Techniques for checking effectiveness of mass axis calibration of mass spectrometer of analyzer system
A technology of mass axis and mass spectrometer, applied in the field of validity of mass axis calibration, which can solve problems such as limiting calibration procedures
Pending Publication Date: 2022-05-24
F HOFFMANN LA ROCHE & CO AG
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For these reasons it is desirable to limit the frequency of such mass axis calibration procedures
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[0032] First, combine figure 1 An overview of the techniques of the present disclosure is given. Further aspects of the mass axis inspection techniques of the present disclosure will be described later in figure 2 The description is made in the context of FIG. 8 . Finally, combine Figure 9 Aspects of the analyzer system of the present disclosure are discussed.
[0033] figure 1 is a flowchart illustrating the mass axis inspection technique of the present disclosure.
[0034] A method for checking the validity of a mass axis calibration of a mass spectrometer of an analyzer system includes obtaining 101 a mass axis check sample spanning a predetermined m / z measurement range of the mass spectrometer; and automatically processing 105 the mass axis check sample. This automated processing step includes a set of sub-steps.
[0035] In particular, the technique includes using the MS to perform 107 multiple full scan mode MS measurements of different types on at least two mass...
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In one aspect, the present disclosure relates to a method for checking the effectiveness of mass axis calibration of a mass spectrometer (MS) of an analyzer system, the method comprising: obtaining a mass axis check sample across a predetermined m / z measurement range of the mass spectrometer; and automatically processing the mass axis inspection sample, including: performing, using the MS, a plurality of different types of full scan mode MS measurements on at least two mass axis points within the predetermined m / z measurement range of the MS to obtain measurement data, wherein the different types include at least a first full-scan MS measurement in a positive mode and a second measurement in a negative mode or at least a first full-scan measurement of a first mass filter of the mass spectrometer and a second full-scan mode of a second mass filter of the mass spectrometer; wherein a plurality of different full scan MS measurements are selected such that a maximum measurement time in the mass spectrometer is less than 5 minutes; comparing the measurement data of each mass axis point of the at least two mass axis points with corresponding reference data; and determining whether the mass axis calibration condition exceeds the specification based on a result of the comparing step.
Description
technical field [0001] The present disclosure relates to methods and apparatus for mass spectrometry. In particular, the present disclosure relates to methods and systems for checking the effectiveness of mass axis calibration of a mass spectrometer. Background technique [0002] In clinical laboratories and other laboratory settings, the implementation of mass spectrometry, and more specifically liquid chromatography-mass spectrometry, has received increasing attention. In these environments, it is often necessary to process a variety of different assays in a highly automated fashion and, if possible, to use random access modes (i.e. systems with large numbers of samples requiring batch-specific assays or over extended periods of time) The analyzer can perform any one of multiple assays at any time, compared to systems that process only one or two assays). Therefore, a mass spectrometer may have to provide a relatively wide m / z measurement range at any given time in order...
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IPC IPC(8): H01J49/00
CPCH01J49/0009
Inventor S·昆特F·施温伯格
Owner F HOFFMANN LA ROCHE & CO AG