12N7/00C07K14/005A61K2039/552A61K2039/5252A61K2039/55511A61K2039/70C12N2710/14043C12N2750/10034C12N2720/12234C12N2710/10034C12N2710/10021C12N2720/12221C12N2750/10022C12N2800/107C12N2800/22
Inventor 宋扬孙凯徐刚李应鹤于镭李倩冯艳男李婷婷胡秀艳刘洋曹宝珠
Owner 哈药集团生物疫苗有限公司
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