Biomarker for diagnosing pneumoconiosis and application thereof
A biomarker and pneumoconiosis technology, applied in the field of biomarkers for the diagnosis of pneumoconiosis, can solve the problems of pneumoconiosis, poor environment, unfavorable treatment, etc.
Active Publication Date: 2022-04-29
中元伯瑞生物科技(珠海横琴)有限公司
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Problems solved by technology
But generally speaking, if there is no respiratory protection and the environment is not good, you can suffer from pneumoconiosis in a short period of time
Due to the particularity of the pathology of pneumoconiosis and the uncertainty of its onset, the expensive and timely detection methods that are being used are increasingly unsuitable for the detection and diagnosis of pneumoconiosis. When many patients are diagnosed with pneumoconiosis, they are already in the middle and late stages. Conducive to follow-up treatment, causing patients to sink into long-term pain and suffering
Method used
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Embodiment 1
[0038] Sample collection: Select the serum of people living or working in a normal environment without pneumoconiosis, people living or working in an environment susceptible to pneumoconiosis without pneumoconiosis, and patients with pneumoconiosis who have been clinically evaluated for testing.
[0039] There are 196 samples in the model building sample group, the age range is over 30 years old, of which:
[0040] 50 people in the control group (CK) without pneumoconiosis living or working in normal environment and 85 people in the control group (CFD) living or working in the environment susceptible to pneumoconiosis without suffering from pneumoconiosis, the lung function index in these two groups Normal, chest X-ray imaging examination showed no abnormalities.
[0041] Pneumoconiosis patients (CFB), 61 people: their lung function indicators were abnormal, and chest X-ray imaging showed abnormalities.
[0042] Serum samples collected from the above population were thawed on...
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The invention provides a biomarker for diagnosing pneumoconiosis and application of the biomarker, the biomarker is application of 2-chloropalmitic acid in preparation of a detection reagent for diagnosing pneumoconiosis, the risk of suffering from pneumoconiosis is judged through the biomarker 2-chloropalmitic acid combined diglyceride (18: 1 (9Z) / 18: 3 (9Z, 12Z, 15Z)) and 2-hydroxy-6-oxocyclohexane-1-carbonyl-coenzyme A, and the risk of suffering from pneumoconiosis is judged through the biomarker 2-chloropalmitic acid combined diglyceride (18: 1 (9Z) / 18: 3 (9Z, 12Z, 15Z). And the pneumoconiosis can be prevented or prevented in advance.
Description
technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a biomarker for diagnosing pneumoconiosis and its application. Background technique [0002] Pneumoconiosis, scientifically called Pneumoconiosis, is a typical and serious occupational disease. Due to occupational reasons, workers inhale productive dust (dust) for a long time, which can easily lead to dust retention in the lungs and diffuse fibrosis of the lung tissue. serious. At present, the diagnosis of pneumoconiosis can only be confirmed by lung CT or tissue biopsy. The onset time of pneumoconiosis is affected by personal physique and protective measures. The short period may be several months, and the long period may range from several years to more than ten years. But generally speaking, if there is no respiratory protection and the environment is not good, you can suffer from pneumoconiosis in a short period of time. Due to the particularity o...
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IPC IPC(8): G01N33/92G01N33/50G01N30/02G01N30/06G01N30/86G01N30/72G16B40/10G16B40/20G16H50/30G06K9/62
CPCG01N33/92G01N33/50G01N30/02G01N30/06G01N30/72G01N30/8679G16B40/10G16B40/20G16H50/30G01N2800/122G01N2800/50G01N2405/00G01N2030/062G06F18/214G06F18/24323G06F18/2415
Inventor 陈显扬薛腾丁春光彭方达常婷婷宋王婷
Owner 中元伯瑞生物科技(珠海横琴)有限公司