Metastable and stable crystal forms of pyroxasulfone as well as preparation method and application of metastable and stable crystal forms of pyroxasulfone

Abstract

The invention provides pyroxasulfone metastable-state and stable-state crystal forms, a preparation method and application, the preparation method comprises the following steps: step 1, stirring and heating pyroxasulfone in a first compound solvent to completely dissolve solids, cooling and crystallizing, filtering and drying to obtain white fine-needle-shaped crystals, namely the metastable-state fine-needle-shaped crystal form A; and 2, mixing the metastable-state fine-needle-shaped crystal form A and a second compound solvent in a pressure kettle, pressurizing in an inert gas atmosphere, keeping the temperature and pressure, keeping the reaction kettle sealed, reacting, cooling, crystallizing, relieving the pressure, filtering and drying to obtain a semitransparent columnar crystal B, namely the stable-state columnar crystal form B. The invention also discloses a preparation method of the stable-state fine-needle-shaped crystal form B. The stable-state fine-needle-shaped crystal form B is prepared from the metastable-state fine-needle-shaped crystal form A and the stable-state columnar crystal form B. The crystal form B subjected to high-temperature, high-pressure and high-supersaturation-degree treatment is a stable-state crystal form, so that the crystal form B is better in stability, lower in hygroscopicity and convenient to store, and single-dosage-form or compound-dosage-form wettable powder, water dispersible granules and other solid preparations prepared from the crystal form B are good in stability and good in pesticide effect and have very high practical value for industrial production, popularization and application of pyroxasulfone.

Description

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AI Technical Summary

Benefits of technology

This technology solves problems with traditional methods for producing pure forms of nitroimidazoles called SAIDS because they have different types of molecules that are difficult to separate from each other due to their unique shapes like small beads on an elongated rod made up mostly of carbon atoms. These special structures can cause difficulties when trying to make certain drugs such as SALTIN® which contains this drug substance.

Problems solved by technology

Technological Problem: The technical problem addressed in this patented patent relates to finding new ways to produce metzuzanide that can be applied safely without causing harmful side effects when consumers use these compounds due to their ability to kill germ cells effectively while also being able to prevent resistance diseases like leukemia and breast cancer development. Additionally, the discovery of novel materials called metacarboxes plays important roles in developing pharmaceutical compositions containing metozozanidium salt derivatives.

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