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Binding agents and uses thereof

A technology of association and inhibitor, applied in the field of binding agent and its application

Pending Publication Date: 2022-04-26
JANSSEN PHARMA NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are currently no therapeutics on the market that directly target sadermin D for the treatment of sepsis or other inflammatory diseases

Method used

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  • Binding agents and uses thereof
  • Binding agents and uses thereof
  • Binding agents and uses thereof

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Embodiment approach

[0620] CLAIMS 1. An antidermatin D inhibitor that binds to and inhibits antidermatin D, such as wherein the inhibitor binds to and neutralizes antidermatin D.

[0621] 2. The antidermatin D inhibitor according to embodiment 1, wherein the inhibition of antidermatin D is the inhibition of:

[0622] i) the activity of nodermin D, such as wherein the inhibitor neutralizes the activity of nodermin D; and / or

[0623] ii) A function of nodermatin D, such as wherein the inhibitor neutralizes noderrmin D.

[0624] 3. An antidermatin D inhibitor that binds to and neutralizes antidermatin D.

[0625] 4. The antidermatin D inhibitor according to embodiment 3, wherein the neutralization of antidermatin D is neutralization as follows:

[0626] i) activity of nodermatin D; and / or

[0627] ii) Function of nodermatin D.

[0628] 5. The inhibitor according to any one of embodiments 1 to 4, wherein the inhibitor is an extracellular inhibitor.

[0629] 6. The inhibitor according to any one ...

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Abstract

The present invention relates to inhibitors that bind to peptin D and inhibit peptin D-mediated cell death and inflammation. The inhibitors may be proteinaceous, e.g., antigen binding proteins, or non-proteinaceous, e.g., aptamers. The present invention discloses an antibody that binds to a peptide of SEQ ID NO: 9: KREGSGRFSLPGATC. In one embodiment, the inhibitor binds to maceltin D and inhibits association of maceltin D with lipids, such as wherein the inhibitor binds to maceltin D and neutralizes association of maceltin D with lipids, optionally wherein the inhibitor binds to maceltin D and inhibits association of maceltin D with phosphatidylinositol 4-phosphate and / or phosphatidylinositol 4, 4 '-diphosphonic acid and / or phosphatidylinositol 4, 4'-diphosphonic acid and / or phosphatidylinositol 4, 4 '-diphosphonic acid and / or phosphatidylinositol 4, 4'-diphosphonic acid. The present invention relates to the association of phosphatidylinositol 4-phosphate and / or phosphatidylinositol 4, 5-diphosphate, such as wherein the inhibitor binds to maceltin D and neutralizes the association of maceltin D with phosphatidylinositol 4-phosphate and / or phosphatidylinositol 4, 5-diphosphate.

Description

technical field [0001] The disclosure provided herein relates to inhibitors that bind to gasdermin D and inhibit gasdermin D-mediated cell death and inflammation. Background technique [0002] Pyroptosis is a highly inflammatory type of programmed cell death that is induced by a variety of different threats, including microbial pathogens or host-derived perturbations of the cytosol. Pyroptosis is morphologically and mechanistically distinct from other forms of cell death and is dependent on the activation and recruitment of the protein nodermatin D to form multimeric pores in the cell membrane. The formation of these polymeric pores disrupts the cell's membrane potential, dissipating the cellular ionic gradient and causing a net increase in osmotic pressure, water influx, cell swelling and eventually osmotic lysis. The antidermatin D pores are capable of releasing inflammatory cytokines such as interleukin (IL)-1α, IL-1β, and IL-18, and cell death induced by osmotic lysis i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/18A61K39/395A61P35/00A61P31/00A61P1/16A61P37/02A61P25/28A61P25/16A61P27/02A61P9/10A61P11/00A61P11/06A61P19/06A61P1/00A61P9/12A61P13/12A61P25/00A61P29/00A61P37/06A61P3/10A61P19/02
CPCC07K16/18A61P35/00A61P31/00A61P1/16A61P37/02A61P25/28A61P25/16A61P27/02A61P9/10A61P11/00A61P11/06A61P19/06A61P1/00A61P9/12A61P13/12A61P25/00A61P29/00A61P37/06A61P3/10A61P19/02C07K2317/34C07K2317/76A61K2039/505
Inventor M·拉姆坎菲F·F·J·范哈威梅倫
Owner JANSSEN PHARMA NV
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